The Secretory Capacity of a Cell Depends on the Efficiency of Endoplasmic Reticulum-Associated Degradation

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

Quality control in the endoplasmic reticulum

2003 • 2,061 citations

Roles of N-Linked Glycans in the Endoplasmic Reticulum

2004 • 1,940 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

Production of monoclonal antibodies: Strategy and tactics

1980 • 1,594 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Orchestrating the unfolded protein response in health and disease

2002 • 1,163 citations

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

2001 • 1,048 citations

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

2004 • 978 citations

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

2004 • 942 citations

Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

2002 • 909 citations

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

2003 • 843 citations

Molecular pathways to neurodegeneration

2004 • 732 citations

Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

2001 • 693 citations

A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response

2003 • 670 citations

Quality control in the endoplasmic reticulum protein factory

2003 • 670 citations

A membrane protein required for dislocation of misfolded proteins from the ER

2004 • 669 citations

XBP1

2004 • 627 citations

How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum.

1994 • 617 citations

The protein disulphide-isomerase family: unravelling a string of folds

1999 • 504 citations

An essential role in liver development for transcription factor XBP-1

2000 • 503 citations

Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera Toxin

2001 • 483 citations

Role of EDEM in the Release of Misfolded Glycoproteins from the Calnexin Cycle

2003 • 464 citations

Endoplasmic Reticulum Stress and the Development of Diabetes

2002 • 455 citations

EDEM As an Acceptor of Terminally Misfolded Glycoproteins Released from Calnexin

2003 • 446 citations

Quality Control and Protein Folding in the Secretory Pathway

2003 • 421 citations

Biosynthesis and Degradation of CFTR

1999 • 406 citations

Sequential Waves of Functionally Related Proteins Are Expressed When B Cells Prepare for Antibody Secretion

2003 • 351 citations

Chaperone Selection During Glycoprotein Translocation into the Endoplasmic Reticulum

2000 • 331 citations

Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells

2002 • 297 citations

Integration of endoplasmic reticulum signaling in health and disease

1999 • 280 citations

A proteolytic system that compensates for loss of proteasome function

1998 • 271 citations

Endoplasmic Reticulum Oxidoreductin 1-Lβ (ERO1-Lβ), a Human Gene Induced in the Course of the Unfolded Protein Response

2000 • 260 citations

Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER

2002 • 226 citations

Repertoire selection by pre‐B‐cell receptors and B‐cell receptors, and genetic control of B‐cell development from immature to mature B cells

2000 • 216 citations

Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein

1998 • 206 citations

Export of a Cysteine-Free Misfolded Secretory Protein from the Endoplasmic Reticulum for Degradation Requires Interaction with Protein Disulfide Isomerase

1999 • 194 citations

Molecular Biology of B Cells

2015 • 188 citations

Protein disulfide isomerases exploit synergy between catalytic and specific binding domains

2002 • 180 citations

Ubiquitination Is Required for the Retro-translocation of a Short-lived Luminal Endoplasmic Reticulum Glycoprotein to the Cytosol for Degradation by the Proteasome

1998 • 175 citations

Coordinated Nonvectorial Folding in a Newly Synthesized Multidomain Protein

2002 • 167 citations

Elucidation of the molecular logic by which misfolded α1-antitrypsin is preferentially selected for degradation

2003 • 161 citations

A Novel Stress-induced EDEM Variant Regulating Endoplasmic Reticulum-associated Glycoprotein Degradation

2004 • 157 citations

Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins

2004 • 153 citations

The protein disulphide-isomerase family: unravelling a string of folds

1999 • 142 citations

Orchestrating the unfolded protein response in health and disease

2002 • 131 citations

Dislocation of Type I Membrane Proteins from the ER to the Cytosol Is Sensitive to Changes in Redox Potential

1998 • 123 citations

Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response

2003 • 121 citations

Glycoprotein Quality Control in the Endoplasmic Reticulum

2001 • 120 citations

Degradation of unassembled soluble Ig subunits by cytosolic proteasomes: evidence that retrotranslocation and degradation are coupled events

2000 • 99 citations

In situ hybridization studies suggest a role for the basic region‐leucine zipper protein hXBP‐1 in exocrine gland and skeletal development during mouse embryogenesis

1993 • 97 citations

Pre-Golgi degradation of yeast prepro-alpha-factor expressed in a mammalian cell. Influence of cell type-specific oligosaccharide processing on intracellular fate

1993 • 76 citations

A complex between peptide: N -glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins

2004 • 71 citations

Insufficient Folding of Type IV Collagen and Formation of Abnormal Basement Membrane-like Structure in Embryoid Bodies Derived from Hsp47-Null Embryonic Stem Cells

2004 • 64 citations

Extension of lipid-linked oligosaccharides is a high-priority aspect of the unfolded protein response: endoplasmic reticulum stress in Type I congenital disorder of glycosylation fibroblasts

2002 • 51 citations

Alpha-1-antitrypsin Deficiency: Biochemistry and Clinical Manifestations

1996 • 48 citations

EDEM Contributes to Maintenance of Protein Folding Efficiency and Secretory Capacity

2004 • 47 citations

cld and lec23 are disparate mutations that affect maturation of lipoprotein lipase in the endoplasmic reticulum

1999 • 34 citations

Heavy chain disease

2002 • 34 citations

Immunoglobulin Assembly and Secretion

2004 • 32 citations