Structure of the Gene for CAD, the Multifunctional Protein That Initiates UMP Synthesis in Syrian Hamster Cells

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. 1977.

1992 • 4,683 citations

Construction and characterization of new cloning vehicle. II. A multipurpose cloning system

1977 • 3,829 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Advanced bacterial genetics

1980 • 2,388 citations

Why genes in pieces?

1978 • 2,256 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

Studies on the cleavage of bacteriophage lambda DNA with EcoRI restriction endonuclease

1975 • 798 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Purification from hamster cells of the multifunctional protein that initiates de novo synthesis of pyrimidine nucleotides.

1977 • 266 citations

Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis

1976 • 228 citations

Protein X is the product of the recA gene of Escherichia coli.

1977 • 168 citations

[18] In Vitro packaging of λ dam vectors and their use in cloning DNA fragments

1979 • 162 citations

Comparative analysis of the structural organization of two closely related vitellogenin genes in X. laevis

1980 • 106 citations

The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker

1981 • 104 citations

N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis.

1979 • 95 citations

Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.

1982 • 91 citations

Biochemical genetic analysis of pyrimidine biosynthesis in mammalian cells: I. Isolation of a mutant defective in the early steps of de novo pyrimidine synthesis

1977 • 78 citations

Organization of a multifunctional protein in pyrimidine biosynthesis. Analyses of active, tryptic fragments.

1981 • 69 citations

Evidence for Two Discrete Carbamyl Phosphate Pools in Neurospora

1971 • 64 citations

Quantitative Electron Microscopy of Nucleic Acids

1978 • 58 citations

Isolation of a multifunctional complex containing the first three enzymes of pyrimidine biosynthesis in Drosophila melanogaster

1976 • 35 citations

Properties of dispersed, highly repeated DNA within and near the hamster CAD gene.

1982 • 18 citations