[48] N-acetylcysteine

The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

1989 • 1,769 citations

Oxidants and antioxidants: State of the art

1991 • 623 citations

Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients

1989 • 349 citations

Clinical Pharmacokinetics of N-Acetylcysteine

1991 • 338 citations

Pharmacokinetics of N-acetylcysteine in man

1986 • 333 citations

Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

1988 • 329 citations

Lung Protection by a Thiol-Containing Antioxidant: N-Acetylcysteine

1986 • 266 citations

Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives

1991 • 256 citations

N-Acetylcysteine in experimental and clinical acute lung injury

1991 • 237 citations

Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems

1986 • 235 citations

Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration

1989 • 234 citations

Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.

1991 • 179 citations

Metabolic activation and hepatotoxicity

1979 • 158 citations

N-Acetylcysteine: A New Approach to Anti-HIV Therapy

1992 • 157 citations

High-performance liquid chromatography and fluorometric detection of biologically important thiols, derivatized with ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate (SBD-F)

1983 • 156 citations

New fluorogenic reagent having halogenobenzofurazan structure for thiols: 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole

1984 • 153 citations

Modulation of lymphocyte functions and immune responses by cysteine and cysteine derivatives

1991 • 131 citations

Antioxidant activity and other mechanisms of thiols involved in chemoprevention of mutation and cancer

1991 • 111 citations

Prevention and Reversal of Tolerance to Nitroglycerine with N-Acetylcysteine

1985 • 111 citations

Mechanisms for the pharmacologic interaction of organic nitrates with thiols. Existence of an extracellular pathway for the reversal of nitrate vascular tolerance by N-acetylcysteine.

1988 • 108 citations

Inhibition of urethan-induced lung tumors in mice by dietary N-acetylcysteine

1986 • 104 citations

Metabolism of N-acetyl-l-cysteine Some structural requirements for the deacetylation and consequences for the oral bioavailability

1989 • 103 citations

The metabolism of N-acetylcysteine by human endothelial cells

1991 • 95 citations

N-acetylcysteine and glutathione-dependent protective effect of PZ51 (Ebselen) against diquat-induced cytotoxicity in isolated hepatocytes

1987 • 75 citations

N-Acetylcysteine Inhibits Latent HIV Expression in Chronically Infected Cells

1991 • 75 citations

Dose dependent pharmacokinetics of N‐ACETYLCYSTEINE AFTER ORAL DOSING TO MAN

1990 • 63 citations

Gastrointestinal metabolism of N‐acetylcysteine in the rat, including an assay for sulfite in biological systems

1987 • 63 citations

Anti-initiation activity of N-acetylcysteine in experimental colonic carcinogenesis

1986 • 46 citations

Reversed-phase ion-pair high-performance liquid chromatography of mercaptoacetate and N-acetylcysteine after derivatization with N-(1-pyrene)maleimide and N-(7-dimethylamino-4-methyl-3-coumarinyl)maleimide

1982 • 45 citations

Interactions between organic nitrates and thiol groups

1991 • 36 citations

Methodologies for the analysis of reduced and oxidized N‐acetylcysteine in biological systems

1987 • 35 citations

Rapid tolerance to the hypotensive effects of glyceryl trinitrate in the rat: prevention by N‐acetyl‐<scp>l</scp>‐ but not N‐acetyl‐<scp>d</scp>‐cysteine

1990 • 31 citations

Improved method for the determination of N-acetylcysteine in human plasma by high-performance liquid chromatography

1985 • 26 citations

Endogenous plasma N‐acetylcysteine and single dose oral bioavailability from two different formulations as determined by a new analytical method

1991 • 22 citations

Effects of aminothiols in 2-acetylaminofluorene-treated rats. I. Damage and repair of liver DNA, hyperplastic foci, and Zymbal gland tumors.

1987 • 21 citations

Drug Reactions and the Liver

1982 • 17 citations

Differential assay and biological significance of poly(ADP-ribose) polymerase activity in isolated liver nuclei

1990 • 13 citations

Bioavailability of suckable tablets of oral N-acetylcysteine in man

1989 • 10 citations

Inhibition of development of tolerance to nitroglycerin by preventive administration of N-acetylcysteine in rats.

1989 • 8 citations

Thiol-containing agents in the management of unstable angina pectoris and acute myocardial infarction

1991 • 7 citations