Marginal Vitamin C Deficiency, Lipid Metabolism, and Atherogenesis

Clofibrate and Niacin in Coronary Heart Disease

1975 • 1,660 citations

The physicochemical basis of cholesterol gallstone formation in man

1968 • 1,056 citations

The Metabolic Role of Lecithin: Cholesterol Acyltransferase: Perspectives from Pathology

1973 • 480 citations

DISTRIBUTION OF ASCORBIC ACID, METABOLITES AND ANALOGUES IN MAN AND ANIMALS

1975 • 435 citations

Evolution and the Biosynthesis of Ascorbic Acid

1973 • 423 citations

Diminished Bile Acid Pool Size in Patients with Gallstones

1970 • 378 citations

Turnover of plasma cholesterol in man

1968 • 295 citations

Experimental Scurvy in Man

1969 • 236 citations

Distribution and turnover of cholesterol in humans

1969 • 214 citations

TISSUE CHANGES IN VITAMIN DEFICIENCIES

1942 • 201 citations

Evolution and the Need for Ascorbic Acid

1970 • 184 citations

EFFECT OF DIABETES AND INSULIN ON THE ACTIVITY OF MYOCARDIAL AND ADIPOSE TISSUE LIPOPROTEIN LIPASE OF RATS*

1963 • 182 citations

Missing Step in Man, Monkey and Guinea Pig required for the Biosynthesis of L-Ascorbic Acid

1957 • 170 citations

FUNCTION OF ASCORBIC ACID IN COLLAGEN METABOLISM

1975 • 161 citations

Sites of control of hepatic cholesterol biosynthesis

1966 • 159 citations

Influence of Some Factors on Development of Experimental Cholesterol Atherosclerosis

1958 • 157 citations

Cholesterol: Vitamin C Controls Its Transformation to Bile Acids

1973 • 131 citations

Hepatic 7α-hydroxylation of cholesterol in ascorbate-deficient and ascorbate-supplemented guinea pigs

1976 • 118 citations

BONE-MARROW TRANSPLANTATION IN ACUTE LEUKÆMIA

1977 • 116 citations

ISCHÆMIC-HEART-DISEASE MORTALITY AND DIETARY INTAKE OF CALCIUM

1973 • 116 citations

THE VITAMIN C CONTENT OF HUMAN TISSUES

1934 • 101 citations

ASCORBIC ACID IN CHOLESTEROL AND BILE ACID METABOLISM

1975 • 95 citations

ATHEROSCLEROSIS AND VITAMIN C

1971 • 91 citations

THE METABOLISM OF 1-C14-l-ASCORBIC ACID IN GUINEA PIGS

1951 • 83 citations

Composition of tissue lipids and anaemia of guinea pigs in response to dietary cholesterol

1964 • 80 citations

An experimental study of intimal ground substance in atherosclerosis.

1953 • 76 citations

The absence of plasma free fatty acid response to epinephrine in vitamin-C-deprived guinea pigs

1962 • 75 citations

Plasma and leukocyte ascorbic acid levels in the elderly

1974 • 72 citations

C14-CHOLESTEROL

1952 • 72 citations

EFFECTS OF ASCORBIC ACID ON MICROSOMAL DRUG METABOLISM^*

1975 • 67 citations

Studies on the biosynthesis of cholesterol 6. Coenzyme requirements of liver enzymes for synthesis of squalene and of sterol from <scp>dl</scp>-3-hydroxy-3-methyl-[2-14C]pentano-5-lactone

1958 • 66 citations

Enzymes of the arterial wall

1962 • 65 citations

Lowered cholesterol catabolism in guinea pigs with chronic ascorbic acid deficiency

1971 • 63 citations

Leucocyte ascorbic acid levels after acute myocardial infarction.

1972 • 63 citations

The reversibility of atherosclerosis.

1957 • 62 citations

ASCORBIC ACID AND COLLAGEN SYNTHESIS IN CULTURED FIBROBLASTS

1975 • 62 citations

Tissue distribution of cholesterol feedback control in the guinea pig.

