A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

1991 • 3,691 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

A family of human cdc2-related protein kinases.

1992 • 928 citations

Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe

1976 • 906 citations

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

1981 • 740 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Inactivation of the p34 ^cdc2 -Cyclin B Complex by the Human WEE1 Tyrosine Kinase

1992 • 688 citations

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2

1991 • 688 citations

Regulation of p34cdc2 protein kinase during mitosis

1989 • 544 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation

1986 • 502 citations

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle

1994 • 478 citations

Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.

1993 • 475 citations

Growth in cell length in the fission yeast Schizosaccharomyces pombe

1985 • 466 citations

Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2

1993 • 464 citations

Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication

1990 • 460 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis

1989 • 453 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.

1992 • 417 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication

1993 • 389 citations

p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.

1987 • 387 citations

Fission yeast genes involved in coupling mitosis to completion of DNA replication.

1992 • 382 citations

p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase.

1989 • 376 citations

Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene

1994 • 356 citations

Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus

1990 • 354 citations

Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.

1994 • 346 citations

Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase

1991 • 344 citations

p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast.

1991 • 342 citations

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

1991 • 340 citations

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

1991 • 318 citations

Isolation and characterization of Schizosaccharomyces pombe cut mutants that block nuclear division but not cytokinesis

1986 • 292 citations

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

1992 • 276 citations

Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeast

1990 • 266 citations

Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint.

1993 • 263 citations

cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis.

1994 • 232 citations

Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+

1993 • 231 citations

Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 ‘start’ gene.

1985 • 228 citations

Controls over the timing of DNA replication during the cell cycle of fission yeast

1977 • 204 citations

Cyclin B targets p34cdc2 for tyrosine phosphorylation.

1991 • 152 citations

Pyp3 PTPase acts as a mitotic inducer in fission yeast.

1992 • 117 citations

Feedback controls and G2 checkpoints: Fission yeast as a model system

1993 • 113 citations

Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.

1994 • 111 citations

GENETICS OF THE FISSION YEAST SCHIZOSACCHAROMYCES POMBE

1992 • 90 citations

A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans

1994 • 85 citations

Influence of the composition of commercial sodium dodecyl sulfate preparations on the separation of α- and β-tubulin during polyacrylamide gel electrophoresis

1981 • 77 citations

Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast.

1992 • 66 citations

Subcellular localization of a protein kinase required for cell cycle initiation in Saccharomyces cerevisiae: evidence for an association between the CDC28 gene product and the insoluble cytoplasmic matrix.

1987 • 63 citations

Mitotic Checkpoint Control in Fission Yeast

1991 • 55 citations

The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis.

1992 • 50 citations

Isolation, characterisation and molecular cloning of new mutant alleles of the fission yeast p34 cdc2+ protein kinase gene: identification of temperature-sensitive G2-arresting alleles

1991 • 44 citations

Mutational analysis supports a structural model for the cell cycle protein kinase p34

1994 • 42 citations

Mutations in the cdc10 start gene of Schizosaccbaromyces pombe implicate the region of homology between cdc10 and SWl6 as important for p85cdc10 function

1992 • 35 citations

Cell cycle-regulated degradation of Xenopus cyclin B2 requires binding to p34cdc2.

1994 • 31 citations

p63cdc13, a B-type cyclin, is associated with both the nucleolar and chromatin domains of the fission yeast nucleus.

1993 • 22 citations

The Fission Yeast Genes pyp1⁺ and pyp2⁺ Encode Protein Tyrosine Phosphatases That Negatively Regulate Mitosis

1992 • 17 citations

Genetic analysis of human p34CDC2 function in fission yeast

1993 • 11 citations