Role of nitric oxide in cellular iron metabolism.

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

1992 • 1,454 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

1996 • 1,311 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

1997 • 1,178 citations

Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport

1998 • 946 citations

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

1988 • 707 citations

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

1997 • 697 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Function and regulation of transferrin and ferritin.

1998 • 518 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

2001 • 479 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Nramp2 is mutated in the anemic Belgrade (b) rat : evidence of a role for Nramp2 in endosomal iron transport

1998 • 410 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.

1991 • 349 citations

Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein.

1992 • 345 citations

Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

1989 • 332 citations

Rapid responses to oxidative stress mediated by iron regulatory protein.

1995 • 331 citations

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins

1998 • 297 citations

Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster.

1992 • 272 citations

Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity.

1994 • 262 citations

Ferritin Synthesis in Inflammation: I. PATHOGENESIS OF IMPAIRED IRON RELEASE

1977 • 254 citations

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.

1995 • 226 citations

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.

1995 • 209 citations

Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−

1999 • 208 citations

A regulated RNA binding protein also possesses aconitase activity.

1991 • 204 citations

Polynitrosylated proteins: characterization, bioactivity, and functional consequences.

1996 • 194 citations

Nitric Oxide and Oxidative Stress (H₂O₂) Control Mammalian Iron Metabolism by Different Pathways

1996 • 194 citations

Iron Catalyzes both Decomposition and Synthesis ofS-Nitrosothiols: Optical and Electron Paramagnetic Resonance Studies

1997 • 185 citations

Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages

1984 • 183 citations

Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.

1997 • 181 citations

Mutational analysis of the [4Fe-4S]-cluster converting iron regulatory factor from its RNA-binding form to cytoplasmic aconitase.

1994 • 176 citations

Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.

1993 • 169 citations

Differences in the Regulation of Iron Regulatory Protein-1 (IRP-1) by Extra- and Intracellular Oxidative Stress

1997 • 164 citations

Physiology and pathophysiology of nitric oxide.

1996 • 141 citations

Identification of a Conserved and Functional Iron-responsive Element in the 5′-Untranslated Region of Mammalian Mitochondrial Aconitase

1996 • 141 citations

Effects of Interferon-γ and Lipopolysaccharide on Macrophage Iron Metabolism Are Mediated by Nitric Oxide-induced Degradation of Iron Regulatory Protein 2

2000 • 141 citations

Nitric Oxide–Mediated Induction of Ferritin Synthesis in J774 Macrophages by Inflammatory Cytokines: Role of Selective Iron Regulatory Protein-2 Downregulation

1998 • 137 citations

Characterization and Expression of Iron Regulatory Protein 2 (IRP2)

1995 • 127 citations

Activation of iron regulatory protein-1 by oxidative stress in vitro

1998 • 126 citations

A model for the structure and functions of iron-responsive elements

1988 • 119 citations

Modulation of Cellular Iron Metabolism by Hydrogen Peroxide

2001 • 116 citations

Modification of a free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding.

1993 • 103 citations

The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells

1995 • 99 citations

Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes.

1987 • 95 citations

Control of Transferrin Receptor Expression via Nitric Oxide-mediated Modulation of Iron-regulatory Protein 2

1999 • 93 citations

Nanomolar Quantification and Identification of Various Nitrosothiols by High Performance Liquid Chromatography Coupled with Flow Reactors of Metals and Griess Reagent

1997 • 81 citations

Nitrogen monoxide-mediated control of ferritin synthesis: Implications for macrophage iron homeostasis

2002 • 74 citations

Factors affecting the pathway of glutamate oxidation in rat-liver mitochondria

1967 • 70 citations

Converse Modulation of IRP1 and IRP2 by Immunological Stimuli in Murine RAW 264.7 Macrophages

1998 • 70 citations

Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line

1997 • 62 citations

Analysis of Neuronal NO Synthase under Single-Turnover Conditions: Conversion ofN^ω-Hydroxyarginine to Nitric Oxide and Citrulline

1997 • 60 citations

Expression of the transferrin receptor on murine peritoneal macrophages is modulated by in vitro treatment with interferon gamma

1984 • 58 citations

Iron regulatory proteins 1 and 2

1996 • 56 citations

Inhibition Involves the Iron-Sulfur Prosthetic Group and Is Reversible

1986 • 49 citations

Expression and Βiochemical Characterization of Iron Regulatory Proteins 1 and 2 in Saccharomyces cerevisiae

1996 • 45 citations

Differential Sensitivity of the Tyrosyl Radical of Mouse Ribonucleotide Reductase to Nitric Oxide and Peroxynitrite

1998 • 41 citations

Effects of Nitrogen Monoxide on Cellular Iron Metabolism

1996 • 25 citations