Prelesional Changes of Arterial Endothelium in Hyperlipoproteinemic Atherogenesis

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

1981 • 1,325 citations

Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.

1984 • 994 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

1978 • 621 citations

Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans

1976 • 618 citations

Galloylglucoses of low molecular weight as mordant in electron microscopy. I. Procedure, and evidence for mordanting effect.

1976 • 598 citations

Lipoprotein oxidation and lipoprotein-induced cytotoxicity.

1983 • 545 citations

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

1985 • 500 citations

Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats.

1983 • 487 citations

Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.

1984 • 470 citations

Dietary induced atherogenesis in swine. Morphology of the intima in prelesion stages.

1979 • 393 citations

Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.

1985 • 388 citations

Visualization of the binding, endocytosis, and transcytosis of low-density lipoprotein in the arterial endothelium in situ.

1983 • 349 citations

Lipoproteins and atherosclerosis. A look back and a look ahead.

1983 • 315 citations

Altered Metabolism (In Vivo and In Vitro) of Plasma Lipoproteins after Selective Chemical Modification of Lysine Residues of the Apoproteins

1979 • 313 citations

Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes.

1982 • 296 citations

Immunocytochemical analysis of cellular components in atherosclerotic lesions. Use of monoclonal antibodies with the Watanabe and fat-fed rabbit.

1986 • 296 citations

Physical-Chemical Basis of Lipid Deposition in Atherosclerosis

1974 • 290 citations

Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species

1980 • 279 citations

Cellular aspects of transcapillary exchange

1983 • 277 citations

Prelesional events in atherogenesis. Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit.

1986 • 267 citations

Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein.

1985 • 249 citations

The hyperlipidemic hamster as a model of experimental atherosclerosis

1987 • 222 citations

Interactions of liposomes with the reticuloendothelial system

1982 • 213 citations

A reassessment of endothelial injury and arterial lesion formation.

1985 • 198 citations

Chemical composition and physical state of lipid deposits in atherosclerosis

1985 • 192 citations

Transfer of plasma lipoprotein components and of plasma proteins into aortas of cholesterol-fed rabbits. Molecular size as a determinant of plasma lipoprotein influx.

1981 • 182 citations

Extrahepatic synthesis of apolipoprotein E.

1984 • 177 citations

Distribution of plasma proteins across the human aortic wall Barrier functions of endothelium and internal elastic lamina

1980 • 168 citations

Control of monocyte recruitment by chemotactic factor(s) in lesion-prone areas of swine aorta.

1985 • 163 citations

Role of endothelial cells and their products in the modification of low-density lipoproteins

1986 • 159 citations

Role of macrophages in atherosclerosis. Sequential observations of cholesterol-induced rabbit aortic lesion by the immunoperoxidase technique using monoclonal antimacrophage antibody.

1985 • 157 citations

Foam cells in explants of atherosclerotic rabbit aortas have receptors for beta-very low density lipoproteins and modified low density lipoproteins.

1983 • 147 citations

Low density lipoproteins in atherosclerosis.

1988 • 144 citations

The effects of charge and size on the interaction of unilamellar liposomes with macrophages

1984 • 143 citations

Isolation, purification, and characterization of a lipoprotein containing apo B from the human aorta

1982 • 135 citations

Insoluble low-density lipoprotein-proteoglycan complexes enhance cholesteryl ester accumulation in macrophages.

1985 • 131 citations

Measurement in vivo of irreversible degradation of low density lipoprotein in the rabbit aorta. Predominance of intimal degradation.

1984 • 129 citations

Human monocyte adherence to cultured vascular endothelium: monoclonal antibody-defined mechanisms.

1985 • 127 citations

Lipids of human atherosclerotic plaques and xanthomas: clues to the mechanism of plaque progression.

1983 • 127 citations

Inhibition of receptor-mediated clearance of lysine and arginine modified lipoproteins from the plasma of rats and monkeys

1980 • 120 citations

Immunoreactive apolipoprotein E is a widely distributed cellular protein. Immunohistochemical localization of apolipoprotein E in baboon tissues.