1975 • 61 citations

Effect of Ascorbic Acid on Certain Blood Fat Metabolism Factors in Animals and Man

1967 • 61 citations

Plasma lipoproteins of cholesterol-fed guinea pigs

1971 • 60 citations

Seasonal variation in serum lipids, and incidence and mortality of ischaemic heart disease

1968 • 59 citations

The role of ascorbic acid in the regulation of cholesterol metabolism and in the pathogenesis of atherosclerosis

1976 • 59 citations

Ascorbic acid and glycosaminoglycan and lipid metabolism in guinea pigs fed normal and atherogenic diets

1975 • 55 citations

SAFETY CONSIDERATIONS WITH HIGH ASCORBIC ACID DOSAGE

1975 • 55 citations

The Effect of Ascorbic Acid on Cholesterolemia in Healthy Subjects with Seasonal Deficit of Vitamin C

1970 • 53 citations

Quantification of plasma cholesterol and triglyceride levels in hypercholesterolemic subjects receiving ascorbic acid supplements

1975 • 47 citations

Stimulation of Reparative Processes Following Experimental Myocardial Infarction

1966 • 45 citations

EFFECT OF ASCORBIC ACID DEFICIENCY ON THE PERMEABILITY AND COLLAGEN BIOSYNTHESIS OF ORAL MUCOSAL EPITHELIUM^*

1975 • 44 citations

The effect of chronic hypovitaminosis C on the metabolism of cholesterol and atherogenesis in guinea pigs

1969 • 44 citations

The effect of ascorbic acid in vitro on the rat ovarian cholesterol side chain cleavage enzyme system

1968 • 43 citations

Effect of ascorbic acid on plasma cholesterol in humans in a long-term experiment.

1977 • 42 citations

The Influence of Chronic Vitamin C Deficiency on Fatty Acid Composition of Blood Serum, Liver Triglycerides and Cholesterol Esters in Guinea Pigs

1969 • 42 citations

Vitamin C: Recent Aspects of its Physiological and Technological Importance

1975 • 42 citations

EFFECT OF ASCORBIC ACID ON AMINE‐NITRITE TOXICITY

1975 • 40 citations

Effect of Experimental Hypertriglyceridaemia on Tissue and Serum Lipoprotein Lipase Activity

1970 • 40 citations

SIGNIFICANCE OF FERROUS ION AND ASCORBIC ACID IN THE OPERATION OF THE TRICARBOXYLIC ACID CYCLE

1955 • 40 citations

Preface

1924 • 37 citations

RELATION OF SCURVY TO GLUCOSE TOLERANCE TEST, LIVER GLYCOGEN, AND INSULIN CONTENT OF PANCREAS OF GUINEA PIGS

1947 • 36 citations

Effect of Dietary Fat, Protein, Cholesterol and Ascorbic Acid on Performance, Serum and Tissue Cholesterol Levels and Serum Lipid Levels of Swine

1969 • 35 citations

Ascorbic acid content of human arterial tissue.

1955 • 35 citations

ASCORBIC ACID REQUIREMENTS AND METABOLISM IN RELATION TO ORGANOCHLORINE PESTICIDES^*

1975 • 34 citations

Effects of ascorbic acid on the side-chain cleavage of cholesterol

1970 • 34 citations

Quantification of lowered cholesterol oxidation in guinea pigs with latent vitamin C deficiency

1973 • 34 citations

TISSUE CHANGES INDUCED BY MARGINAL VITAMIN C DEFICIENCY^*

1975 • 33 citations

CHANGES IN ASCORBIC ACID METABOLISM OF THE OFFSPRING FOLLOWING HIGH MATERNAL INTAKE OF THIS VITAMIN IN THE PREGNANT GUINEA PIG^*

1975 • 32 citations

ASCORBIC ACID AND SERUM-CHOLESTEROL

1970 • 32 citations

ANEMIA CAUSED BY FEEDING CHOLESTEROL TO GUINEA PIGS

1939 • 31 citations

Ascorbic acid and cholesterol: Effect of graded oral intakes on cholesterol conversion to bile acids in guinea-pigs

