1,4‐Dihydropyridine Ca²⁺ channel antagonists and activators: A comparison of binding characteristics with pharmacology

Mechanisms of action of transmitters and other substances on smooth muscle.

1979 • 2,193 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

Calcium Channel

1981 • 1,184 citations

Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage

1983 • 1,148 citations

Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels

1983 • 1,010 citations

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

1983 • 869 citations

Calcium Channels in Excitable Cell Membranes

1983 • 725 citations

New developments in calcium ion channel antagonists

1983 • 525 citations

[3H]nitrendipine receptors in skeletal muscle.

1983 • 381 citations

Mechanisms of Calcium Antagonist-Induced Vasodilation

1983 • 370 citations

New Perspectives on Calcium Antagonists

1982 • 310 citations

Characterization of binding of the Ca++ channel antagonist, [3H]nitrendipine, to guinea-pig ileal smooth muscle.

1983 • 292 citations

Modulation of Synapse Formation by Cyclic Adenosine Monophosphate

1983 • 282 citations

[3H]nitrendipine-labeled calcium channels discriminate inorganic calcium agonists and antagonists.

1982 • 265 citations

Isosorbide Dinitrate and Nifedipine Treatment of Achalasia: A Clinical, Manometric and Radionuclide Evaluation

1982 • 263 citations

Calcium antagonism in heart and smooth muscle

1984 • 258 citations

Calcium depletion in frog muscle tubules: the decline of calcium current under maintained depolarization.

1981 • 256 citations

Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane?

1982 • 254 citations

Controlled Double-Blind Trial of Nifedipine in the Treatment of Raynaud's Phenomenon

1983 • 245 citations

Are dihydropyridine binding sites voltage sensitive calcium channels?

1984 • 234 citations

Calcium Antagonists and Cardiovascular Disease

1985 • 230 citations

The binding of [3H]nitrendipine to receptors for calcium channel antagonists in the heart, cerebral cortex, and ileum of rats

1982 • 227 citations

Nifedipine in hypertensive emergencies.

1983 • 224 citations

Sites of action of Ca2+ channel inhibitors

1983 • 224 citations

New Drugs Annual—Cardiovascular Drugs

1984 • 222 citations

Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists.

1983 • 219 citations

A unitary mechanism of calcium antagonist drug action.

1983 • 214 citations

Modern methods in pharmacology

1982 • 191 citations

High affinity binding of a calcium channel antagonist to smooth and cardiac muscle

1982 • 168 citations

Cellular Action of Calcium Channel Blocking Drugs

1984 • 159 citations

Specific binding of [3H]nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem

1982 • 158 citations

Dihydropyridine receptor in rat brain labeled with [3H]nimodipine.

1983 • 153 citations

Biochemistry of smooth muscle

1983 • 133 citations

[3H]-Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes.

1981 • 129 citations

Calcium antagonists: A new class of drugs

1983 • 125 citations

Calcium antagonists High-affinity binding and inhibition of calcium transport in a clonal cell line.

1982 • 125 citations

Specific calcium antagonist binding sites in brain

1982 • 119 citations

Value of QRS alteration in determining the site of origin of narrow QRS supraventricular tachycardia.

1983 • 112 citations

Effects of Nifedipine on the Smooth Muscle of the Human Urinary Tract in Vitro and in Vivo

1978 • 112 citations

Calcium Antagonists Pharmacodynamic Effects and Mechanism of Action

1983 • 105 citations

Calcium Antagonists Clinical Use in the Treatment of Arrhythmias

1983 • 104 citations

The calcium channel

1983 • 104 citations

Voltage-dependent calcium channels in pituitary cells in culture. I. Characterization by 45Ca2+ fluxes.

1984 • 101 citations

Calcium Antagonists Clinical Use in the Treatment of Systemic Hypertension

1983 • 98 citations

Autoradiographic visualization of [3H]nitrendipine binding sites in rat brain: Localization to synaptic zones

1982 • 98 citations

Temperature‐dependent regulation of d‐cis‐[³H]diltiazem binding to Ca²⁺ channels by 1,4‐dihydropyridine channel agonists and antagonists

1983 • 96 citations

Interaction between calcium ions and surface charge as it relates to calcium currents

1983 • 94 citations

Primary pulmonary hypertension: Beneficial therapy with diltiazem

1981 • 89 citations

Characteristics of the binding of [3H]nitrendipine to rabbit ventricular membranes: modification by other Ca++ channel antagonists and by the Ca++ channel agonist Bay K 8644.

1984 • 87 citations

Flunarizine, a Calcium Channel Blocker, in the Prophylactic Treatment of Migraine

1983 • 87 citations

Calcium Blockers. Mechanisms of Action and Clinical Applications.

1982 • 84 citations

Calcium channel antagonist binding sites labeled by 3H-nimodipine in human brain

1983 • 82 citations

Autoradiographic localization of a calcium channel antagonist, [3H]nitrendipine, binding site in rat brain

1983 • 76 citations

Structure-activity studies on nifedipine in isolated cardiac muscle

1979 • 72 citations

Binding of a Calcium Antagonist, [3H]Nitrendipine, to High Affinity Sites in Bovine Aortic Smooth Muscle and Canine Cardiac Membranes

1982 • 71 citations

Effects of metal cations and calmodulin antagonists on [3H] nitrendipine binding in smooth and cardiac muscle.

