Accumulation of secretory protein precursors in Escherichia coli induces the heat shock response

Experiments in molecular genetics

1972 • 28,260 citations

Analysis of gene control signals by DNA fusion and cloning in Escherichia coli

1980 • 2,499 citations

Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu

1976 • 1,895 citations

Improved single and multicopy lac-based cloning vectors for protein and operon fusions

1987 • 1,537 citations

Is hsp70 the cellular thermometer?

1991 • 586 citations

Production of abnormal proteins in E. coli stimulates transcription of ion and other heat shock genes

1985 • 521 citations

E. coli mutant pleiotropically defective in the export of secreted proteins

1981 • 512 citations

THE ENZYMOLOGY OF PROTEIN TRANSLOCATION ACROSS THE Escherichia coli PLASMA MEMBRANE

1991 • 442 citations

GENETIC ANALYSIS OF PROTEIN EXPORT IN ESCHERICHIA COLI K12

1985 • 432 citations

S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP

1989 • 421 citations

The heat shock response of E. coli is regulated by changes in the concentration of σ32

1987 • 414 citations

DnaK, DnaJ, and GrpE heat shock proteins negatively regulate heat shock gene expression by controlling the synthesis and stability of sigma 32.

1990 • 356 citations

The antifolding activity of SecB promotes the export of the E. coli maltose-binding protein

1988 • 326 citations

Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor σ32

1992 • 314 citations

GENETIC ANALYSIS OF PROTEIN EXPORT IN ESCHERICHIA COLI

1990 • 291 citations

Evidence for specificity at an early step in protein export in Escherichia coli

1985 • 272 citations

Mutations in a new gene, secB, cause defective protein localization in Escherichia coli

1983 • 270 citations

Sigma 32 synthesis can regulate the synthesis of heat shock proteins in Escherichia coli.

1987 • 249 citations

DnaK and DnaJ heat shock proteins participate in protein export in Escherichia coli.

1992 • 214 citations

Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domain.

1992 • 208 citations

Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation.

1989 • 180 citations

The DnaK chaperone modulates the heat shock response of Escherichia coli by binding to the sigma 32 transcription factor.

1992 • 178 citations

Induction of the heat shock regulon does not produce thermotolerance in Escherichia coli.

1987 • 177 citations

Insertion of proteins into bacterial membranes: mechanism, characteristics, and comparisons with the eucaryotic process

1989 • 167 citations

Role of RpoH, a heat shock regulator protein, in Escherichia coli carbon starvation protein synthesis and survival

1991 • 158 citations

Mutations affecting localization of an Escherichia coli outer membrane protein, the bacteriophage λ receptor

1980 • 153 citations

Mutations in the Lon gene of E. coli K12 phenotypically suppress a mutation in the sigma subunit of RNA polymerase

1983 • 78 citations

Heat-shock proteins can substitute for SecB function during protein export in Escherichia coli.

1991 • 73 citations

The synthesis of export-defective proteins can interfere with normal protein export in Escherichia coli.

1984 • 73 citations

Partial loss of function mutations in DnaK, the Escherichia coli homologue of the 70-kDa heat shock proteins, affect highly conserved amino acids implicated in ATP binding and hydrolysis.

1992 • 54 citations

Diverse effects of the MalE-LacZ hybrid protein on Escherichia coli cell physiology

1986 • 48 citations

The presence of both the signal sequence and a region of mature LamB protein is required for the interaction of LamB with the export factor SecB.

1990 • 42 citations

Characterization of a region in mature LamB protein that interacts with a component of the export machinery of Escherichia coli.

1990 • 27 citations