Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

Genetic Control of Flower Development by Homeotic Genes in Antirrhinum majus

1990 • 852 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF

1991 • 447 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction

1989 • 346 citations

Inducible binding of a factor to the c-fos enhancer

1986 • 310 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

The SRE: a growth factor responsive transcriptional regulator.

1990 • 287 citations

A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.

1993 • 253 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Distinct Protein Targets for Signals Acting at the c- fos Serum Response Element

1991 • 244 citations

A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes.

1989 • 239 citations

Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro.

1987 • 238 citations

Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter

1992 • 225 citations

Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal alpha-actin transcription in embryonic myoblasts.

1992 • 221 citations

Casein kinase II enhances the DNA binding activity of serum response factor.

1990 • 181 citations

Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer.

1988 • 180 citations

Spatial flexibility in ternary complexes between SRF and its accessory proteins.

1992 • 175 citations

Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange.

1992 • 165 citations

The yeast transcription activator PRTF, a homolog of the mammalian serum response factor, is encoded by the MCM1 gene.

1989 • 160 citations

Synergism in ternary complex formation between the dimeric glycoprotein p67SRF, polypeptide p62TCF and the c-fos serum response element.

1990 • 157 citations

A protein domain conserved between yeast MCM1 and human SRF directs ternary complex formation.

1991 • 140 citations

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

1991 • 138 citations

Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties.

1992 • 132 citations

Identification of transcriptional activation and inhibitory domains in serum response factor (SRF) by using GAL4-SRF constructs.

1993 • 120 citations

The human c-fos serum response factor and the yeast factors GRM/PRTF have related DNA-binding specificities.

1988 • 117 citations

SRF and MCM1 have related but distinct DNA binding specificities

1992 • 99 citations

Point mutational analysis of the humanc-fosserum response factor binding site

1989 • 98 citations

Ternary complex formation over the c-fos serum response element: p62TCF exhibits dual component specificity with contacts to DNA and an extended structure in the DNA-binding domain of p67SRF.

1992 • 94 citations

Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II.

1991 • 88 citations

Casein kinase II induces c-fos expression via the serum response element pathway and p67SRF phosphorylation in living fibroblasts.

1991 • 76 citations

Cell-type specific multiprotein complex formation over the c-fosserum response elementin vivo: ternary complex formation is not required for the induction of c-fos

1991 • 73 citations

A Growth Factor-Induced Kinase Phosphorylates the Serum Response factor at a Site that Regulates its DNA-Binding Activity

1993 • 71 citations

The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites.

1993 • 63 citations

Cell-specific regulation of oncogene-responsive sequences of the c-fos promoter.

1991 • 62 citations

Maximal serum stimulation of the c-fos serum response element requires both the serum response factor and a novel binding factor, SRE-binding protein.

1992 • 35 citations

Identification of a coactivator that increases activation of transcription by serum response factor and GAL4-VP16 in vitro.

1992 • 32 citations

Identification of Transcriptional Activation and Inhibitory Domains in Serum Response Factor (SRF) by Using GAL4-SRF Constructs

1993 • 31 citations

Mutation of Serum Response Factor Phosphorylation Sites and the Mechanism by which Its DNA-Binding Activity Is Increased by Casein Kinase II

1991 • 27 citations