1986 • 116 citations

Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. III. Intracellular localization of cholesterol and cholesteryl ester.

1979 • 115 citations

INTERACTIONS OF PLASMA LIPOPROTEINS WITH ENDOTHELIAL CELLS*

1982 • 114 citations

Endothelial surface characteristics in pigeon coronary artery atherosclerosis. I. Cellular alterations during the initial stages of dietary cholesterol challenge.

1982 • 114 citations

Ultrastructure of the human aortic fibrolipid lesion. Formation of the atherosclerotic lipid-rich core.

1986 • 111 citations

Cholesterol esterification in macrophages. Stimulation by lipoproteins containing apo B isolated from human aortas.

1984 • 107 citations

Early atherogenesis in White Carneau pigeons. II. Ultrastructural and cytochemical observations.

1985 • 104 citations

Stimulation of cholesteryl ester synthesis in macrophages by extracts of atherosclerotic human aortas and complexes of albumin/cholesteryl esters.

1981 • 103 citations

Role of the low density lipoprotein receptor in penetration of low density lipoprotein into rabbit aortic wall.

1985 • 100 citations

LDL, scavenger, and beta-VLDL receptors on aortic endothelial cells.

1984 • 98 citations

Prelesional events in atherogenesis

1987 • 98 citations

The origin and properties of free cholesterol potential gradients in plasma, and their relation to atherogenesis

1984 • 91 citations

Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions

1987 • 91 citations

Studies on the Pathogenesis of Atherosclerosis [Abridged]

1969 • 91 citations

Localization patterns of plasma apolipoproteins in human atherosclerotic lesions.

1975 • 90 citations

Early atherogenesis in White Carneau pigeons. I. Leukocyte margination and endothelial alterations at the celiac bifurcation.

1984 • 90 citations

Human arterial wall cells secrete factors that are chemotactic for monocytes.

1983 • 88 citations

Local variation in arterial wall permeability to low density lipoprotein in normal rabbit aorta.

1986 • 88 citations

Effect of contact inhibition on the regulation of cholesterol metabolism in cultured vascular endothelial cells.

1979 • 88 citations

LDL Heterogeneity and Atherosclerosis in Nonhuman Primates^a

1985 • 84 citations

Lipoprotein-heparin-fibronectin-denatured collagen complexes enhance cholesteryl ester accumulation in macrophages.

1984 • 81 citations

Lipoproteins Containing Apo B Extracted from Human Aortas Structure and Function^a

1985 • 80 citations

Apoprotein E is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or bacillus Calmette-Guerin-activated macrophages.

1983 • 80 citations

Quantitative ultrastructural analysis of perifibrous lipid and its association with elastin in nonatherosclerotic human aorta.

1985 • 77 citations

Effect of human plasma lipoproteins on prostacyclin production by cultured endothelial cells.

1985 • 75 citations

Aortic intimal monocyte recruitment in the normo and hypercholesterolemic baboon (Papio cynocephalus)

1985 • 74 citations

Exposure to fatty acid increases human low density lipoprotein transfer across cultured endothelial monolayers.

1985 • 73 citations

Development of accelerated atherosclerosis. Concepts derived from cell biology and animal model studies.

1983 • 70 citations

Low-density lipoprotein concentration in interstitial fluid from human atherosclerotic lesions

1983 • 70 citations

Role of apolipoproteins in cellular cholesterol efflux

1986 • 67 citations

Effect of monocyte migration on low density lipoprotein transport across aortic endothelial cell monolayers.

1984 • 65 citations

Effects of moderate hypercholesterolemia on rabbit endothelium.

1981 • 64 citations

A proposed structure of chondroitin 6-sulfate proteoglycan of human normal and adjacent atherosclerotic plaque.

