Neutrophil Emigration, Activation, and Tissue Damage

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Free Radicals in Biology

1976 • 1,879 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

1978 • 1,117 citations

Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

1985 • 1,110 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

In Vitro Bactericidal Capacity of Human Polymorphonuclear Leukocytes: Diminished Activity in Chronic Granulomatous Disease of Childhood *

1967 • 932 citations

The respiratory burst of phagocytes.

1984 • 914 citations

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide.

1985 • 796 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

THE ISOLATION AND PROPERTIES OF THE SPECIFIC CYTOPLASMIC GRANULES OF RABBIT POLYMORPHONUCLEAR LEUCOCYTES

1960 • 708 citations

The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.

1975 • 705 citations

Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.

1987 • 699 citations

Biochemical Aspects of Phagocytosis

1961 • 657 citations

The effects of bacterial endotoxins on host mediation systems. A review.

1978 • 648 citations

The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features

1985 • 644 citations

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

1980 • 628 citations

LEUKOKINETIC STUDIES. IV. THE TOTAL BLOOD, CIRCULATING AND MARGINAL GRANULOCYTE POOLS AND THE GRANULOCYTE TURNOVER RATE IN NORMAL SUBJECTS*

1961 • 626 citations

Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

1985 • 625 citations

Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme.

1984 • 612 citations

An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.

1986 • 593 citations

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.

1986 • 576 citations

Culture of vascular endothelium.

1976 • 532 citations

Elastolytic Activity in Pulmonary Lavage Fluid from Patients with Adult Respiratory-Distress Syndrome

1981 • 528 citations

The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

1971 • 513 citations

Elastase in Tissue Injury

1985 • 512 citations

Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis.

1984 • 495 citations

Free Radical Mechanisms of Lipid Damage and Consequences for Cellular Membranes

1976 • 465 citations

Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.

1981 • 446 citations

Leukocyte Oxidase: Defective Activity in Chronic Granulomatous Disease

1967 • 425 citations

The neutrophilic leukocyte in wound repair

1972 • 400 citations

Chemotaxis and inflammation

1974 • 397 citations

THE EXTRA RESPIRATION OF PHAGOCYTOSIS

1932 • 394 citations

ELECTRON MICROGRAPHIC OBSERVATIONS ON THE EMIGRATION OF LEUCOCYTES

1960 • 388 citations

Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro.

1985 • 380 citations

The inflammatory process

1973 • 328 citations

Tumor invasion and metastases: role of the basement membrane. Warner-Lambert Parke-Davis Award lecture.

1984 • 321 citations

Biology of disease: membrane injury and calcium homeostasis in the pathogenesis of coagulative necrosis.

1982 • 316 citations

An Inherited Abnormality of Neutrophil Adhesion

1980 • 306 citations

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

1979 • 293 citations

Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils.

1986 • 283 citations

Degradation of type IV (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules.

1980 • 279 citations

Lectures on the Comparative Pathology of Inflammation.

1970 • 276 citations

Release of Gelatinase from a Novel Secretory Compartment of Human Neutrophils

1982 • 276 citations

Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of high molecular weight surface glycoproteins (GP138): common relationship to diminished cell adherence.

1984 • 273 citations

The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro

1985 • 268 citations

The Biochemical Basis of Phagocytosis

1960 • 267 citations

POLYMORPHONUCLEAR LEUKOCYTES IN IMMUNOLOGIC REACTIONS

1966 • 266 citations

Biological effects of the human complement fragments C5a and C5ades Arg on neutrophil function

1980 • 265 citations

Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals.

1981 • 260 citations

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

1984 • 253 citations

Myeloperoxidase, hydrogen peroxide, chloride antimicrobial system: nitrogen-chlorine derivatives of bacterial components in bactericidal action against Escherichia coli

1979 • 251 citations

Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion.

1984 • 249 citations

Elaboration of toxic oxygen by-products by neutrophils in a model of immune complex disease.

