Antioxidants as Antiatherogens: Animal Studies

Beyond Cholesterol

1989 • 6,533 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

1993 • 2,363 citations

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Vitamin E Consumption and the Risk of Coronary Disease in Women

1993 • 2,158 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

1992 • 1,332 citations

The Pathogenesis of Atherosclerosis

1976 • 1,169 citations

Polyphenols in olive oils

1981 • 1,154 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

1981 • 1,037 citations

Antioxidant functions of carotenoids

1989 • 916 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.

1991 • 786 citations

Probucol inhibits oxidative modification of low density lipoprotein.

1986 • 633 citations

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

1990 • 621 citations

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

1984 • 547 citations

Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit) *1Incidence and development of atherosclerosis and xanthoma

1980 • 540 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

[38] Antioxidant effects of carotenoids in Vivo and in Vitro: An overview

1992 • 485 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation.

1991 • 477 citations

Defective Lipoprotein Receptors and Atherosclerosis

1983 • 469 citations

Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis.

1990 • 461 citations

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

1986 • 417 citations

Cell biology of arterial proteoglycans.

1989 • 409 citations

Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by beta-carotene.

1993 • 408 citations

Oxygen free radicals and hypercholesterolemic atherosclerosis: Effect of vitamin E

1993 • 388 citations

The antioxidant butylated hydroxytoluene protects against atherosclerosis.

1991 • 362 citations

Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide.

1991 • 331 citations

Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation

1992 • 309 citations

The pathogenesis of atherosclerosis: An overview

1991 • 306 citations

Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions.

1993 • 278 citations

The Vitamins: Fundamental Aspects in Nutrition and Health

1992 • 272 citations

Effect of Antioxidants on Oxidative Modification of LDL

1991 • 263 citations

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.

1982 • 260 citations

Effects of d-alpha-tocopherol supplementation on experimentally induced primate atherosclerosis.

1992 • 240 citations

Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.

1994 • 229 citations

Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells.

1991 • 228 citations

Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine.

1992 • 207 citations

Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor.

1991 • 190 citations

Effects of d-α-Tocopherol Supplementation on Experimentally Induced Primate Atherosclerosis

1992 • 188 citations

Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits

1991 • 178 citations

Missing Step in Man, Monkey and Guinea Pig required for the Biosynthesis of L-Ascorbic Acid

1957 • 170 citations

Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits

1992 • 165 citations

Antioxidant vitamins and low-density-lipoprotein oxidation

1993 • 159 citations

Effect of dietary oils on lipid peroxidation and on antioxidant parameters of rat plasma and lipoprotein fractions.

1992 • 158 citations

Influence of Some Factors on Development of Experimental Cholesterol Atherosclerosis

1958 • 157 citations

Oxidative modification of beta-very low density lipoprotein. Potential role in monocyte recruitment and foam cell formation.

1989 • 148 citations

Lovastatin inhibits low-density lipoprotein oxidation and alters its fluidity and uptake by macrophages: In vitro and in vivo studies

1992 • 144 citations

Inhibitory Effects of Vitamin E on Collagen Synthesis and Wound Repair

1972 • 143 citations

Probucol attenuates the development of aortic atherosclerosis in cholesterol‐fed rabbits

1989 • 142 citations

Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.

1982 • 135 citations

Cholesterol: Vitamin C Controls Its Transformation to Bile Acids

1973 • 131 citations

Probucol inhibits neointimal thickening and macrophage accumulation after balloon injury in the cholesterol-fed rabbit.

1992 • 130 citations

Olive Oil: A Review

1988 • 129 citations

Antioxidant treatment inhibits the development of intimal thickening after balloon injury of the aorta in hypercholesterolemic rabbits.

1993 • 119 citations

Hepatic 7α-hydroxylation of cholesterol in ascorbate-deficient and ascorbate-supplemented guinea pigs

1976 • 118 citations

A rat mutant unable to synthesize vitamin C

1984 • 118 citations

Antioxidant activity of probucol and its analogs in hypercholesterolemic Watanabe rabbits

1991 • 116 citations

Mechanisms of HDL reduction after probucol. Changes in HDL subfractions and increased reverse cholesteryl ester transfer.

1989 • 113 citations

Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors.

