Pathobiochemical Changes of the Arterial Wall at the Inception of Atherosclerosis

Beyond Cholesterol

1989 • 6,533 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Pathologic Basis of Disease.

1980 • 4,790 citations

J. Submicrosc. Cytol. Pathol.

2000 • 2,783 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis

1991 • 1,703 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque.

1986 • 1,323 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.

1984 • 994 citations

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.

1990 • 930 citations

Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.

1991 • 879 citations

Immune Mechanisms in Atherosclerosis

2001 • 852 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Malondialdehyde-Altered Protein Occurs in Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

1988 • 757 citations

Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects.

1991 • 727 citations

Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis

1989 • 696 citations

Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.

1986 • 676 citations

Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions.

1991 • 669 citations

Albumin—An important extracellular antioxidant?

1988 • 643 citations

Pathologic Basis of Disease

1985 • 631 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins.

1979 • 545 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats.

1983 • 487 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.

1984 • 470 citations

The sequence of cell and matrix changes in atherosclerotic lesions of coronary arteries in the first forty years of life

1990 • 408 citations

In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells.

1983 • 396 citations

Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.

1985 • 388 citations

Induction and detection of a human endothelial activation antigen in vivo.

1986 • 378 citations

Enhanced macrophage uptake of low density lipoprotein after self-aggregation.

1988 • 371 citations

Visualization of the binding, endocytosis, and transcytosis of low-density lipoprotein in the arterial endothelium in situ.

1983 • 349 citations

Fatty streak initiation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits.

1987 • 337 citations

The pathogenesis of atherosclerosis: An overview

1991 • 306 citations

Physical-Chemical Basis of Lipid Deposition in Atherosclerosis

1974 • 290 citations

Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver cells

1991 • 275 citations

Initiation of atherosclerotic lesions in cholesterol-fed rabbits. I. Focal increases in arterial LDL concentration precede development of fatty streak lesions.

1989 • 272 citations

Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies.

1989 • 269 citations

Prelesional events in atherogenesis. Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit.

1986 • 267 citations

Atherosclerotic lesions in humans. In situ immunophenotypic analysis suggesting an immune mediated response.

1989 • 254 citations

Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein.

1985 • 249 citations

American Association of Pathologists president's address. New roles for the endothelium in inflammation and immunity.

1987 • 232 citations

Collagen characterisation and cell transformation in human atherosclerosis

1975 • 223 citations

Interstitial fluid lipoproteins.

1987 • 223 citations

The hyperlipidemic hamster as a model of experimental atherosclerosis

1987 • 222 citations

Cholestasis: Lamellar Structure of the Abnormal Human Serum Lipoprotein

1971 • 203 citations

Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation.

1989 • 200 citations

A reassessment of endothelial injury and arterial lesion formation.

1985 • 198 citations

Identification of Apo B-100 segments mediating the interaction of low density lipoproteins with arterial proteoglycans.

1988 • 196 citations

Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching.

1989 • 193 citations

Pathobiology of the Endothelial Cell

1982 • 190 citations

Collagen types in various layers of the human aorta and their changes with the atherosclerotic process

1986 • 189 citations

Advances in Veterinary Science and Comparative Medicine

1989 • 185 citations

Identification of macrophages and smooth muscle cells in human atherosclerosis using monoclonal antibodies

1985 • 183 citations

Immunohistochemical localization of the terminal C5b-9 complement complex in human aortic fibrous plaque

1985 • 183 citations

Lipid accumulation in rabbit aortic intima 2 hours after bolus infusion of low density lipoprotein. A deep-etch and immunolocalization study of ultrarapidly frozen tissue.

1991 • 177 citations

The distribution of labeled low-density lipoproteins across the rabbit thoracic aorta in vivo

1977 • 176 citations

Endothelial dysfunction and subendothelial monocyte macrophages in hypertension. Effect of angiotensin converting enzyme inhibition.

1991 • 173 citations

Atherogenesis during low level hypercholesterolemia in the nonhuman primate. I. Fatty streak formation.

1990 • 169 citations

Distribution of plasma proteins across the human aortic wall Barrier functions of endothelium and internal elastic lamina

1980 • 168 citations

Identification and distribution of fibrinogen, fibrin and fibrin (ogen) degradation products in atherosclerosis

1989 • 168 citations

Differential uptake of proteoglycan-selected subfractions of low density lipoprotein by human macrophages.

