Heat Shock Regulation

Principles that Govern the Folding of Protein Chains

1973 • 6,771 citations

Molecular basis of bacterial outer membrane permeability

1985 • 2,171 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

The crystal structure of the bacterial chaperonln GroEL at 2.8 Å

1994 • 1,322 citations

The Biology of heat shock proteins and molecular chaperones.

1994 • 1,226 citations

The biology of heat shock proteins and molecular chaperones

1994 • 1,203 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 1,096 citations

MOLECULAR CHAPERONES

1991 • 1,089 citations

Identification of a protein required for disulfide bond formation in vivo

1991 • 967 citations

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

1992 • 965 citations

Molecular basis of bacterial outer membrane permeability.

1985 • 904 citations

The sigma 70 family: sequence conservation and evolutionary relationships

1992 • 894 citations

Protein disaggregation mediated by heat-shock protein Hspl04

1994 • 861 citations

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

1991 • 835 citations

Reconstitution of active dimeric ribulose bisphosphate carboxylase from an unfolded state depends on two chaperonin proteins and Mg-ATP

1989 • 737 citations

Stress proteins in biology and medicine

1990 • 731 citations

Folding and association of proteins

1987 • 697 citations

The groES and groEL heat shock gene products of Escherichia coli are essential for bacterial growth at all temperatures

1989 • 693 citations

Is hsp70 the cellular thermometer?

1991 • 586 citations

Heat Shock Response

1991 • 576 citations

Genetics of lipopolysaccharide biosynthesis in enteric bacteria

1993 • 507 citations

Expression of sigma 54 (ntrA)-dependent genes is probably united by a common mechanism

1989 • 504 citations

Stress proteins in biology and medicine

1990 • 502 citations

Analysis of the Streptomyces coelicolor sigE gene reveals the existence of a subfamily of eubacterial RNA polymerase sigma factors involved in the regulation of extracytoplasmic functions.

1994 • 486 citations

REGULATION OF THE HEAT-SHOCK RESPONSE IN BACTERIA

1993 • 473 citations

Regulation by proteolysis: energy-dependent proteases and their targets

1992 • 458 citations

Kinetics of Molecular Chaperone Action

1994 • 440 citations

A LOCUS THAT CONTROLS FILAMENT FORMATION AND SENSITIVITY TO RADIATION IN ESCHERICHIA COLI K-12

1964 • 436 citations

Identification of the sigma E subunit of Escherichia coli RNA polymerase: a second alternate sigma factor involved in high-temperature gene expression.

1989 • 422 citations

The heat shock response of E. coli is regulated by changes in the concentration of σ32

1987 • 414 citations

Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity.

1992 • 412 citations

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner

1990 • 407 citations

The activity of sigma E, an Escherichia coli heat-inducible sigma-factor, is modulated by expression of outer membrane proteins.

1993 • 400 citations

Transient association of newly synthesized unfolded proteins with the heat-shock GroEL protein

1988 • 388 citations

Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature

1989 • 375 citations

An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins.

1988 • 374 citations

Levels of major proteins of Escherichia coli during growth at different temperatures

1979 • 372 citations

ATP-induced protein Hsp70 complex dissociation requires K+ but not ATP hydrolysis

1993 • 366 citations

A molecular chaperone, ClpA, functions like DnaK and DnaJ.

1994 • 358 citations

DnaK, DnaJ, and GrpE heat shock proteins negatively regulate heat shock gene expression by controlling the synthesis and stability of sigma 32.

1990 • 356 citations

Regulation of the Escherichia coli heat‐shock response

1993 • 338 citations

The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP.

1995 • 325 citations

ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli. Sequence and in vivo activities.

1993 • 317 citations

The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase

1990 • 317 citations

Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor σ32

1992 • 314 citations

CIRCE, a novel heat shock element involved in regulation of heat shock operon dnaK of Bacillus subtilis

1994 • 313 citations

rpoE, the gene encoding the second heat-shock sigma factor, sigma E, in Escherichia coli.

1995 • 312 citations

Degradation of sigma 32, the heat shock regulator in Escherichia coli, is governed by HflB.

