DNA Polymerase II, the Epsilon Polymerase of Saccharomyces cerevisiae

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

1988 • 2,903 citations

A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

1984 • 2,401 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

Proliferating cell nuclear antigen is required for DNA excision repair

1992 • 809 citations

GENETIC CONTROL OF THE CELL DIVISION CYCLE IN YEAST: V. GENETIC ANALYSIS OF cdc MUTANTS

1973 • 728 citations

A conserved 3′→5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases

1989 • 433 citations

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

1990 • 408 citations

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.

1988 • 405 citations

Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae

1988 • 361 citations

A third essential DNA polymerase in S. cerevisiae

1990 • 360 citations

Heteroduplex repair in extracts of human HeLa cells

1991 • 355 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Compilation and alignment of DNA polymerase sequences

1991 • 339 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

Complete enzymatic synthesis of DNA containing the SV40 origin of replication.

1988 • 297 citations

Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replication

1989 • 286 citations

Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.

1991 • 277 citations

REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase

1989 • 270 citations

The in vitro replication of DNA containing the SV40 origin.

1990 • 268 citations

Saccharomyces cerevisiae replication factor C. II. Formation and activity of complexes with the proliferating cell nuclear antigen and with DNA polymerases delta and epsilon.

1991 • 265 citations

Pathway correcting DNA replication errors in Saccharomyces cerevisiae.

1993 • 262 citations

Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells.

1990 • 253 citations

DNA repair synthesis in human fibroblasts requires DNA polymerase delta.

1988 • 245 citations

Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations.

1988 • 232 citations

Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III.

1989 • 231 citations

The 3′ to 5′ exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication.

1991 • 230 citations

Role of DNA polymerase alpha and DNA primase in simian virus 40 DNA replication in vitro.

1986 • 221 citations

Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation.

1991 • 211 citations

Cloning and Sequencing of the Nuclear Gene MIP1 Encoding the Catalytic Subunit of the Yeast Mitochondrial DNA Polymerase

1989 • 210 citations

Identification of replication factor C from Saccharomyces cerevisiae: a component of the leading-strand DNA replication complex.

1992 • 209 citations

Synthesis of DNA by DNA polymerase epsilon in vitro.

1991 • 204 citations

Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair.

1988 • 203 citations

Human DNA polymerase α: predicted functional domains and relationships with viral DNA polymerases

1989 • 201 citations

An essential Saccharomyces cerevisiae single-stranded DNA binding protein is homologous to the large subunit of human RP-A.

1990 • 197 citations

Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB

1989 • 193 citations

Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.

1988 • 190 citations

DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation, and protein homology with other DNA polymerases.

1988 • 168 citations

Heteroduplex DNA correction in Saccharomyces cerevisiae is mismatch specific and requires functional PMS genes.

1989 • 164 citations

DNA polymerase α

1989 • 161 citations

DNA polymerases alpha, delta, and epsilon: three distinct enzymes from HeLa cells.

1990 • 160 citations

DNA polymerase III, a second essential DNA polymerase, is encoded by the S. cerevisiae CDC2 gene

1989 • 154 citations

DNA polymerase II, the probable homolog of mammalian DNA polymerase epsilon, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae.

1992 • 154 citations

The location, sequence, transcription, and regulation of a baculovirus DNA polymerase gene

1988 • 152 citations

DNA polymerases from bakers' yeast.

1977 • 152 citations

Synthesis of DNA containing the simian virus 40 origin of replication by the combined action of DNA polymerases alpha and delta.

1989 • 148 citations

Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme.

1990 • 148 citations

Characterization of a large form of DNA polymerase δ from HeLa cells that is insensitive to proliferating cell nuclear antigen

1989 • 141 citations

Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus

1991 • 140 citations

Discontinuous DNA synthesis by purified mammalian proteins.

1990 • 135 citations

Primary structure of T4 DNA polymerase. Evolutionary relatedness to eucaryotic and other procaryotic DNA polymerases.

1988 • 134 citations

A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance

1992 • 133 citations

Exonucleolytic proofreading

1988 • 133 citations

The yeast DNA polymerase I transcript is regulated in both the mitotic cell cycle and in meiosis and is also induced after DNA damage

1987 • 129 citations

Saccharomyces cerevisiae replication factor C. I. Purification and characterization of its ATPase activity.

1991 • 128 citations

Revised nomenclature for eukaryotic DNA polymerases

1990 • 120 citations

Cell cycle control of DNA synthesis in budding yeast

1992 • 118 citations

Properties of DNA polymerases δ and ϵ, and their roles in eukaryotic DNA replication

1991 • 116 citations

DNA polymerase III from Saccharomyces cerevisiae. I. Purification and characterization.

1988 • 116 citations

A cryptic proofreading 3'----5' exonuclease associated with the polymerase subunit of the DNA polymerase-primase from Drosophila melanogaster.

1987 • 109 citations

Studies on Deoxyribonucleic Acid Polymerases from Yeast

1970 • 106 citations

CloningDPB3, the gene encoding the third subunit of DNA polymerase II ofSaccharomyces cerevisiae

1991 • 105 citations

DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae.