1990 • 162 citations

Prelesional complement activation in experimental atherosclerosis. Terminal C5b-9 complement deposition coincides with cholesterol accumulation in the aortic intima of hypercholesterolemic rabbits.

1989 • 158 citations

Lesion-derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophage degradation.

1991 • 158 citations

Recent advances in molecular pathology

1984 • 150 citations

Oxidative modification of beta-very low density lipoprotein. Potential role in monocyte recruitment and foam cell formation.

1989 • 148 citations

Influx in vivo of low density, intermediate density, and very low density lipoproteins into aortic intimas of genetically hyperlipidemic rabbits. Roles of plasma concentrations, extent of aortic lesion, and lipoprotein particle size as determinants.

1992 • 142 citations

Varying susceptibility of different low density lipoproteins to oxidative modification.

1991 • 140 citations

Animal models in atherosclerosis research

1985 • 136 citations

Isolation, purification, and characterization of a lipoprotein containing apo B from the human aorta

1982 • 135 citations

Measurement in vivo of irreversible degradation of low density lipoprotein in the rabbit aorta. Predominance of intimal degradation.

1984 • 129 citations

Atherogenesis: Initiating Factors

1973 • 126 citations

Immunohistochemical detection of macrophages and T lymphocytes in atherosclerotic lesions of cholesterol-fed rabbits.

1991 • 122 citations

Endothelial transport of macromolecules: transcytosis and endocytosis. A look from cell biology.

1991 • 122 citations

Endothelial Cell Biology in Health and Disease

1988 • 118 citations

The lipid-rich core region of human atherosclerotic fibrous plaques. Prevalence of small lipid droplets and vesicles by electron microscopy.

1989 • 117 citations

Oxidation of lipoproteins and atherosclerosis

1991 • 116 citations

INTERACTIONS OF PLASMA LIPOPROTEINS WITH ENDOTHELIAL CELLS*

1982 • 114 citations

Oxidized low‐density lipoprotein increases cultured human endothelial cell tissue factor activity and reduces protein C activation ¹

1991 • 113 citations

Endothelial cell activation induced by tumor necrosis factor and lymphotoxin.

1989 • 106 citations

Prevention of low density lipoprotein aggregation by high density lipoprotein or apolipoprotein A-I.

1990 • 101 citations

Characterization of two lipoproteins containing apolipoproteins B and E from lesion-free human aortic intima.

1988 • 100 citations

Role of the low density lipoprotein receptor in penetration of low density lipoprotein into rabbit aortic wall.

1985 • 100 citations

Prelesional events in atherogenesis

1987 • 98 citations

Ultrastructural discrimination of lipid droplets and vesicles in atherosclerosis: value of osmium-thiocarbohydrazide-osmium and tannic acid-paraphenylenediamine techniques.

1988 • 94 citations

ADVANCES IN VETERINARY SCIENCE AND COMPARATIVE MEDICINE, 1975

1977 • 93 citations

Role of dying endothelial cells in transendothelial macromolecular transport.

1990 • 93 citations

Studies on the Pathogenesis of Atherosclerosis [Abridged]

1969 • 91 citations

Warner-Lambert/Parke-Davis Award Lecture. Viral pathogenesis of atherosclerosis. Impact of molecular mimicry and viral genes.

1991 • 91 citations

Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions

1987 • 91 citations

Interaction of LDL with human arterial proteoglycans stimulates its uptake by human monocyte-derived macrophages.

1990 • 89 citations

Local variation in arterial wall permeability to low density lipoprotein in normal rabbit aorta.

1986 • 88 citations

A low density lipoprotein-sized particle isolated from human atherosclerotic lesions is internalized by macrophages via a non-scavenger-receptor mechanism.

1990 • 87 citations

Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit.

1986 • 85 citations

Endothelial Cell Dysfunctions

1992 • 84 citations

Interaction between elastin and elastases and its role in the aging of the arterial wall, skin and other connective tissues. A review

1984 • 83 citations

Isolation and and partial characterization of the lipid phases of human atherosclerotic plaques.

