Gene amplification in methotrexate-resistant mouse cells. IV. Different DNA sequences are amplified in different resistant lines

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

Rapid and efficient cosmid cloning

1981 • 1,897 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Novel bacteriophage lambda cloning vector.

1980 • 404 citations

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

1976 • 396 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Microdissection and cloning of DNA from a specific region of Drosophila melanogaster polytene chromosomes

1981 • 341 citations

[21] Transformation and preservation of competent bacterial cells by freezing

1979 • 278 citations

Chromosomes and cancer

2009 • 266 citations

An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments.

1982 • 197 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

A new method for the preparation of metaphase chromosomes for flow analysis.

1981 • 175 citations

High-resolution analysis of human peripheral lymphocyte chromosomes by flow cytometry.

1981 • 117 citations

Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases.

1980 • 100 citations

Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts.

1979 • 89 citations

Satellite DNA in large marker chromosomes of methotrexate-resistant mouse cells

1980 • 72 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 66 citations

The development of resistance to methotrexate in a mouse melanoma cell line

1979 • 63 citations

Cloning of DNA from double minutes of Y1 mouse adrenocortical tumor cells: Evidence for gene amplification

1981 • 56 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 45 citations

Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines.

1982 • 43 citations

Amplified DNA sequences in Y1 mouse adrenal tumor cells: association with double minutes and localization to a homogeneously staining chromosomal region.

1982 • 43 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 34 citations

Loss of Resistance to Methotrexate in L5178Y Mouse Leukemia Grown <italic>In Vitro</italic>

1972 • 20 citations

Variable Content of Double Minute Chromosomes Is Not Correlated with Degree of Phenotype Instability in Methotrexate-Resistant Human Cell Lines

1982 • 16 citations