Nucleotide Transport Through the Cystic Fibrosis Transmembrane Conductance Regulator

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

CFTR as a cAMP-Dependent Regulator of Sodium Channels

1995 • 1,074 citations

A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport

1993 • 939 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

1995 • 647 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Altered Regulation of Airway Epithelial Cell Chloride Channels in Cystic Fibrosis

1986 • 568 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.

1986 • 561 citations

Generation of cAMP-Activated Chloride Currents by Expression of CFTR

1991 • 550 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis

1991 • 495 citations

Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter.

1992 • 410 citations

The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.

1994 • 354 citations

Expression and characterization of the cystic fibrosis transmembrane conductance regulator

1990 • 340 citations

Pharmacology and electrophysiology of ATP-activated ion channels

1992 • 326 citations

THE RISK OF CANCER AMONG PATIENTS WITH CYSTIC FIBROSIS

1995 • 296 citations

The human MDR3 P‐glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

1994 • 278 citations

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1991 • 271 citations

Cl ^- Channels in CF: Lack of Activation by Protein Kinase C and cAMP-Dependent Protein Kinase

1989 • 267 citations

Evidence for reduced Cl‐ and increased Na+ permeability in cystic fibrosis human primary cell cultures.

1988 • 265 citations

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

1993 • 257 citations

Cloning and Expression of a cDNA Coding for a Rat Liver Plasma Membrane Ecto-ATPase

1989 • 240 citations

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

1995 • 191 citations

The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.

1992 • 190 citations

Failure of the Cystic Fibrosis Transmembrane Conductance Regulator to Conduct ATP

1996 • 184 citations

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.

1988 • 176 citations

Control of CFTR chloride conductance by ATP levels through non-hydrolytic binding

1992 • 167 citations

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1992 • 147 citations

ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.

1988 • 143 citations

Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells

1990 • 122 citations

Isolation and characterization of Drosophila multidrug resistance gene homologs.

1991 • 118 citations

Purified Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Does Not Function as an ATP Channel

1996 • 115 citations

The rat liver ecto-ATPase is also a canalicular bile acid transport protein.

1993 • 101 citations

A cohort study of cystic fibrosis and malignancy

1993 • 101 citations

The biological actions of extracellular ATP

1989 • 96 citations

A proposal for the role of ecto-enzymes and adenylates in traumatic shock

1980 • 93 citations

Genetics of multidrug resistance: relationship of a cloned gene to the complete multidrug resistant phenotype.

1987 • 81 citations

Immunochemical characterization of two isoforms of rat liver ecto-ATPase that show an immunological and structural identity with a glycoprotein cell-adhesion molecule with Mr 105,000

1991 • 75 citations

Adenosine: A Retaliatory Metabolite or Not?

1990 • 53 citations

External ATP and its analogs activate the cystic fibrosis transmembrane conductance regulator by a cyclic AMP-independent mechanism

1994 • 50 citations

Lack of Conventional ATPase Properties in CFTR Chloride Channel Gating

1996 • 47 citations

High‐ and low‐affinity binding sites for [³H]‐α,β‐methylene ATP in rat urinary bladder membranes

1990 • 46 citations

Analysis of Mdr50: A Drosophila P-Glycoprotein/Multidrug Resistance Gene Homolog

1993 • 46 citations

Chloride Transport in Biological Membranes

1982 • 43 citations

A1 adenosine receptors inhibit chloride transport in the shark rectal gland. Dissociation of inhibition and cyclic AMP.

1990 • 40 citations

Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype

1995 • 39 citations

A Comparison of Ectonucleotidase Activities on Vascular Endothelial and Smooth Muscle Cells^a

1990 • 38 citations

Endogenous adenosine is an autacoid feedback inhibitor of chloride transport in the shark rectal gland.

1991 • 38 citations

Osteoclast ATP receptor activation leads to a transient decrease in intracellular pH

1995 • 34 citations

Phosphorylation‐Dependent Regulation of Apical Membrane Chloride Channels in Normal and Cystic Fibrosis Airway Epithelium^a

1989 • 9 citations

STUDIES ON ENZYME ACTION

1926 • 2 citations

Swiss launch environment programme

1992 • 1 citations