1980 • 83 citations

Receptors for modified low-density lipoproteins on human endothelial cells: different recognition for acetylated low-density lipoprotein and oxidized low-density lipoprotein

1991 • 81 citations

Lipoprotein-heparin-fibronectin-denatured collagen complexes enhance cholesteryl ester accumulation in macrophages.

1984 • 81 citations

Uptake, metabolism, and cytotoxicity of isomeric cholesterol-5,6-epoxides in rabbit aortic endothelial cells.

1991 • 81 citations

Lipoproteins Containing Apo B Extracted from Human Aortas Structure and Function^a

1985 • 80 citations

Hydrogen peroxide alters the physical state and function of the plasma membrane of pulmonary artery endothelial cells

1991 • 78 citations

Relationship of sulfated glycosaminoglycans and cholesterol content in normal and arteriosclerotic human aorta.

1989 • 78 citations

Quantitative ultrastructural analysis of perifibrous lipid and its association with elastin in nonatherosclerotic human aorta.

1985 • 77 citations

Localization of low-density lipoproteins in atherosclerotic lesions from human normolipemics employing a purified fluorescent-labeled antibody

1974 • 77 citations

Characterization of two unique cholesterol-rich lipid particles isolated from human atherosclerotic lesions.

1990 • 74 citations

In vivo catabolism of biologically modified LDL.

1984 • 74 citations

Immunoelectron-microscopic localization of the terminal C5b-9 complement complex in human atherosclerotic fibrous plaque

1986 • 70 citations

Development of accelerated atherosclerosis. Concepts derived from cell biology and animal model studies.

1983 • 70 citations

Lipoproteins in human atherosclerotic vessels

1979 • 69 citations

Pulmonary Endothelium in Health and Disease

1988 • 67 citations

Altered ultrastructural morphology of self-aggregated low density lipoproteins: coalescence of lipid domains forming droplets and vesicles.

1991 • 66 citations

Perturbation of cultured human endothelial cells by atherogenic levels of low density lipoprotein.

1988 • 66 citations

Modified plasma-derived lipoproteins in human atherosclerotic plaques

1988 • 65 citations

Modification of copper-catalyzed oxidation of low density lipoprotein by proteoglycans and glycosaminoglycans.

1991 • 65 citations

Alterations in human vascular endothelial cell function by oxygen free radicals. Platelet adherence and prostacyclin release.

1991 • 59 citations

Filipin-positive, oil red O-negative particles in atherosclerotic lesions induced by cholesterol feeding.

1984 • 59 citations

Increased 3H-thymidine incorporation into endothelial cells of swine fed cholesterol for 3 days

1969 • 58 citations

Interaction of native and cell-modified low density lipoprotein with collagen gel.

1988 • 57 citations

Some questions concerning a small, more electronegative LDL circulating in human plasma

1991 • 57 citations

Quantitative evaluation of the terminal C5b-9 complement complex by ELISA in human atherosclerotic arteries.

1987 • 57 citations

Atherosclerosis in nonhuman primates.

1977 • 55 citations

Specificity of the low density lipoprotein-glycosaminoglycan interaction.

1991 • 54 citations

Early endothelial changes in experimental primate atherosclerosis.

1979 • 54 citations

Cholesteryl ester efflux from extracellular and cellular elements of the arterial wall. Model systems in culture with cholesteryl linoleyl ether.

1986 • 54 citations

Sulfhydryl groups and peroxidase-like activity of albumin as scavenger of organic peroxides

1988 • 53 citations

Oxidized low density lipoprotein stimulates prostacyclin production by adult human vascular endothelial cells.

1988 • 53 citations

Atheroma formation: defective control in the intimal round-trip of cholesterol

1990 • 51 citations

Cellular events in the development of valvular atherosclerotic lesions induced by experimental hypercholesterolemia

1987 • 51 citations

Extracellular lipid deposition in atherosclerosis

1990 • 48 citations

Interaction of low density lipoproteins with human aortic elastin.

1991 • 47 citations

Intimal and medial plasma protein concentrations and endothelial function

1982 • 46 citations

Oxidants, ATP depletion, and endothelial permeability to macromolecules

1990 • 45 citations

Demonstration of fibronectin in normal and injured aorta by an indirect immunoperoxidase technique

1983 • 44 citations

Endothelial adaptations in aortic stenosis. Correlation with flow parameters.

