Arachidonic Acid and Other Fatty Acids Directly Activate Potassium Channels in Smooth Muscle Cells

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Single-Channel Recording

1995 • 2,565 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function

1984 • 1,616 citations

Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons

1989 • 1,456 citations

Current Topics in Membranes and Transport

1970 • 1,240 citations

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain

1970 • 854 citations

Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

1987 • 640 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium.

1981 • 607 citations

The concept of lipid domains in membranes.

1982 • 466 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets.

1986 • 310 citations

Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel

1989 • 299 citations

Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.

1981 • 295 citations

Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin.

1984 • 230 citations

Volatile general anaesthetics activate a novel neuronal K+ current

1988 • 199 citations

Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism

1988 • 194 citations

How bilayer lipids affect membrane protein activity

1986 • 186 citations

Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes.

1985 • 177 citations

Enzymology and Physiology of Reticulocyte Lipoxygenase: Comparison with Other Lipoxygenases

1986 • 170 citations

Fatty acid metabolism of isolated mammalian cells

1987 • 158 citations

Specificity in the enzymic conversion of polyunsaturated fatty acids into prostaglandins

1966 • 137 citations

Stimulation of guanylate cyclase of fibroblasts by free fatty acids.

1976 • 134 citations

The effect of 5,8,11,14‐eicosatetraynoic acid on lipid metabolism

1979 • 134 citations

Calcium-Independent Activation of Hypothalamic Type I Protein Kinase C by Unsaturated Fatty Acids

1988 • 120 citations

Membrane fluidity: structure and dynamics of membrane lipids.

1983 • 110 citations

Cholinergic agonists suppress a potassium current in freshly dissociated smooth muscle cells of the toad.

1985 • 102 citations

Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol

1988 • 90 citations

Arachidonic acid closes gap junction channels in rat lacrimal glands

1989 • 80 citations

Activation of soluble guanylate cyclase by arachidonic acid and 15-lipoxygenase products

1986 • 77 citations

Purification of soluble guanylate cyclase from rat liver

1979 • 75 citations

Prostaglandin H synthase: Distinct binding sites for cyclooxygenase and peroxidase substrates

1988 • 74 citations

Antagonistic Adrenergic-Muscarinic Regulation of M Current in Smooth Muscle Cells

1988 • 69 citations

The lipid structure of biological membranes

1985 • 65 citations

Hormone-sensitive lipase of adipose tissue.

1977 • 52 citations

Characterization of a delayed rectifier K+ channel in NG108-15 neuroblastomaX glioma cells: Gating kinetics and the effects of enrichment of membrane phospholipids with arachidonic acid

1988 • 39 citations

Oxygenation of trans polyunsaturated fatty acids by lipoxygenase reveals steric features of the catalytic mechanism

1987 • 37 citations

Effect of saturated and unsaturated fatty acids on the oxidative metabolism of human neutrophils. The role of calcium ion in the extracellular medium

1986 • 33 citations

Effects of fatty acids on membrane currents in the squid giant axon

1987 • 32 citations

Effects of Anesthetics on the Squid Giant Axon

1984 • 32 citations

Effects of arachidonic acid and the other long-chain fatty acids on the membrane currents in the squid giant axon

1988 • 27 citations

Activation of purified soluble guanylate cyclase by arachidonic acid requires absence of enzyme-bound heme

1987 • 25 citations

Modulation of Rabbit Neutrophil Aggregation and Degranulation by Free Fatty Acids

1984 • 18 citations

Indomethacin, prostaglandin E2 and transmission at the frog neuromuscular junction.

1985 • 16 citations

Characterization of prostaglandin endoperoxide synthase from a human cell line

1986 • 6 citations