1992 • 110 citations

Attenuation of atherosclerosis in a modified strain of hypercholesterolemic Watanabe rabbits with use of a probucol analogue (MDL 29,311) that does not lower serum cholesterol.

1991 • 106 citations

Lack of effect of probucol on atheroma formation in cholesterol-fed rabbits kept at comparable plasma cholesterol levels

1989 • 102 citations

Studies on Vitamin E Deficiency in Chicks

1944 • 100 citations

Vitamin E, Antioxidants and Lipid Peroxidation in Experimental Atherosclerosis of Rabbits

1978 • 100 citations

Inhibition by probucol of interleukin 1 secretion and its implication in atherosclerosis

1988 • 99 citations

ASCORBIC ACID IN CHOLESTEROL AND BILE ACID METABOLISM

1975 • 95 citations

Inhibition of IL-1β expression in THP-1 cells by probucol and tocopherol

1991 • 94 citations

Increase in plasma cholesteryl ester transfer protein during probucol treatment. Relation to changes in high density lipoprotein composition.

1991 • 94 citations

The effects of probucol on the progression of atherosclerosis in mature Watanabe heritable hyperlipidaemic rabbits

1991 • 93 citations

Butylated hydroxyanisole in perspective

1991 • 91 citations

Lipids of olives

1977 • 85 citations

Probucol and atherosclerosis in the Watanabe heritable hyperlipidemic rabbit — long-term antiatherogenic effect and effects on established plaques

1992 • 77 citations

An experimental study of intimal ground substance in atherosclerosis.

1953 • 76 citations

Ex vivo lipopolysaccharide‐induced interleukiri‐1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties

1990 • 74 citations

Probucol treatment affects the cellular composition but not anti-oxidized low density lipoprotein immunoreactivity of plaques from Watanabe heritable hyperlipidemic rabbits.

1991 • 73 citations

Development of accelerated atherosclerosis. Concepts derived from cell biology and animal model studies.

1983 • 70 citations

Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E

1989 • 66 citations

Lowered cholesterol catabolism in guinea pigs with chronic ascorbic acid deficiency

1971 • 63 citations

Effect of dietary vitamin E on plasma lipids and atherogenesis in restricted ovulator chickens

1989 • 63 citations

The reversibility of atherosclerosis.

1957 • 62 citations

Effect of Ascorbic Acid on Certain Blood Fat Metabolism Factors in Animals and Man

1967 • 61 citations

The use of crocetin in experimental atherosclerosis

1975 • 60 citations

Influence of Chronic Ascorbic Acid Deficiency and Excessive Ascorbic Acid Intake on Bile Acid Metabolism and Bile Composition in the Guinea Pig

1981 • 57 citations

Prevention of atherosclerotic progression in Watanabe rabbits by probucol

1988 • 57 citations

Dietary Ascorbic Acid Depresses Plasma and Low Density Lipoprotein Lipid Peroxidation in Genetically Scorbutic Rats

1992 • 56 citations

Oxidatively modified human low-density lipoprotein stimulates leukocyte adherence to the microvascular endothelium in vivo

1991 • 55 citations

Ascorbic acid and glycosaminoglycan and lipid metabolism in guinea pigs fed normal and atherogenic diets

1975 • 55 citations

Marginal Vitamin C Deficiency, Lipid Metabolism, and Atherogenesis

1978 • 52 citations

Influence of 4,4'-(Isopropylidenedithio)bis(2,6-di-t-butylphenol) (DH-581) on Experimental Atherosclerosis in Rabbits

1971 • 51 citations

Combined effects of cholestyramine and probucol on regression of atherosclerosis in rhesus monkey aortas.

1983 • 51 citations

Oxygen diffusion and atherosclerosis

1974 • 50 citations

Antiatherosclerotic effects of antioxidants are lesion-specific when evaluated in hypercholesterolemic New Zealand White rabbits

1992 • 45 citations

Pharmacology and toxicology of probucol.