1988 • 43 citations

Glycosaminoglycans and apolipoproteins B and A-I in human aortas. Chemical and immunological analysis of lesion-free aortas from children and adults.

1987 • 41 citations

In vivo transfer of cholesteryl ester from high and low density plasma lipoproteins into human aortic tissue.

1988 • 41 citations

Lysophosphatidylcholine stabilizes small unilamellar phosphatidylcholine vesicles. Phosphorus-31 NMR evidence for the "wedge" effect

1989 • 40 citations

Low-density lipoprotein binding affinity of arterial wall proteoglycans: characteristics of a chondroitin sulfate proteoglycan subfraction

1989 • 39 citations

Studies on fine structure and location of lipids in quick-freeze replicas of atherosclerotic aorta of WHHL rabbits

1987 • 39 citations

Mapping of proteoglycans in atherosclerotic lesions

1990 • 39 citations

Experimental obstructive coronary atherosclerosis in the hyperlipidemic hamster.

1990 • 38 citations

Endothelial Activation

1988 • 38 citations

Prelesional Modifications of the Vessel Wall in Hyperlipidemic Atherogenesis

1990 • 37 citations

Human aortic intima protein composition during initial stages of atherogenesis

1986 • 36 citations

Putative role of cholesteryl ester transfer protein in removal of cholesteryl ester from vascular interstitium, studied in a model system in cell culture

1985 • 36 citations

Lipoproteins as Carriers of Pharmacological Agents

2017 • 36 citations

Proteoglycans and Potential Mechanisms Related to Atherosclerosis^a

1985 • 35 citations

Lipid composition of aorta of Watanabe heritable hyperlipemic and comparably hypercholesterolemic fat-fed rabbits. Plasma lipid composition determines aortic lipid composition of hypercholesterolemic rabbits.

1988 • 33 citations

Lipid accumulation and ultrastructural change within the aortic wall during early spontaneous atherogenesis.

1980 • 33 citations

Atherosclerosis: New horizons

1985 • 32 citations

Bovine Pericardial Proteoglycan: Biochemical, Immunochemical and Ultrastructural Studies

1989 • 31 citations

The effect of saturated and polyunsaturated lecithins on the resorption of 4‐¹⁴C‐choles‐terol from subcutaneous implants

1967 • 31 citations

Mechanisms Involved in the Uptake and Degradation of Low Density Lipoprotein by the Artery Wall in Vivo^a

1985 • 31 citations

Effect of dietary cholesterol level on the composition of thoracic duct lymph lipoproteins isolated from nonhuman primates

1983 • 31 citations

Endothelial Dysfunction and Atherosclerosis

1989 • 30 citations

Structural and Functional Modifications of Human Aorta Proteoglycans in Atherosclerosis

1990 • 30 citations

Transport pathways of β-VLDL by aortic endothelium of normal and hypercholesterolemic rabbits

1989 • 29 citations

Pulmonary endothelium in health and disease

1987 • 29 citations

Endothelial proliferation and atherogenesis in rabbits with moderate hypercholesterolemia.

1980 • 28 citations

Macrophage uptake of low-density lipoprotein modified by 4-hydroxynonenal. An ultrastructural study.

1991 • 28 citations

Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A.

1988 • 27 citations

In vivo influx of free and esterified plasma cholesterol into human aortic tissue without atherosclerotic lesions.

1984 • 27 citations

Is the atherogenicity of Lp(a) caused by its reactivity with proteoglycans?

1990 • 26 citations

Interactions of endogenous lipoproteins with capillary endothelium in spontaneously hyperlipoproteinemic rats

1985 • 26 citations

Immunoelectron microscopic visualization of the transcytosis of low density lipoproteins in perfused rat arteries.

1989 • 26 citations

Relationship of Oxidant-mediated Cytotoxicity to Phospholipid Metabolism in Endothelial Cells

1991 • 25 citations

Purification and partial characterization of extracellular liposomes isolated from the hyperlipidemic rabbit aorta

1990 • 24 citations

Vascular Endothelium

1988 • 24 citations

Effect of nicardipine and verapamil on in vitro albumin transport in rabbit thoracic aorta.

