The functional versatility of CREM is determined by its modular structure.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

1991 • 1,019 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

1991 • 655 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Developmental switch of CREM function during spermatogenesis: from antagonist to activator

1992 • 495 citations

Cell Lines of the Pituitary Gonadotrope Lineage Derived by Targeted Oncogenesis in Transgenic Mice

1990 • 493 citations

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1991 • 436 citations

Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements.

1987 • 409 citations

Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.

1989 • 396 citations

MINIREVIEW: Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors

1990 • 394 citations

Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.

1988 • 391 citations

Dimers, leucine zippers and DNA-binding domains

1990 • 377 citations

The CREB family of transcription activators

1992 • 298 citations

More is better: Activators and repressors from the same gene

1992 • 280 citations

Regulation of transcription by cyclic AMP-dependent protein kinase.

1989 • 247 citations

Transcription factors: a new family gathers at the cAMP response site

1990 • 244 citations

mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element.

1990 • 237 citations

Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.

1990 • 236 citations

Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB.

1991 • 229 citations

Characterization of a bipartite activator domain in transcription factor CREB

1990 • 228 citations

The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.

1991 • 224 citations

Both the basic region and the ‘leucine zipper’ domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.

1990 • 196 citations

Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes.

1992 • 189 citations

An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins.

1991 • 150 citations

Analysis of the cAMP-Dependent Protein Kinase System Using Molecular Genetic Approaches

1988 • 148 citations

Two functionally different regions in Fos are required for the sequence-specific DNA interaction of the Fos/Jun protein complex

1989 • 147 citations

Signal transduction and gene control: the cAMP pathway.

1992 • 142 citations

Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver.

1991 • 139 citations

The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43.

1990 • 133 citations

Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions.

1992 • 131 citations

A Dominant Negative form of Transcription Activator mTFE3 Created by Differential Splicing

1991 • 129 citations

Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A trans-activation.

1988 • 128 citations

Twin of I-POU: A two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription

1992 • 113 citations

Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression.

1991 • 108 citations

Identification of the promoter sequences involved in the cell specific expression of the rat somatostatin gene

1987 • 82 citations

Differential regulation of three members of the ATF/CREB family of DNA-binding proteins.

1991 • 82 citations

Tissue-Specific Enhancer of the Human Glycoprotein Hormone α-Subunit Gene: Dependence on Cyclic AMP-Inducible Elements

1987 • 71 citations

Analysis of dimerization and DNA binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region.

1990 • 67 citations

An α-Subunit-Secreting Cell Line Derived from a Mouse Thyrotrope Tumor

1990 • 65 citations

Characterization of Motifs Which Are Critical for Activity of the Cyclic AMP-Responsive Transcription Factor CREB

1991 • 57 citations

mXBP/CRE-BP2 and c-Jun Form a Complex Which Binds to the Cyclic AMP, but Not to the 12-O-Tetradecanoylphorbol-13-Acetate, Response Element

1990 • 56 citations

Domain Swapping Reveals the Modular Nature of Fos, Jun, and CREB Proteins

1990 • 46 citations

Transformation and transactivation suppressor activity of the c-Jun leucine zipper fused to a bacterial repressor.

1992 • 44 citations