1986 • 63 citations

Plasma low density lipoprotein accumulation in aortas of hypercholesterolemic swine correlates with modifications in aortic glycosaminoglycan composition

1986 • 62 citations

Plasma protein concentrations in interstitial fluid from human aortas

1982 • 59 citations

Filipin-positive, oil red O-negative particles in atherosclerotic lesions induced by cholesterol feeding.

1984 • 59 citations

Proteoglycan Structure and Function as Related to Atherosclerosis^a

1985 • 58 citations

Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance.

1986 • 58 citations

Flux of plasma lipoproteins into human arterial intima Comparison between grossly normal and atheromatous intima

1981 • 57 citations

Human aortic fibrolipid lesions. Progenitor lesions for fibrous plaques, exhibiting early formation of the cholesterol-rich core.

1985 • 56 citations

Cholesteryl ester efflux from extracellular and cellular elements of the arterial wall. Model systems in culture with cholesteryl linoleyl ether.

1986 • 54 citations

Histochemical detection of esterified cholesterol within human atherosclerotic lesions using the fluorescent probe filipin

1984 • 54 citations

Early endothelial changes in experimental primate atherosclerosis.

1979 • 54 citations

Differences in the uptake of modified low density lipoproteins by tissue cultured endothelial cells

1985 • 52 citations

Cellular events in the development of valvular atherosclerotic lesions induced by experimental hypercholesterolemia

1987 • 51 citations

Increased synthesis of aortic collagen and elastin in experimental atherosclerosis

1981 • 50 citations

Histochemical detection and differentiation of free and esterified cholesterol in swine atherosclerosis using filipin

1984 • 50 citations

On the presence of a Concanavalin-A reactive coat over the endothelial aortic surface and its modifications during early experimental cholesterol atherogenesis in rabbits

1973 • 49 citations

Properties of lipoprotein complexes isolated by affinity chromatography from human aorta.

1985 • 48 citations

Endothelial cell proliferation and monocyte adhesion to atherosclerotic lesions of white carneau pigeons.

1986 • 48 citations

Aortic accumulation and plasma clearance of beta-VLDL and HDL: effects of diet-induced hypercholesterolemia in rabbits.

1985 • 42 citations

Receptor-Mediated Transcytosis of Plasma Molecules by Vascular Endothelium

1988 • 40 citations

Transcellular transport of lipoprotein through arterial endothelial cells in monolayer culture.

1986 • 40 citations

Uptake and degradation of low density lipoproteins (LDL) by confluent, contact-inhibited bovine and human endothelial cells exposed to physiological concentrations of LDL

1979 • 39 citations

Elastin—lipid interaction in the arterial wall part 2. In vitro binding of lipoprotein-lipids to arterial elastin and the inhibitory effect of high density lipoproteins on the process

1981 • 38 citations

Evidence for the presence of tissue-free cholesterol in low density and high density lipoproteins of human peripheral lymph

1980 • 37 citations

Increased uptake of circulating low-density lipoproteins and fibrinogen by arterial walls after removal of sialic acids from their endothelial surface.

1982 • 36 citations

Phospholipid liposomes acquire apolipoprotein E in atherogenic plasma and block cholesterol loading of cultured macrophages.

1987 • 35 citations

Relationship of plasma lipoproteins and the monocyte-macrophage system to atherosclerosis severity in cholesterol-fed pigeons.

1986 • 34 citations

Dynamics of lipoprotein-glycosaminoglycan interactions in the atherosclerotic rabbit aorta in vivo

1984 • 33 citations

Atherosclerosis: New horizons

1985 • 32 citations

Surface determinants of low density lipoprotein uptake by endothelial cells

1984 • 31 citations

Mechanisms Involved in the Uptake and Degradation of Low Density Lipoprotein by the Artery Wall in Vivo^a

1985 • 31 citations

Receptor-mediated catabolism and tissue uptake of human low density lipoprotein in the cholesterol-fed, atherosclerotic rabbit

1982 • 31 citations

Ultrastructural localization of plasma lipoproteins in human intracranial arteries

1975 • 31 citations

Elastin-lipid interaction action in the arterial wall

1979 • 29 citations

In vivo influx of free and esterified plasma cholesterol into human aortic tissue without atherosclerotic lesions.

