CpG DNA Augments the Immunogenicity of Plasmid DNA Vaccines

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

1996 • 1,498 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

1997 • 1,008 citations

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

1997 • 919 citations

Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine

1998 • 844 citations

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

1998 • 809 citations

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

1988 • 731 citations

CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen

1998 • 684 citations

Gene inoculation generates immune responses against human immunodeficiency virus type 1.

1993 • 655 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1997 • 526 citations

Contribution of CpG motifs to the immunogenicity of DNA vaccines.

1997 • 519 citations

Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.

1994 • 453 citations

Gene Therapy by Intramuscular Injection of Plasmid DNA: Studies on Firefly Luciferase Gene Expression in Mice

1993 • 440 citations

Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients

1998 • 409 citations

Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-α

1996 • 403 citations

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

1998 • 402 citations

CpG‐containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants

1997 • 390 citations

Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA.

1991 • 378 citations

DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth

1992 • 370 citations

Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA

1993 • 344 citations

CpG motifs as immune adjuvants

1999 • 313 citations

Pervasive CpG suppression in animal mitochondrial genomes.

1994 • 238 citations

Dna Methylation and its Possible Biological Roles

1981 • 202 citations

Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA.

1989 • 202 citations

Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA.

1995 • 126 citations

Procaryotic and eucaryotic traits of DNA methylation in spiroplasmas (mycoplasmas)

1985 • 102 citations

Transcriptional repression by methylation: cooperativity between a CpG cluster in the promoter and remote CpG‐rich regions

1996 • 28 citations

Immunogenicity and Efficacy of a DNA Vaccine in Aged Mice

1998 • 17 citations