Multiple kinases and signal transduction. Phosphorylation of the T cell antigen receptor complex.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1981 • 492 citations

ADENYLATE CYCLASE-COUPLED BETA-ADRENERGIC RECEPTORS: Structure and Mechanisms of Activation and Desensitization

1983 • 486 citations

Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells

1981 • 426 citations

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor

1986 • 387 citations

Identification of the components of the murine T cell antigen receptor complex

1985 • 333 citations

Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.

1984 • 331 citations

Epidermal growth factor-dependent phosphorylation of lipocortin

1986 • 303 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

Amino-terminal sequence of p36 and associated p10: identification of the site of tyrosine phosphorylation and homology with S-100.

1985 • 268 citations

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

1982 • 252 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

Mitogens increase phosphorylation of phosphoinositides in thymocytes

1984 • 223 citations

A T3-like protein complex associated with the antigen receptor on murine T cells

1986 • 213 citations

Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten

1981 • 203 citations

Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor.

1986 • 182 citations

Binding of phorbol esters to high‐affinity sites on murine fibroblastic cells elicits a mitogenic response

1982 • 167 citations

Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein.

1985 • 163 citations

Phosphatidylinositol-specific phospholipase-C of platelets: Association with 1,2-diacylglycerol-kinase and inhibition by cyclic-AMP

1979 • 161 citations

Homologous and heterologous mitogenic desensitization of Swiss 3T3 cells to phorbol esters and vasopressin: Role of receptor and postreceptor steps

1984 • 154 citations

Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor

1979 • 154 citations

Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes.

1984 • 153 citations

Characterization of phorbol ester receptors and their down-modulation in GH4C1 rat pituitary cells.

1981 • 142 citations

Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures.

1983 • 133 citations

Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.

1985 • 131 citations

Counteraction of Calcium-Activated, Phospholipid-Dependent Protein Kinase Activation by Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′-Monophosphate in Platelets1

1982 • 110 citations

Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes.

1984 • 107 citations

A 20-kDa protein associated with the murine T-cell antigen receptor is phosphorylated in response to activation by antigen or concanavalin A.

1985 • 93 citations

Synergistic stimulation of DNA synthesis by cyclic AMP derivatives and growth factors in mouse 3T3 cells

1982 • 78 citations

Anti-immunoglobulin and phorbol ester induce phosphorylation of proteins associated with the plasma membrane and cytoskeleton in murine B lymphocytes.

1986 • 67 citations

Characterization of an anti-peptide antibody that recognizes the murine analogue of the human T cell antigen receptor-T3 delta-chain.

1986 • 58 citations

Tumor promoters cause changes in the state of phosphorylation and apparent molecular weight of a tyrosine protein kinase in T lymphocytes.

1986 • 56 citations

Modulation of plasminogen activator synthesis in chick embryo fibroblasts by cyclic nucleotides and phorobol myristate acetate.

1979 • 56 citations

Cyclic AMP treatment of Rous sarcoma virus-transformed Chinese hamster ovary cells increases phosphorylation of pp60src and increases pp60src kinase activity.

1983 • 45 citations

ROLE OF CYCLIC NUCLEOTIDES IN REGULATING LYMPHOCYTES

1979 • 38 citations

Interactions between cyclic AMP‐ and phorbol ester‐dependent phosphorylation systems in S49 mouse lymphoma cells

1985 • 25 citations

An analysis of the structure of the antigen receptor on a pigeon cytochrome c-specific T cell hybrid.

1985 • 24 citations