1982 • 44 citations

The effect of chronic hypovitaminosis C on the metabolism of cholesterol and atherogenesis in guinea pigs

1969 • 44 citations

Effect of Probucol, Pantethine and Their Combinations on Serum Lipoprotein Metabolism and on the Incidence of Atheromatous Lesions in the Rabbit

1986 • 44 citations

Estimate of the maximal daily dietary intake of butylated hydroxyanisole and butylated hydroxytoluene in The Netherlands

1990 • 43 citations

Probucol inhibits mononuclear cell adhesion to vascular endothelium in the cholesterol-fed rabbit

1993 • 42 citations

The Influence of Chronic Vitamin C Deficiency on Fatty Acid Composition of Blood Serum, Liver Triglycerides and Cholesterol Esters in Guinea Pigs

1969 • 42 citations

Fettlösliche Vitamine und Atherosklerose

1956 • 42 citations

Probucol enhances cholesterol efflux from cultured human skin fibroblasts

1988 • 42 citations

Vitamin C: Recent Aspects of its Physiological and Technological Importance

1975 • 42 citations

Changes in the sterol composition of olive oil on heating

1975 • 41 citations

Role of biologically modified low-density lipoprotein in atherosclerosis

1989 • 41 citations

Actions of vitamins A and E and some nicotinic acid derivatives on plasma lipids and on lipid infiltration of aorta in cholesterol-fed rabbits

1975 • 38 citations

Hypercoagulable state in the Watanabe heritable hyperlipidemic rabbit, an animal model for the progression of atherosclerosis. Effect of probucol on coagulation.

1989 • 36 citations

Alimentary Exudative Diathesis, a Consequence of E-avitaminosis

1939 • 35 citations

Anti-Atherosklerotische Wirkung fettl�slicher Vitamine

1955 • 34 citations

Quantification of lowered cholesterol oxidation in guinea pigs with latent vitamin C deficiency

1973 • 34 citations

TISSUE CHANGES INDUCED BY MARGINAL VITAMIN C DEFICIENCY^*

1975 • 33 citations

Changes in high-density lipoprotein subfraction distribution and increased cholesteryl ester transfer after probucol

1988 • 32 citations

Vitamin C increases the prostacyclin production and decreases the vascular lesions in experimental atherosclerosis in rabbits

1986 • 31 citations

Bile acid metabolism in ascorbic acid-deficient guinea pigs

1979 • 31 citations

Endothelial changes produced by ascorbic acid deficiency in guinea pigs.

1965 • 30 citations

Atherosclerosis in Cholesterol-Fed Japanese Quail: Evidence for Amelioration by Dietary Vitamin E

1982 • 30 citations

Model of chronic hypovitaminosis C in guinea-pigs.

1968 • 30 citations

Ascorbic acid and cholesterol: Effect of graded oral intakes on cholesterol conversion to bile acids in guinea-pigs

1976 • 30 citations

Influence of probucol on early experimental atherogenesis in hypercholesterolemic rats

1989 • 28 citations

EXPERIMENTAL ATHEROSCLEROSIS WITH ASCORBIC ACID DEFICIENCY

1971 • 27 citations

STUDIES ON THE LIPID CONTENT OF NORMAL AND DYSTROPHIC RABBITS

1938 • 27 citations

Hypercoagulable State in the Watanabe Heritable Hyperlipidemic Rabbit, an Animal Model for the Progression of Atherosclerosis

1989 • 27 citations

Effects of Levels of Certain Dietary Lipids on Plasma Cholesterol and Atherosclerosis in the Chick

1962 • 27 citations

Aortic Acid Mucopolysaccharides and Collagen in Scorbutic Guinea Pigs

1965 • 26 citations

Antiatherosklerotische Wirkstoffe

1956 • 25 citations

Lipids of Muscle and Brain in Rats Deprived of Tocopherol

1943 • 25 citations

The effects of high levels of vitamin E on the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit

1993 • 25 citations

The Effect of Alpha Tocopherol on Experimental Atherosclerosis

1952 • 25 citations

Effect of Vitamin C Depletion on Serum Cholesterol and Lipoprotein Levels in ODS (od/od) Rats Unable to Synthesize Ascorbic Acid

1990 • 24 citations

Metabolic studies on scorbutic guinea pigs. 3. Catabolism of [4-14C]cholesterol in vivo and in vitro

1963 • 23 citations

Antiatherosklerotische Wirkung von Vitamin-A-verbindungen, Nicotinsäure, β-Pyridyl-Verbindungen und Arachidonsäure

1962 • 21 citations

Effect of Dietary Ascorbic Acid, Cholesterol and PCB on Cholesterol and Bile Acid Metabolism in a Rat Mutant Unable to Synthesize Ascorbic Acid

1989 • 21 citations

Antiatherosclerotic effect of probucol in WHHL rabbits: are there plasma parameters to evaluate this effect?