1976 • 249 citations

Neutrophil-endothelial cell interactions. Modulation of neutrophil adhesiveness induced by complement fragments C5a and C5a des arg and formyl-methionyl-leucyl-phenylalanine in vitro.

1984 • 248 citations

The immunologic release of constituents from neutrophil leukocytes. II. Mechanisms of release during phagocytosis, and adherence to nonphagocytosable surfaces.

1971 • 246 citations

Generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G.

1976 • 237 citations

Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes.

1972 • 236 citations

Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes.

1984 • 224 citations

Role of oxygen metabolites in immune complex injury of lung.

1981 • 224 citations

Observations on changes in blood vascular endothelium in the living animal

1935 • 221 citations

Vascular Injury and Lysis of Basement Membrane in vitro by Neutral Protease of Human Leukocytes

1968 • 211 citations

FUNCTIONAL AND METABOLIC PROPERTIES OF POLYMORPHONUCLEAR LEUCOCYTES

1960 • 210 citations

Isolation and culture of microvascular endothelium from human adipose tissue.

1983 • 207 citations

Relationship between the velocity of rolling granulocytes and that of the blood flow in venules

1973 • 205 citations

PRODUCTION OF INFLAMMATORY CHANGES IN THE MICROCIRCULATION BY CATIONIC PROTEINS EXTRACTED FROM LYSOSOMES

1964 • 198 citations

Severe recurrent bacterial infections associated with defective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein

1982 • 193 citations

THE SITE OF LEUCOCYTE EMIGRATION DURING INFLAMMATION

1961 • 190 citations

STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON

1951 • 189 citations

CHRONIC GRANULOMATOUS DISEASE: CORRELATION BETWEEN PATHOGENESIS AND CLINICAL FINDINGS

1971 • 185 citations

Oxidant injury of lung parenchymal cells.

1981 • 185 citations

Methods for microcarrier culture of bovine pulmonary artery endothelial cells avoiding the use of enzymes

1980 • 180 citations

Pathologic mechanisms in neutrophil-mediated injury.

1972 • 180 citations

Deficiency of a Granulocyte-Membrane Glycoprotein (gp150) in a Boy with Recurrent Bacterial Infections

1982 • 180 citations

The Immunologic Release of Constituents from Neutrophil Leukocytes

1971 • 177 citations

METABOLIC AND MORPHOLOGICAL OBSERVATIONS ON THE EFFECT OF SURFACE-ACTIVE AGENTS ON LEUKOCYTES

1967 • 176 citations

Na+ and K+ transport damage induced by oxygen free radicals in human red cell membranes.

1983 • 175 citations

Vascular endothelium-leukocyte interaction; sticking shear force in venules.

1975 • 174 citations

The adhesive interaction between polymorphonuclear leukocytes and endothelial cells in vitro

1978 • 172 citations

Comparative adherence of granulocytes to endothelial monolayers and nylon fiber.

1978 • 169 citations

Secreted forms of human neutrophil collagenase.

1986 • 167 citations

STUDIES ON THE PATHOGENESIS OF ACUTE INFLAMMATION

1955 • 165 citations

Evidence for hydroxyl radical generation by human Monocytes.

1977 • 152 citations

Electron microscopy of leukocytic margination and emigration in acute inflammation in dog pancreas.

1961 • 147 citations

Granulocyte activation by endotoxin. I. Correlation between adherence and other granulocyte functions, and role of endotoxin structure on biologic activity.

1983 • 145 citations

Glomerular basement membrane damage in immunological glomerulonephritis.

1968 • 145 citations

Effect of Natural Protease Inhibitors and a Chemoattractant on Tumor Cell Invasion In Vitro

1982 • 141 citations

Chemotaxis and Inflammation

1983 • 140 citations

THE STICKING AND EMIGRATION OF WHITE BLOOD CELLS IN INFLAMMATION

1973 • 133 citations

FUNCTIONAL AND METABOLIC PROPERTIES OF POLYMORPHONUCLEAR LEUCOCYTES

1960 • 129 citations

The metabolism of leukocytes.

