A Proposed Pharmacological Role for Dihydropyridine Binding Sites in Heart and Coronary Smooth Muscle

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

1984 • 1,292 citations

Ionic channels of excitable membranes

1985 • 1,185 citations

Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency

1978 • 1,103 citations

Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels

1983 • 1,010 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

1983 • 869 citations

Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.

1984 • 553 citations

Calcium in biological systems

1976 • 550 citations

Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs

1984 • 544 citations

The classification of drugs and drug receptors in isolated tissues.

1984 • 474 citations

[41] LIGAND: A computerized analysis of ligand binding data

1983 • 324 citations

Calcium channels: direct identification with radioligand binding studies

1982 • 302 citations

Characterization of binding of the Ca++ channel antagonist, [3H]nitrendipine, to guinea-pig ileal smooth muscle.

1983 • 292 citations

Statistics for the Biological Sciences

1969 • 269 citations

The agonist effect of dihydropyridines on Ca channels

1984 • 264 citations

The binding of [3H]nitrendipine to receptors for calcium channel antagonists in the heart, cerebral cortex, and ileum of rats

1982 • 227 citations

Sites of action of Ca2+ channel inhibitors

1983 • 224 citations

Methods in Pharmacology

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A unitary mechanism of calcium antagonist drug action.

1983 • 214 citations

Calcium antagonists receptor sites labeled with [3H]nitrendipine

1982 • 193 citations

Modern methods in pharmacology

1982 • 191 citations

The interaction of [3H]nitrendipine with receptors for calcium antagonists in the cerebral cortex and heart of rats

1982 • 186 citations

1,4‐Dihydropyridine Ca²⁺ channel antagonists and activators: A comparison of binding characteristics with pharmacology

1984 • 182 citations

Antiarrhythmic drug action. Blockade of the inward sodium current.

1984 • 163 citations

Cellular Action of Calcium Channel Blocking Drugs

1984 • 159 citations

Specific binding of [3H]nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem

1982 • 158 citations

Statistics for the Biological Sciences

1979 • 155 citations

Evidence for multiple receptor sites within the putative calcium channel

1982 • 134 citations

[3H]-Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes.

1981 • 129 citations

Calcium Channel Modulation

1984 • 128 citations

Molecular Pharmacology of the Calcium Channel

1984 • 122 citations

Activation of calcium channels by novel 1,4-dihydropyridines. A new mechanism for positive inotropics or smooth muscle stimulants.

1983 • 118 citations

SIMULTANEOUS ASSESSMENT OF EFFECTS OF CORONARY VASODILATORS ON THE CORONARY BLOOD FLOW AND THE MYOCARDIAL CONTRACTILITY BY USING THE BLOOD-PERFUSED CANINE PAPILLARY MUSCLE

1976 • 113 citations

Regulation of cardiac calcium channel current and contractile activity by the dihydropyridine bay K8644 is voltage-dependent

1984 • 97 citations

Diltiazem enhancement of [3H]nitrendipine binding to calcium channel associated drug receptor sites in rat brain synaptosomes

1982 • 97 citations

Specific binding of a calcium channel activator, [3H]BAY k 8644, to membranes from cardiac muscle and brain

1984 • 90 citations

Characteristics of the binding of [3H]nitrendipine to rabbit ventricular membranes: modification by other Ca++ channel antagonists and by the Ca++ channel agonist Bay K 8644.

1984 • 87 citations

Isolation of sealed vesicles highly enriched with sarcolemma markers from canine ventricle

1980 • 78 citations

Chronotropic, inotropic, and vasodilator actions of diltiazem, nifedipine, and verapamil. A comparative study of physiological responses and membrane receptor activity.

1983 • 74 citations

Enhancement of calcium influx in human platelets by CGP 28392, a novel dihydropyridine

1984 • 65 citations

Multi-subsite receptors for multivalent ligands. Application to drugs, hormones, and neurotransmitters.

1979 • 63 citations

Prolongation of calcium channel open time by the dihydropyridine derivative BAY K 8644 in cardiac myocytes.

1984 • 58 citations

Binding of the calcium channel blocker nitrendipine to its receptor in purified sarcolemma from canine cardiac ventricle

1983 • 57 citations

Binding properties of a novel calcium channel activating dihydropyridine in monolayer cultures of beating myocytes

1984 • 57 citations

Relationship of binding of a calcium channel blocker to inhibition of contraction in intact cultured embryonic chick ventricular cells.

1983 • 56 citations

Differential labelling of putative skeletal muscle calcium channels by [3H]-nifedipine, [3H]-nitrendipine, [3H]-nimodipine and [3H]-PN 200 110

1983 • 54 citations

Effects of dihydropyridine calcium channel modulators in the heart: Pharmacological and radioligand binding correlations

1984 • 53 citations

Diltiazem potentiates the negative inotropic action of nimodipine in heart

1983 • 48 citations

Effects of a Novel Calcium Channel Agonist Dihydropyridine Analogue, Bay k 8644, on Pig Coronary Artery

1985 • 48 citations

Vasodilator and hypotensive effects of the optical isomers of nicardipine (YC-93),a new Ca2+-antagonist.

1982 • 45 citations

Recent advances in the pharmacology of the calcium channel

1984 • 43 citations

LOCAL ANESTHETIC ACTION ON INACTIVATION OF THE Na CHANNEL IN NERVE AND SKELETAL MUSCLE: POSSIBLE MECHANISMS FOR ANTIARRHYTHMIC AGENTS

1978 • 43 citations

Current awareness series

1984 • 41 citations

[3H]nitrendipine labelling of the Ca2+ channel in skeletal muscle

1982 • 41 citations

Tissue response selectivity of calcium antagonists is not due to heterogeneity of [³H]‐nitrendipine binding sites

1984 • 39 citations

Molecular pharmacology of the calcium channel

1984 • 38 citations

Effects of Bay k 8644, a dihydropyridine analog, on [3H]nitrendipine binding to canine cardiac sarcolemma and the relationship to a positive inotropic effect.

1984 • 37 citations

[3H]Nimodipine specific binding to cardiac myocytes and subcellular fractions

1983 • 36 citations

Calcium in biological systems

1983 • 35 citations

Isolated Heart Preparations Perfused or Superfused with Balanced Salt Solutions

1984 • 32 citations

Correlation of nitrendipine and bay k 8644 binding to isolated canine heart sarcolemma with their pharmacological effects on the canine heart

1984 • 28 citations

Dual Effects of a New Coronary Vasodilator, Diltiazem, on the Contractile Force of the Blood-Perfused Papillary Muscle Of The Dog

1975 • 27 citations

Molecular Approach to the Calcium Channel

1985 • 24 citations

CGP 28392, a Dihydropyridine Ca2+ Entry Stimulator

1985 • 10 citations

Inotropic effects of Nifedipine: a new coronary dilating agent.

1974 • 10 citations

Voltage clamp comparison of the organic calcium channel blockers D-600 and nisoldipine.

1984 • 4 citations