Activation of the Proto-Oncogene p60^c-src by Point Mutations in the SH2 Domain

Antibodies, a laboratory manual

1989 • 12,929 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Cell Transformation by the Viral src Oncogene

1987 • 405 citations

Molecular cloning and characterization of avian sarcoma virus circular DNA molecules

1980 • 361 citations

An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase

1987 • 346 citations

Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosis

1989 • 319 citations

Neuronal pp60 ^{c- src} Contains a Six-Amino Acid Insertion Relative to Its Non-Neuronal Counterpart

1987 • 313 citations

A tail of two src's: Mutatis mutandis

1987 • 278 citations

Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.

1983 • 253 citations

The Reverse Turn as a Polypeptide Conformation in Globular Proteins

1973 • 249 citations

Altered phosphorylation and activation of PP60c-src during fibroblast mitosis

1988 • 249 citations

Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses

1982 • 239 citations

Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase

1989 • 239 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

RAPID TRANSFORMATION OF CELLS BY ROUS SARCOMA VIRUS

1969 • 203 citations

Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src).

1981 • 203 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of p60src are dispensable for transformation

1983 • 189 citations

Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells.

1984 • 161 citations

Activation of the transforming potential of p60c-src by a single amino acid change.

1986 • 161 citations

Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region

1987 • 117 citations

Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants

1989 • 107 citations

A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell.

1987 • 89 citations

Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation

1982 • 83 citations

Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins.

1984 • 81 citations

Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability

1989 • 75 citations

A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner

1989 • 65 citations

Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters

1986 • 58 citations

Small deletion in src of Rous sarcoma virus modifying transformation phenotypes: identification of 207-nucleotide deletion and its smaller product with protein kinase activity

1983 • 52 citations

Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src protein

1987 • 41 citations

Activation of the c-src Gene

1986 • 25 citations

Immunological characterization of proteins detected by phosphotyrosine antibodies in cells transformed by Rous sarcoma virus

1988 • 18 citations

Characterization of partially activated p60c-src in chicken embryo fibroblasts

1989 • 5 citations