CpG motifs as immune adjuvants

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

1996 • 1,498 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

1997 • 919 citations

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.

1988 • 791 citations

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

1988 • 731 citations

Contribution of CpG motifs to the immunogenicity of DNA vaccines.

1997 • 519 citations

Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.

1994 • 453 citations

Gene Therapy by Intramuscular Injection of Plasmid DNA: Studies on Firefly Luciferase Gene Expression in Mice

1993 • 440 citations

Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-α

1996 • 403 citations

Pervasive CpG suppression in animal mitochondrial genomes.

1994 • 238 citations

Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes.

1990 • 210 citations

Dna Methylation and its Possible Biological Roles

1981 • 202 citations

Induction of neonatal tolerance by plasmid DNA vaccination of mice.

1996 • 131 citations

Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA.

1995 • 126 citations

ELISPOT Assay to Detect Cytokine‐Secreting Murine and Human Cells

2008 • 100 citations

Gamma interferon, cytokine-induced macrophage activation, and antimicrobial host defense in vitro, in animal models, and in humans

1990 • 71 citations

Acquisition and maturation of expressed B cell repertoires in normal and autoimmune mice.

1988 • 57 citations

<scp>ELISPOT</scp> Assay to Detect Cytokine‐Secreting Murine and Human Cells

1994 • 40 citations

Activation of IL-4 and IL-6 secreting cells by antigen

1995 • 8 citations