Heterodimerization of the yeast MATa1 and MAT alpha 2 proteins is mediated by two leucine zipper-like coiled-coil motifs.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

X-Ray Structure of the GCN4 Leucine Zipper, a Two-Stranded, Parallel Coiled Coil

1991 • 1,433 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

The structure and function of the homeodomain

1989 • 1,007 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

1989 • 996 citations

The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex

1992 • 964 citations

Genetic Control of Flower Development by Homeotic Genes in Antirrhinum majus

1990 • 852 citations

The developmental gene Knotted-1 is a member of a maize homeobox gene family

1991 • 736 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

DNA recognition by GAL4: structure of a protein-DNA complex

1992 • 664 citations

A regulatory hierarchy for cell specialization in yeast

1989 • 612 citations

Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae.

1981 • 542 citations

Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network

1986 • 496 citations

Tat Protein from Human Immunodeficiency Virus Forms a Metal-Linked Dimer

1988 • 464 citations

Mechanism of specificity in the Fos-Jun oncoprotein heterodimer

1992 • 422 citations

Sequence of the gene for iso-l-cytochrome c in saccharomyces cerevisiae

1979 • 348 citations

The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein

1988 • 348 citations

Transcriptional regulation by dimerization: Two sides to an incestuous relationship

1990 • 343 citations

Synthetic model proteins. Positional effects of interchain hydrophobic interactions on stability of two-stranded alpha-helical coiled-coils.

1992 • 326 citations

Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins

1989 • 306 citations

An amino-terminal fragment of GAL4 binds DNA as a dimer

1989 • 296 citations

The sequence of the DNAs coding for the mating-type loci of saccharomyces cerevisiae

1981 • 286 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Structure of the leucine zipper

1992 • 282 citations

Regulation of yeast mating-type interconversion: feedback control of HO gene expression by the mating-type locus.

1983 • 280 citations

The Athb-1 and −2 HD-Zip domains homodimerize forming complexes of different DNA binding specificities.

1993 • 259 citations

A novel class of plant proteins containing a homeodomain with a closely linked leucine zipper motif.

1991 • 253 citations

HD-Zip proteins: members of an Arabidopsis homeodomain protein superfamily.

1992 • 249 citations

Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP

1989 • 237 citations

A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain

1988 • 234 citations

a1 Protein alters the dna binding specificity of α2 repressor

1988 • 218 citations

Identification and comparison of two sequence elements that confer cell-type specific transcription in yeast

1985 • 192 citations

Packing and hydrophobicity effects on protein folding and stability: Effects of β‐branched amino acids, valine and isoleucine, on the formation and stability of two‐stranded α‐helical coiled coils/leucine zippers

1993 • 173 citations

Amino-Acid Sequence of Rabbit Skeletal Tropomyosin and Its Coiled-Coil Structure

1972 • 165 citations

Plasmids pEMBLY: new single-stranded shuttle vectors for the recovery and analysis of yeast DNA sequences

1985 • 157 citations

Flexibility of the yeast alpha 2 repressor enables it to occupy the ends of its operator, leaving the center free.

1988 • 150 citations

Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region.

1986 • 148 citations

Solution structure of the POU-specific DNA-binding domain of Oct-1

1993 • 144 citations

Synthetic model proteins: the relative contribution of leucine residues at the nonequivalent positions of the 3-4 hydrophobic repeat to the stability of the two-stranded .alpha.-helical coiled-coil

1992 • 143 citations

Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy

1990 • 139 citations

Binding of yeast al and α2 as a heterodimer to the operator DNA of a haploid-specific gene

1990 • 132 citations

Cell-type-specific transcription in yeast

1991 • 125 citations

Yeast repressor alpha 2 binds to its operator cooperatively with yeast protein Mcm1.

1989 • 125 citations

Homeo Domain of the Yeast Repressor α2 Is a Sequence-Specific DNA-Binding Domain But Is Not Sufficient for Repression

1987 • 121 citations

A short, disordered protein region mediates interactions between the homeodomain of the yeast α2 protein and the MCM1 protein

1993 • 120 citations

[16] Cloning regulated yeast genes from a pool of lacZ fusions

1983 • 96 citations

Structure, function and application of the coiled-coil protein folding motif

1993 • 94 citations

Negative regulation of STE6 gene expression by the alpha 2 product of Saccharomyces cerevisiae.

1984 • 93 citations

Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization

1991 • 79 citations

Regulation of vertebrate homeobox‐containing genes by morphogens

1993 • 76 citations

Sequences upstream of the STE6 gene required for its expression and regulation by the mating type locus in Saccharomyces cerevisiae.

1986 • 70 citations

Unzipping the secrets of coiled-coils

1992 • 59 citations

Homoeo-domain homology in yeast MATα2 is essential for repressor activity

1986 • 57 citations

Secondary structure of the homeo domain of yeast alpha 2 repressor determined by NMR spectroscopy.

1991 • 57 citations

Structure of the Saccharomyces cerevisiae HO Gene and Analysis of Its Upstream Regulatory Region

1986 • 44 citations

A Simple and Efficient Procedure for Generating Random Point Mutations and for Codon Replacements Using Mixed Oligodeoxynucleotides

1988 • 38 citations

Role of the conserved leucines in the leucine zipper dimerization motif of yeast GCN4

1992 • 30 citations

Negative Regulation of STE6 Gene Expression by the α2 Product of Saccharomyces cerevisiae

1984 • 24 citations

Mating-Type Control in Saccharomyces cerevisiae: Isolation and Characterization of Mutants Defective in Repression by a1-α2

1989 • 21 citations

Use of a ligand-screening procedure to study the interaction of S. cerevisiae alpha 2 repressor with its operator sequence.

1992 • 4 citations