1987 • 24 citations

Endothelial-Leukocyte Adhesion Molecules in Acute Inflammation and Atherogenesis

1992 • 23 citations

Lipoprotein-elastin interactions in human aorta fibrous plaque lesions

1981 • 23 citations

Albumin and Cr-EDTA uptake by systemic arteries, veins, and pulmonary artery of rabbit.

1990 • 23 citations

Modification of very low density lipoproteins leads to macrophage scavenger receptor uptake and cholesteryl ester deposition.

1987 • 23 citations

Studies on oxidized low density lipoproteins. Controlled oxidation and a prostaglandin artifact.

1989 • 22 citations

Cardiac and peripheral lymph lipoproteins in dogs fed cholesterol and saturated fat.

1984 • 22 citations

Lipoprotein composition and transport in the pig and dog cardiac lymphatic system.

1981 • 22 citations

Responses of Endothelial Cells to Injury

1982 • 22 citations

High concentrations of low density lipoprotein decrease basement membrane‐associated heparan sulfate proteoglycan in cultured endothelial cells

1990 • 21 citations

Interaction of lipoprotein(a) with fibronectin and its potential role in atherogenesis

1990 • 21 citations

Low-density lipoprotein transport in blood vessel walls of squirrel monkeys

1989 • 21 citations

Oxidized low density lipoprotein can reduce the pinocytic activity in cultured human endothelial cells as measured by cellular uptake of [14C]sucrose

1985 • 20 citations

Cytochemical localization of β-lipoproteins and their components in successive stages of hyperlipidemic atherogenesis of rabbit aorta

1989 • 20 citations

Evidence for the existence of non-esterified cholesterol carried by albumin in rat serum

1986 • 18 citations

Beta-VLDL increases endothelial cell plasma membrane cholesterol.

1991 • 18 citations

Atherosclerosis and molecular pathology: Mechanisms of cholesteryl ester accumulation in foam cells and extracellular space of atherosclerotic lesions.

1990 • 16 citations

Studies on the mechanism of uptake of low density lipoprotein-proteoglycan complex in macrophages

1991 • 16 citations

Prelesional Changes of Arterial Endothelium in Hyperlipoproteinemic Atherogenesis

1988 • 16 citations

Variability of the electrophoretic mobility of low density lipoprotein Comparison of interstitial fluid from human aortic intima and serum

1983 • 15 citations

Effect of nicardipine and verapamil on in vitro albumin transport in rabbit thoracic aorta.

1987 • 14 citations

Formation of factor Va by atherosclerotic rabbit aorta mediates factor Xa-catalyzed prothrombin activation.

1988 • 14 citations

Aortic endothelial cell damage induced by β-VLDL and macrophages in vitro

1990 • 13 citations

Prelesional events in atherogenesis. Changes induced by hypercholesterolemia in the cell surface chemistry of arterial endothelium and blood monocytes, in rabbit.

1987 • 13 citations

Aggregation of low density lipoproteins with unilamellar phosphatidylcholine vesicles

1982 • 12 citations

Endothelial Dysfunction and Atherosclerosis

1992 • 12 citations

Atherosclerotic involvement of coronary branch vessels

1986 • 11 citations

Demonstration of a keratan sulfate-containing proteoglycan in atherosclerotic aorta.

1992 • 11 citations

Endothelial Cell Response to Normal and Abnormal Stimuli

1992 • 10 citations

Distribution of endogenous albumin across the rat aortic wall as revealed by quantitative immunocytochemistry

1989 • 10 citations

Plasma macromolecules in interstitial fluid from normal and atherosclerotic human aorta.

1986 • 8 citations

Glomerular Dysfunction and Biopathology of Vascular Wall

1987 • 8 citations

Interactions of lipoproteins with vascular intima in atherosclerosis

1991 • 6 citations

Endothelial Cell Dysfunction and Injury in Experimental Hyperlipidemic Atherogenesis

1992 • 6 citations

Intimal Responses to Shear Stress, Hypercholesterolemia, and Hypertension

1988 • 5 citations

In vitro study of low density lipoprotein--collagen interaction.

1984 • 4 citations

Role of albumin for the cholesterol transport and on the steroidogenic pathways in serum-free medium newborn rat adrenocortical cell cultures

1986 • 4 citations

Deleted Work

1955 • 0 citations