Extracellular matrix metalloproteinases in tumor invasion and metastasis

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

1977 • 1,422 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells

1980 • 1,094 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Tumor heterogeneity and the biology of cancer invasion and metastasis.

1978 • 833 citations

The Biology of Cancer Invasion and Metastasis

1978 • 819 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Cellular Biology and Biochemistry of the Retinoids

1984 • 730 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

BIOCHEMICAL INTERACTIONS OF TUMOR CELLS WITH THE BASEMENT MEMBRANE

1986 • 693 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Fos-Associated Protein p39 Is the Product of the jun Proto-Oncogene

1988 • 643 citations

Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.

1986 • 632 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Cancer metastasis

1982 • 567 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

1979 • 452 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

Interleukin 1 stimulation of collagenase production by cultured fibroblasts.

1983 • 373 citations

The collagen substrate specificity of human skin fibroblast collagenase.

1981 • 371 citations

The collagenase gene family in humans consists of at least four members

1988 • 364 citations

Retinoids as preventive and therapeutic anticancer agents (Part I).

1987 • 361 citations

Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells

1988 • 352 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.

1985 • 344 citations

Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.

1986 • 339 citations

Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants.

1989 • 329 citations

Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.

1987 • 323 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

The role of proteinase in cellular invasiveness

1983 • 297 citations

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

1986 • 260 citations

NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice.

1985 • 240 citations

Human skin fibroblast collagenase inhibitor. Comparative studies in human connective tissues, serum, and amniotic fluid.

1983 • 231 citations

The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin.

1988 • 227 citations

Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

1987 • 226 citations

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells.

1988 • 223 citations

Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components

1983 • 222 citations

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

1986 • 215 citations

Laminin increases the release of type IV collagenase from malignant cells.

1986 • 188 citations

Laminin molecular domains which alter metastasis in a murine model.

1984 • 187 citations

Collagenolytic enzymes in human neoplasms.

1972 • 177 citations

Immunocytochemical localization of urokinase-type plasminogen activator in Lewis lung carcinoma.

1984 • 173 citations

The activation of human skin fibroblast procollagenase. Sequence identification of the major conversion products.

1987 • 173 citations

Purification and properties of a gelatin-specific neutral protease from human skin.

1981 • 169 citations

Purification and characterization of a collagenase extracted from rabbit tumours

1975 • 169 citations

Human Skin Fibroblast Collagenase: Interaction with Substrate and Inhibitor

1985 • 167 citations

QUANTITATION AND IMMUNOCYTOCHEMICAL LOCALIZATION OF HUMAN SKIN COLLAGENASE IN BASAL CELL CARCINOMA

1977 • 166 citations

Inhibition by Retinoic Acid of Collagenase Production in Rheumatoid Synovial Cells

1980 • 164 citations

Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells.

1989 • 163 citations

A specific inhibitor of vertebrate collagenase produced by human skin fibroblasts.

1979 • 157 citations

Monoclonal antibody preparation and purification of a tumor cell collagenase-stimulatory factor.

1989 • 155 citations

Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin

1989 • 151 citations

Inhibition by retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells.

1989 • 151 citations

Rat mammary carcinoma cells secrete active collagenase and activate latent enzyme in the stroma via plasminogen activator

1981 • 149 citations

Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts.

1987 • 146 citations

Expression of Collagenase IV (Basement Membrane Collagenase) Activity in Murine Tumor Cell Hybrids That Differ in Metastatic Potential<xref ref-type="fn" rid="FN2">2</xref>

1985 • 145 citations

Effect of Natural Protease Inhibitors and a Chemoattractant on Tumor Cell Invasion In Vitro

1982 • 141 citations

Collagenase production by synovial fibroblasts treated with phorbol myristate acetate

1979 • 139 citations

Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes.

1987 • 129 citations

Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene

1987 • 127 citations

Human fibroblast collagenase: glycosylation and tissue-specific levels of enzyme synthesis.

1986 • 125 citations

Cell detachment and metastasis

1983 • 123 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.