1991 • 21 citations

Aortic lesions in nonlaying hens with endogenous hyperlipidemia.

1980 • 20 citations

Experimental Atherosclerosis. VII. Effect of Vitamin E

1945 • 20 citations

Ineffectiveness of Vitamin E in Preventing Cholesterol Deposition in the Aorta

1944 • 19 citations

Parabolic Response of Hepatic Microsomal Hydroxylating System and Lipids to Graded Doses of Ascorbic Acid in Guinea Pigs on Low and High α-Tocopherol Intake

1984 • 18 citations

Probucol, high-density lipoprotein metabolism and reverse cholesterol transport

1988 • 18 citations

Effect of vitamin C administration on serum & aortic lipid profile of guineapigs.

1988 • 17 citations

Plasma lipid peroxidation in hyperlipidemic chickens

1985 • 16 citations

The effect of massive doses of ascorbic acid and methionine on the levels of lipids and glycosaminoglycans in the aorta of weanling rats

1974 • 15 citations

Stimulation of [26-¹⁴C]cholesterol oxidation by ascorbic acid in scorbutic guinea-pigs

1972 • 14 citations

Influence of vitamin C on the metabolism of arachidonic acid and the development of aortic lesions during experimental atherosclerosis in rabbits.

1984 • 14 citations

Effect of ascorbic acid on serum lipid levels and depot cholesterol of the baboon (Papio ursinus).

1975 • 13 citations

Raised ascorbic acid consumption in cholesterol-fed guinea pigs.

1972 • 13 citations

Metabolism of [1-14C] acetate in guinea pigs with chronic vitamin C hyposaturation

1969 • 13 citations

Metabolism of L-Ascorbic Acid-l-14C in Guinea Pigs with Alimentary Cholesterol Atheromatosis

1971 • 13 citations

Cholesteremia in Japanese quail: response to a mixture of vitamins C and E and choline chloride.

1979 • 12 citations

THE EFFECT OF ASCORBIC ACID ON EXPERIMENTAL ATHEROSCLEROSIS.

1964 • 12 citations

Chronic Vitamin C Deficiency Lowers Fractional Catabolic Rate of Low‐Density Lipoproteins in Guinea Pigs

1987 • 12 citations

Intimal Lesions in Arteries of Vit. E Deficient Rats.

1960 • 12 citations

Effect of ascorbic acid deficiency on the development of experimental atherosclerosis.

1987 • 11 citations

The effects of vitamine C on lipid metabolism.

1975 • 11 citations

Effects of Ascorbic Acid and its 2-Sulfate on Rabbit Aortic Intimal Thickening

1977 • 10 citations

Phospholipids associated with vitamin C in experimental atherosclerosis.

1980 • 8 citations

Hexosamine and Hydroxyproline Contents of Tissues in Scurvy.

1961 • 8 citations

Plasma lipids in ascorbic acid-deficient rhesus monkeys

1965 • 8 citations

Einflu� von Ascorbins�ure auf die Hypercholesterin�mie bei Hypothyreose

1973 • 7 citations

Elevation of serum cholesterol levels in mice by the antioxidant butylated hydroxyanisole

1993 • 6 citations

Cholesterol-Ascorbic Acid Relationship; Changes in Plasma and Cell Ascorbic Acid and Plasma Cholesterol Following Administration of Ascorbic Acid and Cholesterol

1957 • 6 citations

Die Wirkung der 1-Ascorbinsäure auf die Hypercholesterinaemie bei der experimentellen Cholestase und der Aminonucleosidnephrose

1975 • 5 citations

The effect of simultaneous treatment with thyroxine and ascorbic acid precursors on serum cholesterol concentration

1972 • 4 citations

Anti-atherosclerotic substances.

1956 • 4 citations

The effect of vitamin C on the rapid induction of aortic changes in rabbits.

1982 • 4 citations