1968 • 125 citations

Charge-related alterations of the cerebral endothelium.

1983 • 124 citations

GROWTH-PROMOTING FUNCTION OF LEUCOCYTES

1922 • 123 citations

Biochemistry of lipids.

1960 • 120 citations

Leucocyte migration from small blood vessels stimulated with ultraviolet light: An electron‐microscope study

1961 • 119 citations

Stimulation of the elastolytic activity of leukocyte elastase by leukocyte cathepsin G.

1981 • 118 citations

Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens.

1984 • 115 citations

DISTRIBUTION AND CLEARANCE OF CIRCULATING ENDOTOXIN*

1963 • 114 citations

BONE-MARROW TRANSPLANTATION FOR INBORN ERROR OF PHAGOCYTIC CELLS ASSOCIATED WITH DEFECTIVE ADHERENCE, CHEMOTAXIS, AND OXIDATIVE RESPONSE DURING OPSONISED PARTICLE PHAGOCYTOSIS

1983 • 106 citations

Suppression by superoxide dismutase of immune-complex--induced pulmonary alveolitis and dermal inflammation.

1981 • 100 citations

Commentary from Westminster

1984 • 100 citations

Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1

1985 • 98 citations

Wound Healing

1958 • 96 citations

Neutrophil specific granules: a fuse that ignites the inflammatory response.

1984 • 96 citations

Cationic proteins from human neutrophil granulocytes evidence for their chymotrypsin-like properties

1975 • 96 citations

A differential effect of C5a and C5a des Arg in the induction of pulmonary inflammation.

1980 • 95 citations

Granulocyte migration through endothelium in culture.

1979 • 91 citations

Recherches anatomiques et physiologiques sur la stricture intime des animaux et des végétaux, sur leur mobilité /

1824 • 90 citations

Paf‐acether (platelet‐activating factor) increases microvascular permeability and affects endothelium‐granulocyte interaction in microvascular beds

1983 • 86 citations

Neutrophil granulocytes: adhesion and locomotion on collagen substrata and in collagen matrices

1982 • 86 citations

Polymorphonuclear leukocyte migration through human amnion membrane

1981 • 83 citations

Neutrophil-endothelial cell interactions on endothelial monolayers grown on micropore filters.

1981 • 83 citations

Altering hydrodynamic variables influences PGI2 production by isolated lungs and endothelial cells

1984 • 83 citations

Laminin promotes rabbit neutrophil motility and attachment.

1986 • 83 citations

Lung inflammation induced by complement-derived chemotactic fragments in the alveolus.

1980 • 83 citations

Studies of intercellular invasion in vitro using rabbit peritoneal neutrophil granulocytes (PMNS). I. Role of contact inhibition of locomotion.

1975 • 81 citations

Human neutrophil laminin receptors: activation-dependent receptor expression.

1987 • 81 citations

PREVENTION OF THE LOCALIZED AND GENERALIZED SHWARTZMAN REACTIONS BY AN ANTICOMPLEMENTARY AGENT, COBRA VENOM FACTOR

1971 • 81 citations

New biological activity following intravascular activation of the complement cascade

1974 • 79 citations

Interaction of leukocytes with vascular cells in culture

1978 • 79 citations

Adhesion of neutrophil leucocytes under conditions of flow

1984 • 74 citations

Leukotriene B₄ induces extravasation and migration of polymorphonuclear leukocytes in vivo

1982 • 65 citations

Interactions of the Classical and Alternate Complement Pathway with Endotoxin Lipopolysaccharide EFFECT ON PLATELETS AND BLOOD COAGULATION

1973 • 65 citations

Studies on the pathogenesis of acute inflammation

1970 • 61 citations

LEUKOCYTIC TREPHONES

1924 • 60 citations

Chemotaxis of granulocytes across bovine pulmonary artery intimal explants without endothelial cell injury

1984 • 56 citations

Subcellular location and properties of bactericidal factors from human neutrophils.

