The mechanism of dioxin toxicity: relationship to risk assessment.

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Cancer Mortality in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin

1991 • 542 citations

Congenital Poisoning by Polychlorinated Biphenyls and Their Contaminants in Taiwan

1988 • 541 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

cDNA cloning and structure of mouse putative Ah receptor

1992 • 406 citations

2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.

1980 • 394 citations

In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1992 • 363 citations

In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1992 • 359 citations

Targets for Dioxin: Genes for Plasminogen Activator Inhibitor-2 and Interleukin-1β

1991 • 336 citations

Potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin, for producing early life stage mortality in rainbow trout (Oncorhynchus mykiss)

1991 • 295 citations

Tumour promotion by TCDD in skin of HRS/J hairless mice

1982 • 293 citations

2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action

1991 • 289 citations

Cancer mortality among workers in chemical plant contaminated with dioxin

1991 • 286 citations

Estimates of the half‐life of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in Vietnam veterans of operation ranch hand

1989 • 254 citations

The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1987 • 251 citations

In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1992 • 244 citations

A critical review of the developmental toxicity and teratogenicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin: Recent advances toward understanding the mechanism

1990 • 235 citations

Association of the dioxin receptor with the Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor

1988 • 234 citations

Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet

1979 • 232 citations

High levels of PCBs in breast milk of inuit women from arctic quebec

1989 • 215 citations

Protein-DNA Interactions at Recognition Sites for the Dioxin-Ah Receptor Complex

1989 • 215 citations

Biological Basis for Risk Assessment of Dioxins and Related Compounds

1991 • 212 citations

The steroid receptor superfamily: mechanisms of diversity

1991 • 202 citations

Enhanced Thyroxine Metabolism and High Uptake Goiters in Rats After a Single Dose of 2,3,7,8- Tetrachlorodibenzo-p-Dioxin1¹

1977 • 201 citations

Thirty-four-year mortality follow-up of BASF employees exposed to 2,3,7,8-TCDD after the 1953 accident

1990 • 177 citations

Characterization of the wasting syndrome in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1984 • 165 citations

Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.

1984 • 164 citations

Androgenic deficiency in male rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1985 • 163 citations

Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1988 • 163 citations

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.

1992 • 156 citations

Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.

1991 • 148 citations

Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.

1992 • 146 citations

Control of cytochrome P1-450 gene expression: analysis of a dioxin-responsive enhancer system.

1986 • 146 citations

Human exposure to dioxin

1991 • 145 citations

Modeling Receptor-Mediated Processes with Dioxin: Implications for Pharmacokinetics and Risk Assessment

1993 • 138 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control.

1992 • 137 citations

Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species.

1984 • 134 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Induced Changes in Immunocompetence: Possible Mechanisms

1991 • 130 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.

1992 • 126 citations

Human Health Effects of 2,4,5-T and Its Toxic Contaminants

1984 • 126 citations

Tissue distribution of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.

1979 • 122 citations

TOXICOPATHOLOGY CHARACTERISTICS OF THE HALOGENATED AROMATICS

1979 • 122 citations

Influence of the Ah locus on the humoral immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Evidence for Ah-receptor-dependent and Ah-receptor-independent mechanisms of immunosuppression

1990 • 117 citations

Dioxin induces transforming growth factor-alpha in human keratinocytes

1991 • 114 citations

Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity.

1989 • 111 citations

TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD

1990 • 111 citations

Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1989 • 110 citations

Long-term carcinogenesis studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin and hexachlorodibenzo-p-dioxins

1991 • 109 citations

The Ah Locus, A Multigene Family Necessary for Survival in A Chemically Adverse Environment: Comparison With the Immune System

1982 • 107 citations

Inhibition of the specific DNA binding activity of the dioxin receptor by phosphatase treatment.

1991 • 104 citations

Polybrominated dibenzo-p-dioxins and related compounds: Quantitative in vivo and in vitro structure-activity relationships

1987 • 104 citations

Specific binding of polyhalogenated aromatic hydrocarbon inducers of cytochrome P-450d to the cytochrome and inhibition of its estradiol 2-hydroxylase activity

1987 • 101 citations

Organization and function of a dioxin-responsive enhancer.

