Tissue response selectivity of calcium antagonists is not due to heterogeneity of [3H]‐nitrendipine binding sites

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1982 • 2,259 citations

Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels

1983 • 1,010 citations

Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem

1980 • 865 citations

Mlab — A mathematical modeling tool

1979 • 391 citations

THE PHARMACOLOGICAL DIFFERENTIATION OF ADRENERGIC RECEPTORS*

1967 • 376 citations

[3H]nitrendipine-labeled calcium channels discriminate inorganic calcium agonists and antagonists.

1982 • 265 citations

The binding of [3H]nitrendipine to receptors for calcium channel antagonists in the heart, cerebral cortex, and ileum of rats

1982 • 227 citations

Differential cardiovascular effects of calcium channel blocking agents: Potential mechanisms

1982 • 195 citations

Calcium antagonists receptor sites labeled with [3H]nitrendipine

1982 • 193 citations

The interaction of [3H]nitrendipine with receptors for calcium antagonists in the cerebral cortex and heart of rats

1982 • 186 citations

Study of the normal and failing isolated human heart: Decreased response of failing heart to isoproterenol

1983 • 172 citations

High affinity binding of a calcium channel antagonist to smooth and cardiac muscle

1982 • 168 citations

Specific binding of [3H]nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem

1982 • 158 citations

Number of Receptor Sites from Scatchard and Klotz Graphs: A Constructive Critique

1983 • 149 citations

Actions of nifedipine on calcium fluxes and contraction in isolated rat arteries.

1983 • 147 citations

[3H]-Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes.

1981 • 129 citations

Histamine receptors in the human heart

1980 • 120 citations

Differential effects of systemic and intracoronary calcium channel blocking agents on global and regional left ventricular function in conscious dogs

1981 • 108 citations

Influence of papaverine, D 600, and nifedipine on the effects of noradrenaline and calcium on the isolated aorta and mesenteric artery of the rabbit

1975 • 86 citations

[1] Theory of protein-ligand interaction

1975 • 81 citations

Binding of a Calcium Antagonist, [3H]Nitrendipine, to High Affinity Sites in Bovine Aortic Smooth Muscle and Canine Cardiac Membranes

1982 • 71 citations

MECHANISMS UNDERLYING THE CARDIOVASCULAR ACTION OF A NEW DIHYDROPYRIDINE VASODILATOR, YC‐93

1980 • 63 citations

[3H]-Nimodipine and [3H]-nitrendipine as tools to directly identify the sites of action of 1,4-dihydropyridine calcium antagonists in guinea-pig tissues. Tissue-specific effects of anions and ionic strength.

1982 • 42 citations

Specific inhibition of calcium channels by calcium ions in smooth muscle.

1982 • 30 citations

Effect of diazoxide, verapamil and compound D600 on isoproterenol and calcium-mediated dose-response relationships in isolated rabbit atrium

1977 • 30 citations

Mechanisms of Vasodilatation and Antivasoconstriction

1979 • 26 citations

Species variation in arterial-myocardial sensitivity to verapamil

1981 • 16 citations

Adrenergic pharmacology

2015 • 10 citations

The influence of some cardiodepressant drugs on the histamine-induced restoration of contractility in potassium-depolarized heart preparations.

1981 • 9 citations

The negative inotropic potency of compound D 600 in rat, guinea pig, and rabbit cardiac preparations

1980 • 8 citations

Comparative coronary vasodilatory effects of nifedipine and niludipine.

1981 • 5 citations

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