Blood: New designs for a new millennium

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Sickle Cell Anemia, a Molecular Disease

1949 • 2,216 citations

Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia

1995 • 2,210 citations

Correction of the Anemia of End-Stage Renal Disease with Recombinant Human Erythropoietin

1987 • 2,006 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

Structure of Hæmoglobin: A Three-Dimensional Fourier Synthesis at 5.5-Å. Resolution, Obtained by X-Ray Analysis

1960 • 1,270 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Cloning and expression of the human erythropoietin gene.

1985 • 1,144 citations

Isolation and characterization of genomic and cDNA clones of human erythropoietin

1985 • 1,101 citations

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

1985 • 1,021 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Gene Mutations in Human Hæmoglobin: the Chemical Difference Between Normal and Sickle Cell Hæmoglobin

1957 • 938 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

Purification of human erythropoietin.

1977 • 893 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Molecular Analysis of the T(14;18) Chromosomal Translocation in Malignant Lymphomas

1987 • 701 citations

Integrin Signaling: The Platelet Paradigm

1998 • 683 citations

Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. 1910.

2001 • 633 citations

Apoptosis and the Dilemma of Cancer Chemotherapy

1997 • 615 citations

Filgrastim (r-metHuG-CSF): the first 10 years

1996 • 610 citations

A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex.

1985 • 593 citations

Activating and dominant inactivating c-KITcatalytic domain mutations in distinct clinical forms of human mastocytosis

1999 • 560 citations

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

1999 • 556 citations

Platelet GPIIb-IIIa blockers

1999 • 526 citations

Christmas Disease

1952 • 424 citations

“Normal” Thrombin Generation

1999 • 380 citations

Cloning and expression of the hyman erythropoietin gene

1985 • 353 citations

Emerging Applications of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

1998 • 316 citations

Thrombopoietin

1998 • 313 citations

An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia

1998 • 307 citations

A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy

1996 • 299 citations

Negative regulation of the JAK/STAT pathway

1999 • 288 citations

Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia

1999 • 249 citations

Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease.

1996 • 233 citations

Sustained correction of bleeding disorder in hemophilia B mice by gene therapy

1999 • 223 citations

Evidence for Prevention of Death and Myocardial Infarction With Platelet Membrane Glycoprotein IIb/IIIa Receptor Blockade by Abciximab (c7E3 Fab) Among Patients With Unstable Angina Undergoing Percutaneous Coronary Revascularization fn1fn1This study was supported by Centocor, Inc., Malvern, Pennsylvania.

1997 • 217 citations

Thrombophilia as a multigenic disease.

1999 • 188 citations

The Molecular Basis of X‐Linked Severe Combined Immunodeficiency: The Role of the Interleukin‐2 Receptor γ Chain as a Common γ Chain, γc

1994 • 180 citations

Chromatin Remodeling and Leukemia: New Therapeutic Paradigms

1999 • 173 citations

Inhibition of dog platelet function by in vivo infusion of F(ab')2 fragments of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor

1985 • 172 citations

Locus control regions, chromatin activation and transcription

1998 • 142 citations

Hemophilia in the Talmud and Rabbinic Writings

1969 • 125 citations

Arabinosylcytosine Induces Fetal Hemoglobin in Baboons by Perturbing Erythroid Cell Differentiation Kinetics

1984 • 123 citations

Clinical efficacy and safety of an ABL specific tyrosine kinase inhibitor as targeted therapy for chronic myelogenous leukemia

1999 • 123 citations

Affinity Modulation of Platelet Integrin αIIbβ3 by β3-Endonexin, a Selective Binding Partner of the β3 Integrin Cytoplasmic Tail

1997 • 123 citations

Molecular analysis of the ERGIC-53 gene in 35 families with combined factor V-factor VIII deficiency.

1999 • 96 citations

ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families.

1999 • 94 citations

The emergence of Trichophyton tonsurans tinea capitis in Birmingham, U.K.

1995 • 93 citations

Molecular Analysis of the ERGIC-53 Gene in 35 Families With Combined Factor V-Factor VIII Deficiency

1999 • 89 citations

Recombinant Human Thrombopoietin in Combination With Granulocyte Colony-Stimulating Factor Enhances Mobilization of Peripheral Blood Progenitor Cells, Increases Peripheral Blood Platelet Concentration, and Accelerates Hematopoietic Recovery Following High-Dose Chemotherapy

1999 • 86 citations

Molecular Diagnosis and Carrier Screening for β Thalassemia

1997 • 66 citations

A molecular defect in thrombasthenic platelets.

1975 • 65 citations

Attenuated hematopoietic response to granulocyte-macrophage colony-stimulating factor in patients with acquired pulmonary alveolar proteinosis

1998 • 62 citations

Human urinary macrophage colony-stimulating factor reduces the incidence and duration of febrile neutropenia and shortens the period required to finish three courses of intensive consolidation therapy in acute myeloid leukemia: a double-blind controlled study.

1997 • 61 citations

Interferon-α therapy for chronic myelogenous leukemia

1995 • 46 citations

Update on the biologic effects of macrophage colony-stimulating factor

1998 • 43 citations

Human piebaldism: relationship between phenotype and site of kit gene mutation

2010 • 42 citations

A novel DNA inversion causing severe hemophilia A

1996 • 32 citations

Erythropoietin receptor mutations and Olympic glory

1993 • 31 citations

Thrombolytic Therapy

1997 • 31 citations

THE HISTORY OF HAEMOPHILIA IN THE ROYAL FAMILIES OF EUROPE

1999 • 28 citations

CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine listeriosis

1997 • 28 citations

Emerging Applications of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

1998 • 25 citations

Epoetin alfa: into the new millennium.

1998 • 19 citations

The William Allan Memorial Award address: Thalassemia: molecular mechanism and detection.

1986 • 15 citations

Recombinant Human Thrombopoietin in Combination With Granulocyte Colony-Stimulating Factor Enhances Mobilization of Peripheral Blood Progenitor Cells, Increases Peripheral Blood Platelet Concentration, and Accelerates Hematopoietic Recovery Following High-Dose Chemotherapy

1999 • 12 citations