1990 • 99 citations

Dose-response and time course of hypothyroxinemia and hypoinsulinemia and characterization of insulin hypersensitivity in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats

1987 • 98 citations

Distribution and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in congenic strains of mice which differ at the Ah locus.

1986 • 98 citations

Coplanar PCBs in human milk in the Province of Québec, Canada: Are they more toxic than dioxin for breast fed infants?

1991 • 96 citations

Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1992 • 96 citations

[125I]2-iodo-3,7,8-trichlorodibenzo-p-dioxin-binding species in mouse liver induced by agonists for the Ah receptor: characterization and identification.

1989 • 90 citations

Comparative Ability of Various PCBs, PCDFs, and TCDD to Induce Cytochrome P450 1A1 and 1A2 Activity Following 4 Weeks of Treatment

1993 • 89 citations

Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1989 • 89 citations

Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah locus

1990 • 85 citations

Characterization of multiple forms of the Ah receptor: comparison of species and tissues

1989 • 85 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains.

1988 • 84 citations

Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo.

1992 • 83 citations

Detection and characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human colon adenocarcinoma cell line LS180

1991 • 82 citations

Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus

1991 • 82 citations

Examination of immune parameters and host resistance mechanisms in B6C3F1 mice following adult exposure to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

1990 • 78 citations

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah nonresponsive C57BL/6J mice

1991 • 76 citations

Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 1. Effects on peripheral lymphocyte subpopulations of a non-human primate (Callithrix jacchus) after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1990 • 75 citations

Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten.

1991 • 74 citations

Disposition of octachlorodibenzo-p-dioxin (OCDD) in male rats*1

1988 • 73 citations

Physiological implications of estrogen receptor modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1988 • 72 citations

Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system

1991 • 71 citations

TCDD exposure of human embryonic palatal shelves in organ culture alters the differentiation of medial epithelial cells

1991 • 69 citations

Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts

1987 • 69 citations

Placental markers of human exposure to polychlorinated biphenyls and polychlorinated dibenzofurans.

1987 • 68 citations

A Physiologically Based Pharmacokinetic Model for 2,3,7,8-Tetrabromodibenzo-p-dioxin (TBDD) in the Rat: Tissue Distribution and CYP1A Induction

1993 • 67 citations

Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7

1992 • 66 citations

Teratogenic effects of 2,3,7,8-tetrabromodibenzo-p-dioxin and three polybrominated dibenzofurans in C57BL/6N mice*1

1991 • 62 citations

Multifunctional receptor model for dioxin and related compound toxic action: possible thyroid hormone-responsive effector-linked site.

1989 • 59 citations

Comparisons of the effects of TCDD and hydrocortisone on growth factor expression provide insight into their interaction in the embryonic mouse palate

1992 • 59 citations

Key enzymes of gluconeogenesis are dose-dependently reduced in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats

1991 • 58 citations

Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor.

1991 • 56 citations

Correlation between acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and total body fat content in mammals

1990 • 56 citations

Human body burden of polychlorinated dibenzofurans associated with toxicity based on the yusho and yucheng incidents*1

1990 • 55 citations

Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 4. Effects of multiple-dose treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on peripheral lymphocyte subpopulations of a non-human primate (Callithrix jacchus)

1992 • 53 citations

Assessment of Host Resistance to Trichinella spiralis in Mice Following Preinfection Exposure to 2,3,7,8-TCDD

1994 • 49 citations

Blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in chemical workers after chloracne and in comparison groups

1991 • 45 citations

Hepatic and Gastrointestinal Effects in an Occupational Cohort Exposed to 2,3,7,8-Tetrachlorodibenzo-para-dioxin

1992 • 44 citations

Humans are a sensitive species to some of the biochemical effects of structural analogs of dioxin

1991 • 44 citations

Relative toxicity and tumor-promoting ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PCDF), and 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF) in hairless mice

1990 • 43 citations

Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans

1989 • 39 citations

Comparison of the nuclear and cytosolic forms of the Ah receptor from Hepa 1c1c7 cells: Charge heterogeneity and ATP binding properties

1991 • 38 citations

Toxicity equivalency factors for PCBs?