1995 • 308 citations

Two novel heat shock genes encoding proteins produced in response to heterologous protein expression in Escherichia coli

1992 • 299 citations

The rpoE gene encoding the sigma E (sigma 24) heat shock sigma factor of Escherichia coli.

1995 • 295 citations

THE UNIVERSALLY CONSERVED GroE (Hsp60) CHAPERONINS

1991 • 293 citations

Different conformations for the same polypeptide bound to chaperones DnaK and GroEL

1992 • 285 citations

The nudeotide sequence of the cloned rpoD gene for the RNA polymerase sigma subunit from E. coil K12

1981 • 262 citations

Sequence analysis and regulation of thehtrA gene ofEscherichin coli:a σ³²-independent mechanism of heat-inducible transcription

1988 • 259 citations

The two-component, ATP-dependent Clp protease of Escherichia coli. Purification, cloning, and mutational analysis of the ATP-binding component.

1988 • 256 citations

The Escherichia coli heat shock proteins GroEL and GroES modulate the folding of the beta-lactamase precursor.

1990 • 250 citations

The emergence of the chaperone machines

1992 • 249 citations

The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone.

1995 • 247 citations

Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli.

1993 • 247 citations

Interactions of bacteriophage and host macromolecules in the growth of bacteriophage lambda

1984 • 246 citations

The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein

1991 • 245 citations

The Escherichia coli dsbC (xprA) gene encodes a periplasmic protein involved in disulfide bond formation.

1994 • 241 citations

Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria.

1994 • 237 citations

Stress-induced activation of the sigma B transcription factor of Bacillus subtilis

1993 • 236 citations

The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression

1993 • 229 citations

Conversion of Pseudomonas aeruginosa to mucoidy in cystic fibrosis: environmental stress and regulation of bacterial virulence by alternative sigma factors

1994 • 221 citations

The Clp proteins: proteolysis regulators or molecular chaperones?

1992 • 216 citations

Cooperation of GroEL/GroES and DnaK/DnaJ heat shock proteins in preventing protein misfolding in Escherichia coli.

1992 • 214 citations

DnaK and DnaJ heat shock proteins participate in protein export in Escherichia coli.

1992 • 214 citations

Demonstration by genetic suppression of interaction of GroE products with many proteins

1989 • 210 citations

Escherichia coli heat shock gene mutants are defective in proteolysis.

1988 • 205 citations

Involvement of the chaperonin dnaK in the rapid degradation of a mutant protein in Escherichia coli.

1992 • 199 citations

Regulation of the promoters and transcripts of rpoH, the Escherichia coli heat shock regulatory gene.

1987 • 191 citations

Confirmation of the existence of a third family among peptidyl‐prolyl cis/trans isomerases Amino acid sequence and recombinant production of parvulin

1994 • 190 citations

Characterization of a locus determining the mucoid status of Pseudomonas aeruginosa: AlgU shows sequence similarities with a Bacillus sigma factor

1993 • 184 citations

Monomerization of RepA dimers by heat shock proteins activates binding to DNA replication origin.

1991 • 183 citations

Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation.

1989 • 180 citations

A polypeptide bound by the chaperonin groEL is localized within a central cavity.

1993 • 177 citations

Heat-shock proteins DnaK and GroEL facilitate export of LacZ hybrid proteins in E. coli

1990 • 175 citations

One member of a gro-ESL-like chaperonin multigene family in Bradyrhizobium japonicum is co-regulated with symbiotic nitrogen fixation genes.

1993 • 170 citations

Modulation of stability of the Escherichia coli heat shock regulatory factor sigma

1989 • 169 citations

Characterization of twenty-six new heat shock genes of Escherichia coli

1993 • 168 citations

surA, an Escherichia coli gene essential for survival in stationary phase

1990 • 168 citations

Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides.

1993 • 163 citations

Sequence analysis of four new heat-shock genes constituting the hslTS/ibpAB and hslVU operons in Escherichia coli

1993 • 162 citations

The nucleotide sequence of the Escherichia coli K12 dnaJ+ gene. A gene that encodes a heat shock protein.

1986 • 159 citations

A novel sigma factor is involved in expression of the rpoH gene of Escherichia coli

1989 • 159 citations

Genetics of lipopolysaccharide biosynthesis in enteric bacteria.

