Activation of p56^lck through Mutation of a Regulatory CarboxyTerminal Tyrosine Residue Requires Intact Sites of Autophosphorylation and Myristylation

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection

1989 • 692 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation.

1985 • 386 citations

Monoclonal antibodies to phosphotyrosine

1988 • 242 citations

Specific Expression of a Tyrosine Kinase Gene, blk , in B Lymphoid Cells

1990 • 234 citations

Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts.

1988 • 208 citations

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.

1989 • 151 citations

Covalently bound myristate in a lymphoma tyrosine protein kinase.

1984 • 120 citations

Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region

1987 • 117 citations

Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.

1986 • 96 citations

A function for the lck proto-oncogene

1989 • 57 citations

src-related protein tyrosine kinases

1989 • 12 citations