1991 • 37 citations

Quantitative structure-activity relationships: analysis of interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor.

1987 • 35 citations

CHARACTERIZATION AND IDENTIFICATION

1975 • 34 citations

Integration of the human lymphocyte into immunotoxicological investigations*1

1992 • 32 citations

Genetic And Molecular Aspects Of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Action

1990 • 31 citations

Human Exposure to 2,3,7,8-TCDD and Risk of Cancer

1992 • 30 citations

TCDD (2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin) causes an increase in protein tyrosine kinase activities at an early stage of poisoning in rat hepatocyte membranes

1987 • 29 citations

Comparative developmental toxicity of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD)

1992 • 29 citations

Androgen catabolism and excretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats

1988 • 29 citations

Liver cells contain constitutive DNase I-hypersensitive sites at the xenobiotic response elements 1 and 2 (XRE1 and -2) of the rat cytochrome P-450IA1 gene and a constitutive, nuclear XRE-binding factor that is distinct from the dioxin receptor.

1991 • 28 citations

Human health effects of 2,4,5-T and its toxic contaminants

1984 • 28 citations

TCDD causes stimulation of c‐ras expression in the hepatic plasma membranes in vivo and in vitro

1992 • 26 citations

TCDD Decreases Rapidly and Persistently Serum Melatonin Concentration Without Morphologically Affecting the Pineal Gland in TCDD‐Resistant Han/Wistar Rats

1991 • 24 citations

Metabolism and distribution of [¹⁴C]glucose in rats treated with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD)

1987 • 23 citations

Enhanced suppression of humoral immunity in DBA2 mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1992 • 22 citations

Ah receptor in mice genetically "nonresponsive" for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells.

1991 • 21 citations

Decreased ligand binding to the hepatic glucocorticoid and epidermal growth factor receptors after 2,3,4,7,8-pentachlorodibenzofuran and 1,2,3,4,7,8-hexachlorodibenzofuran treatment of pregnant mice

1989 • 20 citations

Protein tyrosine phosphorylations as an indicator of 2,3,7,8-tetrachloro-p-dioxin exposure in vivo and in vitro

1992 • 20 citations

The dioxin receptor: A comparison with the glucocorticoid receptor

1988 • 19 citations

Corticosterone modulates acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male Sprague-Dawley rats

1988 • 18 citations

Induction of ethoxyresorufin-O-deethylase and inhibiyion of glucocorticoid receptor binding in skin and liver of haired and hairless HRS/J mice by topically applied 2,3,7,8-tetrachlorodibenzo-p-dioxin

1990 • 16 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity: I. Similarities to Staphylococcus aureus Cowan Strain I (SAC) in the in vitro T-dependent antibody response

1991 • 15 citations

The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: Immunotoxicity and monooxygenase enzyme induction

1990 • 14 citations

Placental Markers of Human Exposure to Polychlorinated Biphenyls and Polychlorinated Dibenzofurans

1987 • 14 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces the nuclear translocation of two XRE binding proteins in mice

1993 • 12 citations

Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Volume 3

1991 • 10 citations

Liver morphology in guinea pigs fed pyrolysis products of a polychlorinated biphenyl transformer fluid continuously for 90 days

1984 • 10 citations

Multifunctional Receptor Model for Dioxin and Related Compound Toxic Action: Possible Thyroid Hormone-Responsive Effector-Linked Site

1989 • 10 citations

Response of the antral mucosa of the rat stomach to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1991 • 7 citations

Liver Cells Contain Constitutive DNase I-Hypersensitive Sites at the Xenobiotic Response Elements 1 and 2 (XRE1 and -2) of the Rat Cytochrome P-4501Al Gene and a Constitutive, Nuclear XRE- Binding Factor That Is Distinct from the Dioxin Receptor

1991 • 6 citations

Ribonuclease inhibits Ah receptor transformation in vitro

1991 • 4 citations

HUMANS ARE A SENSITIVE SPECIES TO SOME OF THE BIOCHEMICAL EFFECTS OF STRUCTURAL ANALOGS OF DIOXIN

1991 • 3 citations

Deleted Work

1955 • 0 citations

Cited By (0)

Loading...