Transcription Factors Controlling Muscle-Specific Gene Expression

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD

1989 • 1,286 citations

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

1989 • 984 citations

Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection

1990 • 957 citations

A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.

1989 • 919 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.

1989 • 863 citations

MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer

1989 • 861 citations

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

1988 • 839 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Identification of MRF4: a new member of the muscle regulatory factor gene family.

1989 • 779 citations

Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis

1989 • 662 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo

1991 • 548 citations

Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.

1990 • 508 citations

Positive autoregulation of the myogenic determination gene MyoD1

1989 • 492 citations

Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

1990 • 482 citations

Human SRF-related proteins: DNA-binding properties and potential regulatory targets.

1991 • 446 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif.

1986 • 432 citations

Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1

1991 • 421 citations

Hormones, Growth Factors, and Myogenic Differentiation

1991 • 399 citations

MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle, and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes.

1990 • 393 citations

Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.

1989 • 349 citations

Muscle-specific transcriptional activation by MyoD.

1991 • 347 citations

Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.

1990 • 334 citations

Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.

1989 • 326 citations

A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.

1985 • 305 citations

Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2.

1992 • 302 citations

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

1990 • 294 citations

The SRE: a growth factor responsive transcriptional regulator.

1990 • 287 citations

Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1

1989 • 286 citations

Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.

1990 • 278 citations

Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site.

1991 • 275 citations

The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development.

1991 • 265 citations

Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products.

1991 • 264 citations

Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor α-subunit gene

1990 • 261 citations

Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.

1992 • 250 citations

Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene.

1988 • 248 citations

Cell proliferation inhibited by MyoD1 independently of myogenic differentiation

1990 • 224 citations

Paired MyoD-binding sites regulate myosin light chain gene expression.

1991 • 216 citations

Fibroblast Growth Factor and Transforming Growth Factor β Repress Transcription of the Myogenic Regulatory Gene MyoD1

1989 • 212 citations

Effects of growth factors on myogenic differentiation

1989 • 207 citations

MyoD induces growth arrest independent of differentiation in normal and transformed cells.

1990 • 203 citations

M-CAT Binding Factor, a Novel trans-Acting Factor Governing Muscle-Specific Transcription

1990 • 193 citations

Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters

1988 • 183 citations

c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation.

1991 • 183 citations

A conserved CATTCCT motif is required for skeletal muscle-specific activity of the cardiac troponin T gene promoter.

1988 • 183 citations

Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor.

1990 • 177 citations

Muscle-specific expression of the troponin I gene requires interactions between helix-loop-helix muscle regulatory factors and ubiquitous transcription factors.

1991 • 171 citations

Transforming growth factor beta represses the actions of myogenin through a mechanism independent of DNA binding.

1991 • 167 citations

The sarcomeric actin CArG-binding factor is indistinguishable from the c-fos serum response factor.

1989 • 166 citations

Effect of cell history on response to helix–loop–helix family of myogenic regulators

1990 • 164 citations

Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis.

1991 • 159 citations

Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4.

1990 • 157 citations

Synergism in ternary complex formation between the dimeric glycoprotein p67SRF, polypeptide p62TCF and the c-fos serum response element.

1990 • 157 citations

Developmental patterns in the expression of Myf5, MyoD, myogenin, and MRF4 during myogenesis.

1991 • 150 citations

Myogenic programs of mouse muscle cell lines: expression of myosin heavy chain isoforms, MyoD1, and myogenin.

1990 • 141 citations

Delimitation and characterization of cis-acting DNA sequences required for the regulated expression and transcriptional control of the chicken skeletal alpha-actin gene.

1986 • 137 citations

Cross-Binding of Factors to Functionally Different Promoter Elements in c-fos and Skeletal Actin Genes

1989 • 135 citations

Transcriptional activation domain of the muscle-specific gene-regulatory protein myf5

1990 • 128 citations

DNA binding-induced conformational change of the yeast transcriptional activator PRTF

1990 • 119 citations

A Single Troponin T Gene Regulated by Different Programs in Cardiac and Skeletal Muscle Development

1984 • 113 citations

The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription.

1992 • 110 citations

Characterization of a promoter element required for transcription in myocardial cells.

1991 • 109 citations

The Upstream Muscle-Specific Enhancer of the Rat Muscle Creatine Kinase Gene Is Composed of Multiple Elements

1989 • 109 citations

Two nuclear factors compete for the skeletal muscle actin promoter.

1987 • 102 citations

A highly conserved enhancer downstream of the human MLC1/3 locus is a target for multiple myogenic determination factors

1990 • 96 citations

Muscle-specific (CArG) and serum-responsive (SRE) promoter elements are functionally interchangeable in Xenopus embryos and mouse fibroblasts

1989 • 93 citations

Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-T.

1990 • 92 citations

Differential trans-activation of a muscle-specific enhancer by myogenic helix-loop-helix proteins is separable from DNA binding.

1991 • 89 citations

Cell adhesion to collagen and decreased myogenic gene expression implicated in the control of myogenesis by transforming growth factor beta.

1990 • 88 citations

Repression of myogenin function by TGF-beta 1 is targeted at the basic helix-loop-helix motif and is independent of E2A products.

1992 • 88 citations

Autonomous expression of c-myc in BC3H1 cells partially inhibits but does not prevent myogenic differentiation.

1987 • 86 citations

Brain and muscle creatine kinase genes contain common TA-rich recognition protein-binding regulatory elements.

1990 • 83 citations

Inefficient homooligomerization contributes to the dependence of myogenin on E2A products for efficient DNA binding.

1991 • 81 citations

Promoter upstream elements of the chicken cardiac myosin light-chain 2-A gene interact with trans-acting regulatory factors for muscle-specific transcription.

1989 • 76 citations

Heterodimers of myogenic helix-loop-helix regulatory factors and E12 bind a complex element governing myogenic induction of the avian cardiac alpha-actin promoter.

1991 • 74 citations

DNA-binding site for two skeletal actin promoter factors is important for expression in muscle cells.

1988 • 58 citations

CC Ar GG boxes, cis-acting elements with a dual specificity

1990 • 53 citations

Domains outside of the DNA-binding domain impart target gene specificity to myogenin and MRF4.

1991 • 43 citations

The myosin light chain enhancer and the skeletal actin promoter share a binding site for factors involved in muscle-specific gene expression.

1991 • 42 citations

Adenovirus 5 E1A represses muscle-specific enhancers and inhibits expression of the myogenic regulatory factor genes, MyoD1 and myogenin.

1990 • 40 citations

Transcriptional repression of an embryo-specific muscle gene

1988 • 34 citations