1991 • 105 citations

The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair

1991 • 101 citations

The highly conserved amino acid sequence motif Tyr-Gly-Asp-Thr-Asp-Ser in alpha-like DNA polymerases is required by phage phi 29 DNA polymerase for protein-primed initiation and polymerization.

1990 • 92 citations

Site-directed mutagenesis at the Exo III motif of phi 29 DNA polymerase; overlapping structural domains for the 3′-5′ exonuclease and strand-displacement activities.

1992 • 91 citations

How many pols does it take to replicate nuclear DNA?

1991 • 90 citations

Requirement for two DNA polymerases in the replication of simian virus 40 DNA in vitro.

1989 • 84 citations

The location, sequence, transcription, and regulation of a baculovirus DNA polymerase gene

1988 • 84 citations

Eukaryotic DNA Replication

1992 • 79 citations

Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase δ

1992 • 78 citations

Fidelity of DNA polymerase I and the DNA polymerase I-DNA primase complex from Saccharomyces cerevisiae.

1989 • 77 citations

Molecular cloning and primary structure of the uracil-DNA-glycosylase gene from Saccharomyces cerevisiae

1989 • 77 citations

Deoxyribonucleic Acid Polymerases from Yeast

1974 • 76 citations

DNA polymerase I is required for premeiotic DNA replication and sporulation but not for X-ray repair in Saccharomyces cerevisiae.

1989 • 74 citations

Catalytic subunit of human DNA polymerase alpha overproduced from baculovirus-infected insect cells. Structural and enzymological characterization.

1991 • 71 citations

DNA polymerization in the absence of exonucleolytic proofreading: in vivo and in vitro studies.

1991 • 69 citations

Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition

1990 • 69 citations

A 5' to 3' exonuclease functionally interacts with calf DNA polymerase epsilon.

1992 • 68 citations

Calf thymus DNA polymerase δ Independent of proliferating cell nuclear antigen (PCNA)

1989 • 67 citations

Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene.

1991 • 65 citations

The base-alteration spectrum of spontaneous and ultraviolet radiation-induced forward mutations in the URA3 locus of Saccharomyces cerevisiae

1988 • 65 citations

DNA mismatch repair in Xenopus egg extracts: repair efficiency and DNA repair synthesis for all single base-pair mismatches.

1990 • 65 citations

Structure and expression during development ofDrosophila melanogastergene for DNA polymerase α

1991 • 63 citations

Homology between mammalian DNA polymerase beta and terminal deoxynucleotidyltransferase.

1987 • 60 citations

T5 DNA polymerase: structural--functional relationships to other DNA polymerases.

1989 • 58 citations

Site-specific mutagenesis of a highly conserved region of the herpes simplex virus type 1 DNA polymerase gene

1990 • 49 citations

Yeast mitochondrial DNA polymerase is related to the family A DNA polymerases

1990 • 48 citations

Purification and characterization of the 180- and 86-kilodalton subunits of the Saccharomyces cerevisiae DNA primase-DNA polymerase protein complex. The 180-kilodalton subunit has both DNA polymerase and 3‘—-5‘-exonuclease activities.

1991 • 46 citations

Escherichia coli DNA polymerase II is homologous to α-like DNA polymerases

1991 • 45 citations

Nucleotide sequence and characterization of temperature-sensitive pol1 mutants of Saccharomyces cerevisiae

1990 • 44 citations

Identification and tryptic cleavage of the catalytic core of HeLa and calf thymus DNA polymerase epsilon.

1991 • 43 citations

Purification of DNA Polymerase II, a Distinct DNA Polymerase, from Saccharomyces cerevisiae

1989 • 42 citations

Aphidicolin resistance in Herpes simplex virus type I reveals features of the DNA polymerase dNTP binding site

1989 • 42 citations

DNA polymerases delta and epsilon are required for chromosomal replication in Saccharomyces cerevisiae.

1993 • 39 citations

DNA polymerase III from Saccharomyces cerevisiae. II. Inhibitor studies and comparison with DNA polymerases I and II.

1988 • 38 citations

The Presence of an Exonuclease in Highly Purified DNA Polymerase from Bakers' Yeast

1973 • 37 citations

Mutagenesis of conserved region I in the DNA polymerase from human adenovirus serotype 2

1991 • 33 citations

Yeast DNA Polymerases: Antigenic Relationship, Use of RNA Primer and Associated Exonuclease Activity

1978 • 32 citations

Site-directed mutagenesis of the YCDTDS amino acid motif of the Φ29 DNA polymerase

1990 • 27 citations

DNA polymerase epsilon: The latest member in the family of mammalian DNA polymerases

1990 • 25 citations

MIP1 DNA polymerase of S.cerevisiae: structural similarity with theE.coliDNA polymerase I-type enzymes

1991 • 22 citations

Possible involvement of the yeast POLIII DNA polymerase in induced gene conversion

1991 • 22 citations

Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site.

1991 • 17 citations

Purification of DNA polymerase II stimulatory factor I, a yeast single-stranded DNA-binding protein.

1990 • 16 citations

Nucleotide sequence of thePOL3 gene encoding DNA polymerase III (δ) ofSaccharomyces cerevisiae

1992 • 14 citations

The 66 kDa component of yeast SF1, stimulatory factor I, is hsp6O

1992 • 13 citations