1990 • 119 citations

Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression

1988 • 112 citations

Transcriptional regulation of human stromelysin

1989 • 109 citations

Invasive and Metastatic Potential of a v-Ha-ras-Transformed Human Bronchial Epithelial Cell Line

1989 • 103 citations

Increases in levels of procollagenase messenger RNA in cultured fibroblasts induced by human recombinant interleukin 1 beta or serum follow c-jun expression and are dependent on new protein synthesis.

1989 • 97 citations

Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases

1989 • 97 citations

Enhanced collagenase production by fibroblasts derived from human basal cell carcinomas.

1979 • 95 citations

Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells.

1989 • 95 citations

Collagenase stimulation in cocultures of human fibroblasts and human tumor cells

1984 • 95 citations

Effect of collagenolytic activity in basal cell epithelioma of the skin on reconstituted collagen and physical properties and kinetics of the crude enzyme.

1972 • 91 citations

Retinoic Acid Inhibition of Collagenase and Gelatinase Expression in Human Skin Fibroblast Cultures. Evidence for a Dual Mechanism

1983 • 88 citations

Inhibition of collagen degradative enzymes by retinoic acid in vitro

1982 • 82 citations

Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1β or phorbol ester

1987 • 81 citations

Rabbit bone collagenase inhibitor blocks the activity of other neutral metalloproteinases

1979 • 80 citations

Collagenolytic activity in malignant melanoma: physiocochemical studies.

1973 • 75 citations

Stimulation of Skin Fibroblast Collagenase Production by a Cytokine Derived from Basal Cell Carcinomas

1985 • 74 citations

Modulation by retinoic acid and corticosteroids of collagenase production by rabbit synovial fibroblasts treated with phorbol myristate acetate or poly(ethylene glycol)

1981 • 73 citations

Collagenase Activity in Epidermoid Carcinoma of the Oral Cavity and Larynx

1975 • 71 citations

Enrichment of collagen and gelatin degrading activities in the plasma membranes of human cancer cells.

1987 • 60 citations

Type V Collagen

1987 • 60 citations

Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin

1988 • 60 citations

Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene

1988 • 59 citations

Establishment of Basal Cell Carcinoma in Culture: Evidence for a Basal Cell Carcinoma-Derived Factor(s) Which Stimulates Fibroblasts to Proliferative and Release Collagenase

1985 • 57 citations

Monoclonal antibodies to type IV collagenase recognize a protein with limited sequence homology to interstitial collagenase and stromelysin

1988 • 51 citations

Metastatic mouse melanoma cells release collagen-gelatin degrading metalloproteinases as components of shed membrane vesicles

1987 • 51 citations

Collagenolytic activity of rabbit V2-carcinoma growing at multiple sites

1978 • 44 citations

Collagenase activity in rabbit carcinoma: Cell source and cell interactions

1983 • 42 citations

Proteolytic Enzymes in Tumor Metastasis. II. Collagenase Type IV Activity in Subcellular Fractions of Cloned Tumor Cell Populations<xref ref-type="fn" rid="FN2">2</xref>

1985 • 41 citations

Tumor promoters induce a transient expression of tumor-associated genes in both basal and differentiated cells of the mouse epidermis

1988 • 41 citations

Extractable Collagenase and Carcino Genesis of the Mouse Skin

1977 • 35 citations

Type VII Collagen

1987 • 35 citations

Matrix influence on the tumor cell stimulation of fibroblast collagenase production

1985 • 29 citations

Evidence for a latent form a collagenase extracted from rabbit tumour cells

1977 • 25 citations

Purification of gelatin-specific neutral protease from human skin by conventional and high-performance liquid chromatography

1985 • 21 citations

Collagenase in Human Head and Neck Tumors and Rat Tumors and Fibroblasts in Monolayer Cultures

1986 • 21 citations

Type IV collagenase activity of a primary HSV-2-induced hamster fibrosarcoma and itsin vivo metastases andin vitro clones

1987 • 13 citations

Modulation of type IV collagenase and plasminogen activator in a hamster fibrosarcoma by basement membrane components and lung fibroblasts

1988 • 7 citations

Keratinocyte‐ and Tumor‐Derived Inducers of Collagenase^a

1988 • 4 citations