All four core histone N-termini contain sequences required for the repression of basal transcription in yeast.

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Improved method for high efficiency transformation of intact yeast cells

1992 • 3,258 citations

A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformaion of Escherichia coli

1987 • 2,493 citations

High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.

1979 • 1,504 citations

[10] 5-Fluoroorotic acid as a selective agent in yeast molecular genetics

1987 • 1,375 citations

The "megaprimer" method of site-directed mutagenesis.

1990 • 1,174 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix.

1991 • 720 citations

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

1991 • 700 citations

A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae

1987 • 676 citations

Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones

1987 • 609 citations

[27] Preparation of high molecular weight RNA

1991 • 579 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

Chromatin reconstituted from tandemly repeated cloned DNA fragments and core histones: A model system for study of higher order structure

1985 • 469 citations

Nucleosome loss activates yeast downstream promoters in vivo

1988 • 456 citations

Glucose repression in fungi

1995 • 451 citations

Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast

1988 • 441 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

Histone Function in Transcription

1990 • 354 citations

The structure of DNA in a nucleosome.

1990 • 353 citations

Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae.

1990 • 350 citations

Use of selectively trypsinized nucleosome core particles to analyze the role of the histone “tails” in the stabilization of the nucleosome

1989 • 330 citations

Yeast histone H4 N-terminal sequence is required for promoter activation in vivo

1991 • 330 citations

The amino terminus of the yeast F1-ATPase beta-subunit precursor functions as a mitochondrial import signal.

1986 • 258 citations

Activation of the yeast HO gene by release from multiple negative controls

1987 • 257 citations

Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.

1995 • 245 citations

Role of the histone “tails” in the folding of oligonucleosomes depleted of histone H1.

1992 • 238 citations

Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast

1994 • 227 citations

Histone H3 N-terminal mutations allow hyperactivation of the yeast GAL1 gene in vivo.

1992 • 186 citations

DNA and protein determinants of nucleosome positioning on sea urchin 5S rRNA gene sequences in vitro.

1990 • 176 citations

Histone H4 and the maintenance of genome integrity.

1995 • 168 citations

Stable nucleosome positioning and complete repression by the yeast alpha 2 repressor are disrupted by amino-terminal mutations in histone H4.

1992 • 160 citations

A Negative Regulator of HO Transcription, SIN1 (SPT2), Is a Nonspecific DNA-Binding Protein Related to HMG1

1991 • 157 citations

Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo.

1993 • 144 citations

Nucleosome linking number change controlled by acetylation of histones H3 and H4.

1990 • 132 citations

Histones H2A/H2B inhibit the interaction of transcription factor IIIA with the Xenopus borealis somatic 5S RNA gene in a nucleosome.

1992 • 123 citations

Identification of a non-basic domain in the histone H4 N-terminus required for repression of the yeast silent mating loci.

1992 • 120 citations

Nucleosomal anatomy – where are the histones?

1995 • 110 citations

GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo.

1993 • 109 citations

A New Class of Histone H2A Mutations in Saccharomyces cerevisiae Causes Specific Transcriptional Defects In Vivo

1995 • 108 citations

CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle.

1992 • 99 citations

Histones as Regulators of Genes

1992 • 92 citations

Yeast histone H2A and H2B amino termini have interchangeable functions

1986 • 88 citations

A role for histones H2A/H2B in chromatin folding and transcriptional repression.

1994 • 84 citations

Organization of theGAL1–GAL10intergeaic control region chromatin

1984 • 80 citations

Upstream Activation Sequence-Dependent Alteration of Chromatin Structure and Transcription Activation of the Yeast GAL1-GAL10 Genes

1989 • 76 citations

Nucleosome loss activates CUP1 and HIS3 promoters to fully induced levels in the yeast Saccharomyces cerevisiae.

1992 • 75 citations

Yeast histone H4 and H3 N-termini have different effects on the chromatin structure of the GAL1 promoter.

1995 • 74 citations

Yeast histone H2B containing large amino terminus deletions can function in vivo

1983 • 73 citations

The path of DNA in the nucleosome

1982 • 64 citations

Nucleosome core particles suppress the thermal untwisting of core DNA and adjacent linker DNA.

1985 • 53 citations

Histones and the Regulation of Heterochromatin in Yeast

1993 • 53 citations

Studies of Nucleosome Structure

1993 • 46 citations

Yeast histone H3 and H4 N termini function through different GAL1 regulatory elements to repress and activate transcription.

1995 • 45 citations

Nucleosome structural changes during derepression of silent mating-type loci in yeast.

1993 • 29 citations

Histone hyperacetylation is accompanied by changes in DNA topology in vivo

1991 • 28 citations

Thermal unwinding of simian virus 40 transcription complex DNA.

1989 • 25 citations

Structure of the Histone Octamer Core of the Nucleosome and Its Potential Interactions with DNA

1993 • 22 citations

Nucleosome Loss Activates CUP1 and HIS3 Promoters to Fully Induced Levels in the Yeast Saccharomyces cerevisiae

1992 • 19 citations