1976 • 30 citations

THE PERIPHERAL VASCULAR SYSTEM AND ITS REACTIONS IN SCURVY: AN EXPERIMENTAL STUDY

1947 • 29 citations

ASCORBIC ACID DEFICIENCY AND CHOLESTEROL SYNTHESIS¹

1953 • 29 citations

Participation of P-450 in 7α-Hydroxylation of Cholesterol*

1968 • 29 citations

RAPID REVERSION OF ELECTROCARDIOGRAPHIC ABNORMALITIES AFTER TREATMENT IN TWO CASES OF SCURVY

1967 • 28 citations

EXPERIMENTAL ATHEROSCLEROSIS WITH ASCORBIC ACID DEFICIENCY

1971 • 27 citations

In vivo sulfation of cholesterol by ascorbic acid 2-sulfate

1973 • 27 citations

VITAMIN C AND DEEP-VEIN THROMBOSIS

1973 • 27 citations

Effect of Vitamin C on Serum Cholesterol in Patients with Hypercholesterolemia and Arteriosclerosis

1964 • 27 citations

Aortic Acid Mucopolysaccharides and Collagen in Scorbutic Guinea Pigs

1965 • 26 citations

The effect of vitamin c supplements on serum cholesterol, coagulation, fibrinolysis and platelet adhesiveness

1975 • 26 citations

Serum cholesterol in vitamin C deficiency in man

1963 • 25 citations

Observations with the scanning electron microscope on the development of cholesterol aortic atherosclerosis in the guinea-pig

1971 • 25 citations

Aortic endothelial mitosis and evans blue uptake in cholesterol-fed subscorbutic guinea-pigs

1975 • 24 citations

RELATIONSHIPS OF ASCORBIC ACID TO PREGNANCY, AND ORAL CONTRACEPTIVE STEROIDS^*

1975 • 24 citations

Metabolic studies on scorbutic guinea pigs. 3. Catabolism of [4-14C]cholesterol in vivo and in vitro

1963 • 23 citations

Estimation of the rate of breakdown of cholesterol in man by measurement of 14CO-2 excretion after intravenous [26-14C]cholesterol.

1966 • 22 citations

Comparative Studies on the Influence of L-Ascorbate, D-arabino-Ascorbate and 5-Oxo-D-gluconate on the Amounts of Cytochromes P-450 andb₅in Liver Microsomes of Guinea Pigs

1973 • 22 citations

Abnahmen der Cytochromgehalte und Veränderungen der Kinetik der Monooxygenase in Lebermikrosomen von Meerschweinchen bei verschiedenen Stadien des Ascorbinsäuremangels

1972 • 21 citations

Effect of Dietary Ascorbic Acid on Performance and Plasma Cholesterol Levels of Growing Swine

1970 • 20 citations

Lipoprotein Lipase Activity in Heart, Diaphragm and Adipose Tissue in Rats Fed Various Carbohydrates

1974 • 20 citations

THE INCORPORATION OF ACETATE-1-C14 INTO CHOLESTEROL AND FATTY ACIDS BY SURVIVING TISSUES OF NORMAL AND SCORBUTIC GUINEA PIGS

1956 • 20 citations

Adrenal Cholesterol in the Scorbutic Guinea Pig

1951 • 20 citations

THE RECOMMENDED DIETARY ALLOWANCES FOR ASCORBIC ACID

1975 • 19 citations

Experimental cholesterol arteriosclerosis II. Changes produced in golden hamsters and in guinea pigs

1950 • 19 citations

ASCORBIC ACID AND CYTOCHROMES^*

1975 • 19 citations

Cholesterol Metabolism in Scorbutic Guinea Pigs

1958 • 18 citations

Inactivation of Hormone-sensitive Lipase from Adipose Tissue with Adenosine Triphosphate, Magnesium, and Ascorbic Acid

1973 • 18 citations

VITAMIN C AND SERUM-CHOLESTEROL

1972 • 18 citations

CARBOHYDRATE METABOLISM IN THE ASCORBIC ACID-DEFICIENT GUINEA PIG UNDER NORMAL AND ANOXIC CONDITIONS

1946 • 17 citations

Influence of vitamin C on hydroxylation and side chain oxidation of cholesterol in vitro

1973 • 17 citations

Apparent sulfation of glycosaminoglycans by ascorbic acid 2-[3 5S]Sulfate: An explanation

1975 • 17 citations

Ascorbic acid and cholesterol levels in pastoral peoples in Kenya

1974 • 17 citations

Effect of ascorbic acid on lipoprotein lipase activity.