1984 • 71 citations

Afterload reduction with nifedipine in aortic insufficiency

1982 • 70 citations

Specific binding of the calcium antagonist [3H]nitrendipine to subcellular fractions isolated from canine myocardium. Evidence for high affinity binding to ryanodine-sensitive sarcoplasmic reticulum vesicles.

1983 • 69 citations

Binding of [3H]nimodipine to cardiac and smooth muscle membranes

1982 • 68 citations

Calcium channel activation: a different type of drug action.

1984 • 65 citations

The first American clinical trial of nifedipine in cardioplegia. A report of the first 12 month experience.

1981 • 59 citations

Binding of the calcium channel blocker nitrendipine to its receptor in purified sarcolemma from canine cardiac ventricle

1983 • 57 citations

Relationship of binding of a calcium channel blocker to inhibition of contraction in intact cultured embryonic chick ventricular cells.

1983 • 56 citations

The first American clinical trial of nifedipine in cardioplegia

1981 • 54 citations

Calcium Antagonists Clinical Use in the Treatment of Angina

1983 • 54 citations

Differential labelling of putative skeletal muscle calcium channels by [3H]-nifedipine, [3H]-nitrendipine, [3H]-nimodipine and [3H]-PN 200 110

1983 • 54 citations

Ca[2+] entry blockers, adenosine, and neurohumors

1983 • 53 citations

Nifedipine in the Treatment of Achalasia

1982 • 52 citations

Hemodynamic effects of verapamil in children and adolescents with hypertrophic cardiomyopathy.

1983 • 51 citations

Alpha-1 adrenoceptors and calcium in isolated canine coronary arteries.

1983 • 50 citations

Stimulation of Na+,K+-ATPase of isolated smooth muscle membranes by the Ca2+ channel inhibitors, nimodipine and nitrendipine

1984 • 48 citations

Diltiazem potentiates the negative inotropic action of nimodipine in heart

1983 • 48 citations

A calcium antagonist drug binding site in skeletal muscle sarcoplasmic reticulum: Evidence for a calcium channel

1983 • 46 citations

Haemodynamic effects of nifedipine and propranolol in patients with hypertrophic obstructive cardiomyopathy.

1982 • 44 citations

Voltage-and frequency-dependent block of diltiazem on the slow inward current and generation of tension in frog ventricular muscle

1983 • 43 citations

Radioreceptor and High‐Performance Liquid Chromatographic Assays for the Calcium Channel Antagonist Nitrendipine in Serum

1983 • 42 citations

Current awareness series

1984 • 41 citations

Oral Nifedipine in the Long-Term Management of Severe Chronic Heart Failure

1982 • 41 citations

Inhibition of myometrial activity by calcium antagonists.

1981 • 40 citations

Photoalteration of calcium channel blockade in the cardiac Purkinje fiber

1984 • 39 citations

Calcium-channel antagonist binding to isolated vascular smooth muscle membranes

1982 • 38 citations

New Calcium Antagonists: Recent Developments and Prospects

1984 • 36 citations

[3H]Nimodipine specific binding to cardiac myocytes and subcellular fractions

1983 • 36 citations

Influence of cinnarizine on the labyrinth and on vertigo

1962 • 36 citations

Calcium in biological systems

1983 • 35 citations

Mechanisms of action of membrane calcium channel blockers and intracellular calcium antagonists

1983 • 34 citations

Calcium antagonists for cardiovascular disease

1993 • 25 citations

β-Blockers and Calcium Antagonists

1983 • 24 citations

A new vasoconstrictor 1,4-dihydropyririine derivative, YC-170

1982 • 23 citations

Specific Calcium Antagonists in the Treatment of Peripheral Vascular Disease

1979 • 22 citations

Calcium antagonist blockade of slow action potentials in cultured chick heart cells

1983 • 20 citations

The action of specific Ca antagonists on cardiac electrical activity

1982 • 20 citations

Pharmacological Inhibition of Uterine Activity

1982 • 20 citations

A double-blind placebo controlled study of cinnarizine in the prophylaxis of seasickness.

1980 • 19 citations

Depression of Contractions of Rabbit Aorta and Guinea Pig Vena cava by Mesudipine and Other Slow Channel Blockers

1983 • 18 citations

Chemistry of calcium antagonists.

1983 • 17 citations

Double-Blind Placebo-Controlled Studies with Flunarizine in Venous Insufficiency

1980 • 17 citations

Introduction

1982 • 17 citations

Calcium Antagonists in the Treatment of Individuals with Ischemic Heart Disease

1982 • 14 citations

Does [³H]Nifedipine Label the Calcium Channel in Rabbit Myocardium?

1983 • 14 citations

Chemical Pharmacology of Calcium Antagonists

1982 • 13 citations

Management of Cardiac Arrhythmias with Tiapamil

1982 • 9 citations

Nitrendipine

1984 • 7 citations

[Calcium antagonists: recent developments].

1995 • 4 citations

Regional myocardial lidocaine concentration following continuous intravenous infusion early and late after myocardial infarction

1982 • 4 citations

Responsiveness of Various Symptoms of Vascular Disorders to Calcium Antagonists

1979 • 4 citations

Recent Developments and Prospects

2005 • 2 citations