Cell cycle-regulated degradation of Xenopus cyclin B2 requires binding to p34cdc2.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Fluorographic detection of radioactivity in polyacrylamide gols with the water-soluble fluor, sodium salicylate

1979 • 1,976 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

1981 • 740 citations

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

1990 • 730 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Cyclin is a component of maturation-promoting factor from Xenopus

1990 • 674 citations

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

1989 • 666 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.

1993 • 483 citations

Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.

1992 • 459 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

Cyclins and cyclin-dependent kinases: take your partners

1993 • 441 citations

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1991 • 439 citations

S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase

1993 • 422 citations

Induction of nuclear envelope breakdown, chromosome condensation, and spindle formation in cell-free extracts.

1985 • 407 citations

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

1993 • 391 citations

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

1993 • 377 citations

The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

1990 • 377 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.

1993 • 326 citations

Cell Cycle Regulation in the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe

1991 • 326 citations

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

1991 • 319 citations

The Role of p34 Kinases in the G1 to S-Phase Transition

1992 • 313 citations

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis

1991 • 310 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition.

1990 • 262 citations

On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis.

1991 • 262 citations

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.

1991 • 246 citations

Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit

1993 • 244 citations

The role of cyclin B in meiosis I.

1989 • 241 citations

The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo.

1992 • 236 citations

A bifunctional gene product involved in two phases of the yeast cell cycle

1982 • 225 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.

1992 • 191 citations

G1-specific cyclins: in search of an S-phase-promoting factor

1991 • 181 citations

Cyclins and their partners: from a simple idea to complicated reality.

1991 • 159 citations

Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.

1994 • 148 citations

Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase.

1993 • 147 citations

Control of programmed cyclin destruction in a cell-free system.

1989 • 138 citations

Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.

1994 • 111 citations

Conserved structural motifs in cyclins identified by sequence analysis

1991 • 110 citations

Effects of Ca2+ ions on the formation of metaphase chromosomes and sperm pronuclei in cell-free preparations from unactivated Rana pipiens eggs

1984 • 90 citations

Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions.

1991 • 88 citations

Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25

1993 • 79 citations

cdc2 activation: the interplay of cyclin binding and Thr161 phosphorylation

1993 • 72 citations

Sequences Within the Conserved Cyclin Box of Human Cyclin A are Sufficient for Binding to and Activation of cdc2 Kinase

1993 • 50 citations

Mitotic arrest caused by the amino terminus of Xenopus cyclin B2.

1993 • 48 citations

Phosphorylation of Xenopus Cyclins B1 and B2 Is Not Required for Cell Cycle Transitions

1991 • 29 citations

Cloning and Characterization of Xenopus cdc2, a Component of MPF

1991 • 22 citations

Mitotic Arrest Caused by the Amino Terminus of Xenopus Cyclin B2

1993 • 11 citations