1974 • 16 citations

ACTIVATION OF PROLYL HYDROXYLASE IN FIBROBLASTS BY ASCORBIC ACID

1975 • 16 citations

Biliary Lipids during Vitamin C Feeding in Healthy Persons

1975 • 16 citations

Data Analysis Strategy for Nutritional Survey of 642 New York City School Children

1967 • 15 citations

The effect of massive doses of ascorbic acid and methionine on the levels of lipids and glycosaminoglycans in the aorta of weanling rats

1974 • 15 citations

EFFECT OF SCURVY ON CHOLESTEROL AND ASCORBIC ACID IN GUINEA PIG ADRENALS

1951 • 14 citations

Stimulation of [26-¹⁴C]cholesterol oxidation by ascorbic acid in scorbutic guinea-pigs

1972 • 14 citations

Ascorbic acid and cholesterol levels in pastoral peoples in Kenya1

1974 • 14 citations

Effect of ascorbic acid on serum lipid levels and depot cholesterol of the baboon (Papio ursinus).

1975 • 13 citations

The Influence of Vitamin C Level Upon Resistance to Diphtheria Toxin

1935 • 13 citations

Metabolism of [1-14C] acetate in guinea pigs with chronic vitamin C hyposaturation

1969 • 13 citations

Raised ascorbic acid consumption in cholesterol-fed guinea pigs.

1972 • 13 citations

Metabolism of L-Ascorbic Acid-l-14C in Guinea Pigs with Alimentary Cholesterol Atheromatosis

1971 • 13 citations

Microscopic and Biochemical Observations of Aortae of Turkeys Fed Copper-deficient Diets with and without Ascorbic Acid

1971 • 12 citations

EFFECTS OF ASCORBIC ACID ON HEALTH PARAMETERS IN GUINEA PIGS^*

1975 • 12 citations

Glycosaminoglycans and arterial disease.

1975 • 12 citations

Vitamin C and plasma triglycerides in experimental animals and in humans

1976 • 12 citations

RELATIONSHIPS OF PROTEIN AND MINERAL INTAKE TO <scp>l</scp>‐ASCORBIC ACID METABOLISM, INCLUDING CONSIDERATIONS OF SOME DIRECTLY RELATED HORMONES^*

1975 • 11 citations

Experimental Arteriosclerosis: Inhibitory Effects of Ascorbic Acid and Inositol

1952 • 11 citations

Effect of biotin and ascorbic acid on the development of atherosclerosis in rabbits

1971 • 11 citations

Subclinical scurvy--hypovitaminosis C.

1972 • 11 citations

The physiological properties of ascorbic acid

1939 • 11 citations

The effects of vitamine C on lipid metabolism.

1975 • 11 citations

SOME ASPECTS OF CURRENT VITAMIN C USAGE: DIMINISHED HIGH‐ALTITUDE RESISTANCE FOLLOWING OVERDOSAGE^*

1975 • 11 citations

Relationship Between the Dose of Ascorbic Acid and its Structural Analogs and Proline Hydroxylation in Various Biological Systemst

1974 • 10 citations

The effect of dietary ascorbic acid on cholesterol biosynthesis in vitro

1974 • 10 citations

Plasma Lipids in Scurvy: Effect of Ascorbic Acid Supplement and Insulin Treatment.

1963 • 10 citations

Metabolism of acetate in scorbutic guinea pigs

1960 • 10 citations

Cardiomegaly and generalized oedema due to vitamin C deficiency.

1974 • 9 citations

Einfluß von Ascorbinsäure auf die Induktion der Monooxygenase in den Lebermikrosomen

1970 • 9 citations

The influence of various dietary ascorbic acid levels on serum ascorbic acid and serum cholesterol values of the baboon (Papio ursinus) during captivity.

1973 • 8 citations

Effect of feeding excess of vitamin A and vitamin C on liver, plasma and adrenal lipids of rats.

1974 • 8 citations

Hexosamine and Hydroxyproline Contents of Tissues in Scurvy.

1961 • 8 citations

[Prevention and therapy of atherosclerosis with ascorbic acid].