1993 • 158 citations

Characterization of a Functional GroEL ₁₄ (GroES ₇ ) ₂ Chaperonin Hetero-Oligomer

1994 • 154 citations

Expression of sigma 54 (ntrA)-dependent genes is probably united by a common mechanism.

1989 • 149 citations

Characterization and sequence of the Escherichia coli stress-induced psp operon

1991 • 147 citations

Role of an Escherichia coli stress-response operon in stationary-phase survival.

1994 • 145 citations

Regulation by proteolysis: energy-dependent proteases and their targets.

1992 • 143 citations

Destabilization of the complete protein secondary structure on binding to the chaperone GroEL

1994 • 142 citations

9 Properties of the Heat Shock Proteins of Escherichia coli and the Autoregulation of the Heat Shock Response

1994 • 137 citations

Stress-induced expression of the Escherichia coli phage shock protein operon is dependent on sigma 54 and modulated by positive and negative feedback mechanisms.

1991 • 135 citations

Cell growth and lambda phage development controlled by the same essential Escherichia coli gene, ftsH/hflB.

1993 • 133 citations

Both the Escherichia coli chaperone systems, GroEL/GroES and DnaK/DnaJ/GrpE, can reactivate heat-treated RNA polymerase. Different mechanisms for the same activity.

1993 • 132 citations

The Conserved G/F Motif of the DnaJ Chaperone Is Necessary for the Activation of the Substrate Binding Properties of the DnaK Chaperone

1995 • 128 citations

Autoregulation of the Escherichia coli heat shock response by the DnaK and DnaJ heat shock proteins.

1993 • 116 citations

The Cpx proteins of Escherichia coli K12

1988 • 110 citations

Bacteriophage T4 encodes a co-chaperonin that can substitute for Escherichia coli GroES in protein folding

1994 • 107 citations

8 The Function and Regulation of Heat Shock Proteins in Escherichia coli

1990 • 103 citations

hflB, a new Escherichia coli locus regulating lysogeny and the level of bacteriophage lambda cII protein

1986 • 98 citations

Interactions of bacteriophage and host macromolecules in the growth of bacteriophage lambda.

1984 • 95 citations

The deduced amino-acid sequence of the cloned cpxR gene suggests the protein is the cognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli

1993 • 95 citations

The DnaJ chaperone catalytically activates the DnaK chaperone to preferentially bind the sigma 32 heat shock transcriptional regulator.

1995 • 91 citations

Heat shock transcription of the groESL operon of Agrobacterium tumefaciens may involve a hairpin-loop structure

1993 • 85 citations

Accumulation of secretory protein precursors in Escherichia coli induces the heat shock response

1993 • 83 citations

Light‐induced carotenogenesis in Myxococcus xanthus: DNA sequence analysis of the carR region

1993 • 81 citations

Expression of the pspA gene stimulates efficient protein export in Escherichia coli

1993 • 81 citations

Induction of heat shock proteins by abnormal proteins results from stabilization and not increased synthesis of sigma 32 in Escherichia coli

1994 • 81 citations

dnaA protein regulates transcriptions of the rpoH gene of Escherichia coli

1989 • 79 citations

Both ambient temperature and the DnaK chaperone machine modulate the heat shock response in Escherichia coli by regulating the switch between sigma 70 and sigma 32 factors assembled with RNA polymerase.

1995 • 68 citations

A distinct segment of the sigma 32 polypeptide is involved in DnaK-mediated negative control of the heat shock response in Escherichia coli.

1994 • 65 citations

Isolation, characterization, and sequence of an Escherichia coli heat shock gene, htpX

1991 • 63 citations

The Escherichia coli gapA gene is transcribed by the vegetative RNA polymerase holoenzyme E sigma 70 and by the heat shock RNA polymerase E sigma 32

1994 • 62 citations

Multicopy suppression: an approach to understanding intracellular functioning of the protein export system

1992 • 56 citations

A new Escherichia coli heat shock gene, htrC, whose product is essential for viability only at high temperatures

1990 • 54 citations

The Escherichia coli heat shock gene htpY: mutational analysis, cloning, sequencing, and transcriptional regulation

1993 • 54 citations

ThehtrMgene, whose product is essential forEscherichia coliviability only at elevated temperatures, is identical to therfaDgene

1991 • 50 citations