Distinct antigen MHC class II complexes generated by separate processing pathways.

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Protein folding in the cell

1992 • 4,138 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

The folding of hen lysozyme involves partially structured intermediates and multiple pathways

1992 • 719 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

1982 • 576 citations

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1995 • 555 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

Structure of Peptides Associated with Class I and Class II MHC Molecules

1994 • 381 citations

An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

1994 • 378 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Article

1995 • 325 citations

How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the Endocytic Pathway

1995 • 280 citations

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.

1984 • 272 citations

Antigen presentation mediated by recycling of surface HLA-DR molecules

1995 • 271 citations

HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 247 citations

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells

1994 • 247 citations

A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family.

1989 • 246 citations

Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments

1994 • 244 citations

[11] Radioiodination of proteins by the use of the chloramine-T method

1980 • 225 citations

ATP is required for receptor-mediated endocytosis in intact cells.

1990 • 206 citations

Clonal analysis of B- and T-cell responses to Ia antigens

1981 • 205 citations

Processed antigen binds to newly synthesized mhc class II molecules in antigen-specific B lymphocytes

1991 • 188 citations

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

1994 • 175 citations

Processing of lysozyme by macrophages: identification of the determinant recognized by two T-cell hybridomas.

1984 • 175 citations

Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak.

1992 • 174 citations

Autologous Peptides Constitutively Occupy the Antigen Binding Site on Ia

1988 • 157 citations

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.

1995 • 150 citations

Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum.

1996 • 146 citations

Effects of pH and polysaccharides on peptide binding to class II major histocompatibility complex molecules.

1991 • 144 citations

MHC class II function preserved by low-affinity peptide interactions preceding stable binding

1994 • 135 citations

Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells

1994 • 135 citations

Capacity of intact proteins to bind to MHC class II molecules.

1989 • 129 citations

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.

1992 • 125 citations

HLA-DM Is Localized to Conventional and Unconventional MHC Class II–Containing Endocytic Compartments

1996 • 122 citations

Role of B cell receptor Igα and Igβ subunits in MHC class II-restricted antigen presentation

1995 • 115 citations

Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen.

1994 • 113 citations

Identification of two distinct properties of class II major histocompatibility complex-associated peptides.

1993 • 101 citations

T cell recognition of fibrinogen. A determinant on the A alpha-chain does not require processing.

1988 • 100 citations

Antigen presentation abrogated in cells expressing truncated Ia molecules.

1989 • 81 citations

Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes.

1994 • 78 citations

Antigen presentation of hen egg‐white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II‐associated invariant chain

1991 • 74 citations

HLA-DM: An in vivo facilitator of MHC class II peptide loading

1995 • 74 citations

Studies of two antigenic forms of Ld with disparate beta 2-microglobulin (beta 2m) associations suggest that beta 2m facilitate the folding of the alpha 1 and alpha 2 domains during de novo synthesis.

1988 • 66 citations

Phospholipids enhance the binding of peptides to class II major histocompatibility molecules.

1990 • 56 citations

Kinetics of the reactions between the invariant chain (85–99) peptide and proteins of the murine class II MHC

1995 • 55 citations

Characterization of fragments of the murine Ia-associated invariant chain.

1991 • 49 citations

New insights suggesting a possible role of a heat shock protein 70-kD family-related protein in antigen processing/presentation phenomenon in humans

1993 • 47 citations

Molecular chaperones in the processing and presentation of antigen to helper T cells

1994 • 35 citations

Characterization of naturally processed antigen bound to major histocompatibility complex class II molecules.

1991 • 29 citations

Evidence for invariant chain 85-101 (CLIP) binding in the antigen binding site of MHC class II molecules

1995 • 25 citations

The sites in the I-Ak histocompatibility molecule photoaffinity labeled by an immunogenic lysozyme peptide.

1990 • 19 citations

Purification and photoaffinity labeling of the I-Ak histocompatibility molecule

1990 • 10 citations