The highly conserved amino acid sequence motif Tyr-Gly-Asp-Thr-Asp-Ser in alpha-like DNA polymerases is required by phage phi 29 DNA polymerase for protein-primed initiation and polymerization.

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

Highly Efficient DNA Synthesis by the Phage ϕ 29 DNA Polymerase

1989 • 671 citations

Structure of concanavalin A at 2.4-Ang resolution

1972 • 477 citations

A conserved 3′→5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases

1989 • 433 citations

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.

1988 • 405 citations

A sequence motif in many polymerases

1988 • 405 citations

Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.

1985 • 396 citations

New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase α

1981 • 389 citations

Sequence and structure of yeast phosphoglycerate kinase.

1982 • 364 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

A novel superfamily of nucleoside triphosphate‐binding motif containing proteins which are probably involved in duplex unwinding in DNA and RNA replication and recombination

1988 • 282 citations

A Model for the Tertiary Structure of p21, the Product of the ras Oncogene

1985 • 248 citations

Related functional domains in virus DNA polymerases.

1987 • 243 citations

A versatile primer for DNA sequencing in the M13mp2 cloning system

1980 • 241 citations

Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III.

1989 • 231 citations

Homology between DNA polymerases of poxviruses, herpesviruses, and adenoviruses: nucleotide sequence of the vaccinia virus DNA polymerase gene.

1986 • 191 citations

Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

1985 • 172 citations

Sequence and transcription analysis of the human cytomegalovirus DNA polymerase gene

1987 • 170 citations

DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation, and protein homology with other DNA polymerases.

1988 • 168 citations

Initiation of phage phi 29 DNA replication in vitro: formation of a covalent complex between the terminal protein, p3, and 5'-dAMP.

1982 • 166 citations

Structural and functional relationships between prokaryotic and eukaryotic DNA polymerases.

1987 • 157 citations

The location, sequence, transcription, and regulation of a baculovirus DNA polymerase gene

1988 • 152 citations

Characterization and purification of a phage phi 29-encoded DNA polymerase required for the initiation of replication.

1984 • 148 citations

Analysis of sequence-similar pentapeptides in unrelated protein tertiary structures

1987 • 118 citations

Replication of phage phi 29 DNA with purified terminal protein and DNA polymerase: synthesis of full-length phi 29 DNA.

1985 • 100 citations

Butylphenyl dGTP: a selective and potent inhibitor of mammalian DNA polymerase alpha

1984 • 94 citations

Location of the serine residue involved in the linkage between the terminal protein and the DNA of phage φ29

1985 • 90 citations

Overproduction and purification of protein P6 ofBacillus subtilisphage φ29: role in the initiation of DNA replication

1985 • 82 citations

Interference with viral infection by defective RNA replicase

1987 • 79 citations

Characterization of a 3′ → 5′ exonuclease activity in the phage φ29-encoded DNA polymerase

1985 • 72 citations

Replication of bacteriophage phi 29 DNA in vitro: the roles of terminal protein and DNA polymerase.

1984 • 61 citations

Identification by a random sequencing strategy of the fowlpoxvirus DNA polymerase gene, its nucleotide sequence and comparison with other viral DNA polymerases

1987 • 56 citations

Effect of NH4+ ions on phi 29 DNA-protein p3 replication: formation of a complex between the terminal protein and the DNA polymerase

1987 • 54 citations

In organello replication and viral affinity of linear, extrachromosomal DNA of the ascomycete Ascobolus immersus

1989 • 51 citations

Purification in a functional form of the terminal protein of Bacillus subtilis phage phi 29.

1984 • 42 citations

Elucidation of the mechanism of selective inhibition of mammalian DNA polymerase alpha by 2-butylanilinopurines: development and characterization of 2-(p-n-butylanilino) adenine and its deoxyribonucleotides

1985 • 41 citations

Effect of aphidicolin and nucleotide analogs on the phage θ29 DNA polymerase

1986 • 36 citations

Bacteriophage ϕ29 DNA replication in vitro: Participation of the terminal protein and the gene 2 product in elongation

1984 • 25 citations

Transcription in Vitro of φ 29 DNA and EcoRI Fragments by Bacillus subtilis RNA Polymerase

1976 • 18 citations