α-Thalassemia resulting from a negative chromosomal position effect

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

Chromatin Structure and Function

1979 • 1,050 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

The Thalassæmia Syndromes.

1973 • 820 citations

Tsix, a gene antisense to Xist at the X-inactivation centre

1999 • 809 citations

CpG methylation, chromatin structure and gene silencing---a three-way connection

1998 • 791 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

HETEROCHROMATIN AND GENE EXPRESSION IN DROSOPHILA

1995 • 526 citations

The Sins of the Fathers and Mothers

1999 • 489 citations

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

1990 • 477 citations

The Thalassaemia Syndromes

1982 • 446 citations

A review of the molecular genetics of the human alpha-globin gene cluster

1989 • 443 citations

A review of the molecular genetics of the human alpha-globin gene cluster

1989 • 427 citations

Position effects and epigenetic silencing of plant transgenes

1998 • 402 citations

Cytosine methylation and mammalian development

1999 • 384 citations

Position effect in human genetic disease

1998 • 374 citations

Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation

1996 • 373 citations

DNA methylation directs a time-dependent repression of transcription initiation

1997 • 372 citations

Recombination at the human α-globin gene cluster: Sequence features and topological constraints

1987 • 345 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription

1996 • 328 citations

Delineation of DNA replication time zones by fluorescence in situ hybridization.

1992 • 305 citations

Role of replication time in the control of tissue-specific gene expression.

1987 • 249 citations

LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids

1999 • 229 citations

Cosmid vectors for rapid genomic walking, restriction mapping, and gene transfer.

1987 • 222 citations

Beyond the Nucleosome: Epigenetic Aspects of Position–Effect Variegation in Drosophila

1998 • 221 citations

Transcriptional enhancers act in cis to suppress position-effect variegation.

1996 • 187 citations

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.

1995 • 187 citations

Genes and genomes: Chromosome bands – flavours to savour

1993 • 182 citations

Chromatin structure and function

1994 • 180 citations

Baillière's clinical haematology

1998 • 168 citations

Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin

1992 • 162 citations

The relationship between chromosome structure and function at a human telomeric region

1997 • 149 citations

The molecular basis of alpha-thalassaemia in Thailand.

1984 • 141 citations

Mechanisms of silencing in Saccharomyces cerevisiae

1998 • 133 citations

The role of heterochromatin in the expression of a heterochromatic gene, the rolled locus of Drosophila melanogaster.

1993 • 127 citations

The organization and expression of the light gene, a heterochromatic gene of Drosophila melanogaster.

1990 • 124 citations

Dividing the empire: boundary chromatin elements delimit the territory of enhancers

1999 • 103 citations

Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.

1995 • 95 citations

The Pattern of Replication at a Human Telomeric Region (16p13.3): Its Relationship to Chromosome Structure and Gene Expression

1999 • 83 citations

Understanding alpha globin gene expression: a step towards effective gene therapy.

1998 • 82 citations

An uncertain silence

1997 • 65 citations

Alpha zero-thalassemia due to recombination between the alpha 1-globin gene and an AluI repeat

1985 • 65 citations

Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere.

1993 • 61 citations

Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element.

1995 • 52 citations

Targeted inactivation of the major positive regulatory element (HS-40) of the human alpha-globin gene locus

1995 • 49 citations

Variegated Expression of a Globin Transgene Correlates with Chromatin Accessibility But Not Methylation Status

1996 • 49 citations

Analysis of a 70 kb segment of DNA containing the human ζ and α-globin genes linked to their regulatory element (HS-40) in transgenic mice

1994 • 45 citations

Position effects in mice carrying a lacZ transgene in cis with the -globin LCR can be explained by a graded model

1997 • 38 citations

A rosy future for heterochromatin.

1994 • 29 citations

Genomic position effects lead to an inefficient reorganization of nucleosomes in the 5'-regulatory region of the chicken lysozyme locus in transgenic mice

1996 • 27 citations

A new α‐thalassemia‐2 deletion resulting in microcytosis and hypochromia and in vitro chain imbalance in the heterozygote

1993 • 16 citations