1984 • 27 citations

Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A.

1988 • 27 citations

Visualization of binding and receptor-mediated uptake of low density lipoproteins by human endothelial cells.

1985 • 27 citations

Ultrastructural localization of apolipoprotein B in human aortic and coronary atherosclerotic plaques

1977 • 26 citations

Interactions of endogenous lipoproteins with capillary endothelium in spontaneously hyperlipoproteinemic rats

1985 • 26 citations

Metabolism of low density lipoprotein by bovine endothelial cells as a function of cell density.

1984 • 24 citations

Lipoprotein-elastin interactions in human aorta fibrous plaque lesions

1981 • 23 citations

Quantification and immunolocalization of apolipoprotein E in experimental atherosclerosis

1986 • 22 citations

Studies on the passage of plasma proteins across arterial endothelium in relation to atherogenesis.

1977 • 21 citations

Oxidized low density lipoprotein can reduce the pinocytic activity in cultured human endothelial cells as measured by cellular uptake of [14C]sucrose

1985 • 20 citations

Atherosclerotic lesions in coronary arteries of hyperlipidemic swine

1986 • 19 citations

Permeation and deposition of fibrinogen and low-density lipoprotein in the aorta and cerebral artery of rabbits--immuno-electron microscopic study.

1984 • 19 citations

Evidence for the existence of non-esterified cholesterol carried by albumin in rat serum

1986 • 18 citations

Enzymology of long-chain base synthesis by aorta: induction of serine palmitoyltransferase activity in rabbit aorta during atherogenesis.

1988 • 18 citations

Glomerular dysfunction and biopathology of vascular wall

1985 • 18 citations

Immunohistochemical localization of apolipoprotein E in atherosclerotic lesions of the aorta and coronary arteries

1986 • 15 citations

Intimal cell mass-derived atherosclerotic lesions in the abdominal aorta of hyperlipidemic swine

1986 • 15 citations

Native and acetylated low density lipoprotein metabolism in proliferating and quiescent bovine endothelial cells in culture.

1985 • 15 citations

Arterial prostaglandins and lysosomal function during atherogenesis

1985 • 15 citations

Possible relationship of cholesterol accumulation and collagen synthesis in rabbit aortic tissues

1980 • 15 citations

Prelesional events in atherogenesis. Changes induced by hypercholesterolemia in the cell surface chemistry of arterial endothelium and blood monocytes, in rabbit.

1987 • 13 citations

The in vivo transfer of free and esterified cholesterol from plasma into the arterial wall of hypercholesterolemic rabbits

1982 • 12 citations

Lipid transport between blood and tissue cells by lateral movement in a continuum of cell membranes

1980 • 11 citations

Proliferation, morphology, and low-density lipoprotein metabolism of arterial endothelial cells cultured from normal and diabetic minipigs

1985 • 8 citations

Effect of high density lipoproteins on permeability of rabbit aorta to low density lipoproteins

1985 • 8 citations

Cell surface chemistry of arterial endothelium and blood monocytes in the normolipidemic rabbit.

1987 • 7 citations

Very low density lipoprotein binding to cultured aortic endothelium

1985 • 7 citations

In vitro study of low density lipoprotein--collagen interaction.

1984 • 4 citations

Spatial distribution and accumulation of low density lipoproteins in the abdominal aorta of swine: determination by a novel electrotransfer procedure.

1986 • 3 citations

The permeability of aortic endothelium to 125I-BSA in hyperlipidemic hamster. Effect of histamine and serotonin.

1986 • 2 citations

Apolipoprotein B: removal of lipids by sodium cholate and reassociation of a lipid-free apoprotein with dipalmitoyl phosphatidylcholine.

1984 • 1 citations