1956 • 8 citations

Experimental atherosclerosis. 2. Effect of thiamine hydrochloride and ascorbic acid on experimental atherosclerosis in rabbits.

1941 • 7 citations

Einflu� von Ascorbins�ure auf die Hypercholesterin�mie bei Hypothyreose

1973 • 7 citations

Effect of ascorbic acid on serum cholesterol levels and on die-away curves of 14C-4-cholesterol in baboons.

1974 • 7 citations

BIOLOGICAL VARIATION IN ASCORBIC ACID NEEDS

1975 • 7 citations

Oxidation of acetate by liver preparations from guinea-pigs under scurvy

1961 • 7 citations

Fundamental studies on physiological and pharmacological actions of L-ascorbate 2-sulfate. I. On the hypolipidemic effects.

1976 • 7 citations

METABOLISM OF CHOLESTEROL IN SCORBUTIC GUINEA PIGS

1954 • 6 citations

Tissue lipids in ascorbic-acid-deficient guinea pigs.

1944 • 6 citations

Studies in experimental atherosclerosis. V. Therapeutic effect of ascorbic acid and vitamin B12 in cholesterol atherosclerosis.

1957 • 6 citations

Plasma free fatty acids in fasting vitamin c-deprived guinea pigs

1961 • 6 citations

SCURVY IN GUINEA PIGS AS A CAUSE OF CHANGES IN THE MAST CELL COUNT IN THE SKIN AND THE TUNICA ADVENTITIA OF THE AORTIC WALL

1959 • 5 citations

Der Cholesterinspiegel im Plasma gesunder Menschen und seine Beeinflussung durch hohe Dosen L(+)-Ascorbinsäure

1973 • 5 citations

Die Wirkung der 1-Ascorbinsäure auf die Hypercholesterinaemie bei der experimentellen Cholestase und der Aminonucleosidnephrose

1975 • 5 citations

Dynamics of ascorbic acid stimulation of 26- 14 C cholesterol oxidation in guinea-pigs.

1972 • 5 citations

Biochemical changes in scorbutic rhesus monkeys.

1959 • 5 citations

Cholesterol turnover in guinea-pigs.

1973 • 5 citations

Actions of ascorbic acid on hormone induced lypolysis in vitro

1970 • 5 citations

Einige Aspekte der Wirkung hoher Dosen von <scp>L</scp>‐Ascorbinsäure auf den gesunden Menschen

1962 • 4 citations

SERUM-CHOLESTEROL AND WHOLE- BLOOD ASCORBIC ACID IN CHILDREN

1973 • 4 citations

The effect of simultaneous treatment with thyroxine and ascorbic acid precursors on serum cholesterol concentration

1972 • 4 citations

Redox State of Nicotinamide-Adenine Dinucleotide in the Inner and Outer Layers of Canine Left Ventricle, and Effects of Coronary Dilators on the Redox State

1974 • 4 citations

Sulfate Incorporation from Ascorbate 2-Sulfate into Chondroitin Sulfates by Embryonic Chick Cartilage Epiphyses

1974 • 4 citations

Metabolic studies on scorbutic guinea pigs

1964 • 3 citations

Fine structural effects of l-ascorbic acid on buccal epithelium

1974 • 3 citations

Certain aspects of carbohydrate & lipid metabolism in scorbutic rhesus monkeys.

1964 • 3 citations

Coronary lipohyalinosis

1974 • 3 citations

Effect of ascorbic acid sulfate on hyperlipemic rabbits

1974 • 2 citations

[ON ASCORBIC ACID TREATMENT OF PATIENTS WITH ATHEROSCLEROSIS].

1963 • 2 citations

Aortic Glycosaminoglycan of the Chronic Hypo vitamin C with or without Coconut Oil Administration-Report 3

1975 • 2 citations

Experimental Atherosclerosis with Chronic Covert Ascorbic Acid Deficiency

1975 • 2 citations

Stimulation of cholesterogenesis by ascorbic acid in adrenal of rats fed vitamin A.

1974 • 2 citations

Effect of duodenectomy on copper and iron metabolism.

1972 • 1 citations

Conversion of acetate to glycogen in scurvy

1964 • 1 citations