1986 • 55 citations

Specific binding of endotoxin to human monocytes and mouse macrophages: Serum requirement

1985 • 55 citations

Neutral Proteinases from Human Inflammatory Cells: A Critical Review of Their Role in Extracellular Matrix Degradation

1983 • 55 citations

The influence of contact guidance on chemotaxis of human neutrophil leukocytes

1983 • 53 citations

Differentiated distribution of the cell surface charge on the alveolar-capillary unit

1983 • 51 citations

Interactions of neutrophil granulocytes (PMNs) and endothelium in vitro

1977 • 50 citations

Leukocytes in chemotactic-fragment-induced lung inflammation. Vascular emigration and alveolar surface migration.

1980 • 50 citations

Infections of Paramecium bursaria with bacteria and yeasts

1982 • 48 citations

Inhibition of the Biologic Effects of Endotoxin on Neutrophils by Polymyxin B Sulfate

1977 • 47 citations

Two-Dimensional and Three-Dimensional Movement of Human Polymorphonuclear Leukocytes: Two Fundamentally Different Mechanisms of Location

1986 • 46 citations

Polymorphonuclear neutrophils delay corneal epithelial wound healing in vitro.

1984 • 45 citations

A morphologic study of the influx of neutrophils into dog lung alveoli after lavage with sterile saline.

1980 • 44 citations

Contact guidance of human neutrophil leukocytes

1982 • 44 citations

The Role of Complement in Endotoxin‐Induced Disseminated Intravascular Coagulation: Studies in Congenitally C₆‐Deficient Rabbits

1974 • 43 citations

Migration of human neutrophils in hydrated collagen lattices

1982 • 42 citations

Interaction of neoplastic cells with glass surface under flow conditions

1977 • 36 citations

The interaction of Escherichia coli endotoxin with leukocytes

1969 • 33 citations

An in vitro model for polymorphonuclear-leukocyte-induced injury to an extracellular matrix. Relative contribution of oxidants and elastase to fibronectin release from amnionic membranes.

1986 • 32 citations

Pathogenesis of Emphysema and Chronic Bronchitis

1981 • 31 citations

Acetyl glyceryl ether phosphorylcholine (PAF-acether) and leukotriene B4-mediated neutrophil chemotaxis through an intact endothelial cell monolayer

1984 • 31 citations

A morphological study of the role of phagocytes in the clearance of Staphylococcus aureus from the lung.

1983 • 28 citations

The effect of complement depletion on bacterial lipopolysaccharide (LPS)-induced hemodynamic and hematologic changes in the Rhesus monkey.

1978 • 23 citations

Effect of leukotrienes on endothelium and the transendothelial migration of neutrophils

1984 • 21 citations

Interactions of the Classical and Alternate Complement Pathway with Endotoxin Lipopolysaccharide

1973 • 20 citations

Stimulants of Cellular Proliferation in Wounds

1971 • 20 citations

Polymorphonuclear activation in leprosy. I. Spontaneous and endotoxin-stimulated reduction of nitroblue tetrazolium: effects of serum and plasma on endotoxin-induced activation.

1975 • 14 citations

Facilitation of granulocyte migration into bovine pulmonary artery intimal explants by intact viable endothelium.

1984 • 13 citations

Immunoreactive Granulocyte Elastase in Rhumatoid Synovial Fluid and Membrane

1982 • 12 citations

Basic proteins in rat neutrophils that increase vascular permeability.

1970 • 10 citations

Binding of endotoxin (LPS) by glycerophosphatides from human platelets and leukocytes

1977 • 8 citations

Effect of experimental neutropenia on oral wound healing in guinea pigs

1978 • 8 citations