The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

1992 • 1,230 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

1991 • 1,108 citations

Single channel recording

1984 • 981 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells

1990 • 706 citations

Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

1990 • 576 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Generation of cAMP-Activated Chloride Currents by Expression of CFTR

1991 • 550 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

Cystic fibrosis: a disease in electrolyte transport

1990 • 510 citations

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

1991 • 508 citations

Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis

1991 • 495 citations

Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR

1992 • 418 citations

The multidrug resistance (mdr1) gene product functions as an ATP channel.

1993 • 372 citations

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1991 • 271 citations

Evidence for reduced Cl‐ and increased Na+ permeability in cystic fibrosis human primary cell cultures.

1988 • 265 citations

Diphenylamine-2-carboxylate, a blocker of the Cl−-conductive pathway in Cl−-transporting epithelia

1985 • 181 citations

Anion channels for amino acids in MDCK cells

1992 • 172 citations

Control of CFTR chloride conductance by ATP levels through non-hydrolytic binding

1992 • 167 citations

Cystic Fibrosis: Horizons

1985 • 148 citations

Introduction to a submolecular biology

1961 • 146 citations

An Introduction to Physical Biochemistry.

1965 • 98 citations

The biological actions of extracellular ATP

1989 • 96 citations

A proposal for the role of ecto-enzymes and adenylates in traumatic shock

1980 • 93 citations

G alpha i-3 regulates epithelial Na+ channels by activation of phospholipase A2 and lipoxygenase pathways.

1990 • 86 citations

Intrinsic anion channel activity of the recombinant first nucleotide binding fold domain of the cystic fibrosis transmembrane regulator protein.

1992 • 53 citations

External ATP and its analogs activate the cystic fibrosis transmembrane conductance regulator by a cyclic AMP-independent mechanism

1994 • 50 citations

A Comparison of Ectonucleotidase Activities on Vascular Endothelial and Smooth Muscle Cells^a

1990 • 38 citations

Identification of a defective cAMP-stimulated Cl- channel in cystic fibrosis fibroblasts.

1987 • 36 citations

Phosphorylation‐Dependent Regulation of Apical Membrane Chloride Channels in Normal and Cystic Fibrosis Airway Epithelium^a

1989 • 9 citations