A nucleated assembly mechanism of Alzheimer paired helical filaments

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

1993 • 1,951 citations

Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

1997 • 1,599 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

1996 • 974 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Prion Protein Biology

1998 • 913 citations

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

1977 • 878 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Tau protein function in living cells.

1986 • 727 citations

The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain

1988 • 671 citations

Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.

1994 • 544 citations

RNA stimulates aggregation of microtubule‐associated protein tau into Alzheimer‐like paired helical filaments

1996 • 502 citations

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

1992 • 468 citations

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro.

1992 • 463 citations

Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease βA4 peptides

1992 • 406 citations

Polymerization of τ into Filaments in the Presence of Heparin: The Minimal Sequence Required for τ ‐ τ Interaction

1996 • 387 citations

Rapid Assembly of Alzheimer-like Paired Helical Filaments from Microtubule-Associated Protein Tau Monitored by Fluorescence in Solution

1998 • 380 citations

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament.

1993 • 374 citations

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.

1995 • 347 citations

Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease.

1997 • 343 citations

The Pathogenesis of Alzheimer Disease: An Alternative to the Amyloid Hypothesis

1996 • 288 citations

Kinetics of the cooperative association of actin to actin filament

1975 • 244 citations

Patterns of aberrant sprouting in alzheimer's disease

1991 • 241 citations

Alzheimer-like Changes in Microtubule-associated Protein Tau Induced by Sulfated Glycosaminoglycans

1997 • 199 citations

Structural Neurology: Are Seeds at the Root of Neuronal Degeneration?

1997 • 172 citations

Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques

1997 • 165 citations

Assembly of Alzheimer‐like filaments from full‐length tau protein

1994 • 154 citations

Conformation and Fibrillogenesis of Alzheimer Aβ Peptides with Selected Substitution of Charged Residues

1994 • 152 citations

Polycation-induced assembly of purified tubulin.

1976 • 128 citations

Hierarchical Phosphorylation of Recombinant Tau by the Paired‐Helical Filament‐Associated Protein Kinase Is Dependent on Cyclic AMP‐Dependent Protein Kinase

1999 • 71 citations

A protein kinase associated with paired helical filaments in Alzheimer disease.

1992 • 65 citations

Tau protein and paired helical filaments of Alzheimer's disease

1993 • 33 citations

Tubulin Immunopositive Structures Resembling Intracellular Neurofibrillary Tangles

1998 • 9 citations