Ascorbic acid-dehydroascorbate induces cell cycle arrest at G2/M DNA damage checkpoint during oxidative stress

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Principles of CDK regulation

1995 • 3,267 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

1997 • 1,332 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Redox Regulation of NF-kappa B Activation

1997 • 852 citations

Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.

1991 • 784 citations

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

1982 • 704 citations

Oxidative DNA damage and senescence of human diploid fibroblast cells.

1995 • 697 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1997 • 541 citations

Cell Cycle Control of DNA Replication

1996 • 512 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid

1993 • 496 citations

Action of ascorbic acid as a scavenger of active and stable oxygen radicals

1991 • 484 citations

Differential Activation of Mitogen-Activated Protein Kinases by H ₂ O ₂ and O ₂ ⁻ in Vascular Smooth Muscle Cells

1995 • 416 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

Age-related Decline in Mitogen-activated Protein Kinase Activity in Epidermal Growth Factor-stimulated Rat Hepatocytes

1996 • 351 citations

Transient Adaptation to Oxidative Stress in Mammalian Cells

1995 • 300 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

転写因子NF‐κBとAP‐1の活性化に及ぼすチオレドキシンと抗酸化剤の異なった効果

1994 • 259 citations

Ascorbic Acid Induces Alkaline Phosphatase, Type X Collagen, and Calcium Deposition in Cultured Chick Chondrocytes

1989 • 243 citations

p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.

1991 • 235 citations

Accumulation of Vitamin C (Ascorbate) and Its Oxidized Metabolite Dehydroascorbic Acid Occurs by Separate Mechanisms

1995 • 183 citations

Resolution of the Facilitated Transport of Dehydroascorbic Acid from Its Intracellular Accumulation as Ascorbic Acid

1995 • 167 citations

Mutagaenic action of ascorbic acid

1976 • 159 citations

Genetic toxicology of ascorbic acid

1984 • 153 citations

Ascorbate stimulation of PAT cells causes an increase in transcription rates and a decrease in degradation rates of procollagen mRNA

1984 • 138 citations

Sequential Dephosphorylation of p34 on Thr-14 and Tyr-15 at the Prophase/Metaphase Transition

1996 • 136 citations

The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells.

1997 • 135 citations

Modulation of Activator Protein‐1 (AP‐1) Transcription Factor and Protein Kinase C by Hydrogen Peroxide and <scp>d</scp>‐α‐Tocopherol in Vascular Smooth Muscle Cells

1994 • 116 citations

Vitamin C is positive in the DNA synthesis inhibition and sister-chromatid exchange tests

1979 • 97 citations

Effect of antioxidant vitamin supplementation on DNA damage and repair in human lymphoblastoid cells

1997 • 89 citations

Enhancement of the chromosome-damaging action of ascorbate by transition metals.

1979 • 87 citations

Variation in the Expression and/or Phosphorylation of the Human Low Molecular Weight Stress Protein during in Vitro Cell Differentiation

1995 • 86 citations

Dehydroascorbic Acid and Cell Division

1970 • 76 citations

Low-Level Oxidative Stress Causes Cell Cycle-Specific Arrest in Cultured Cells

1995 • 75 citations

The SCE-inducing capacity of vitamin C: Investigations in vitro and in vivo

1980 • 72 citations

Ascorbic acid accumulation and transport in human fibroblasts

1993 • 70 citations

N-Glycosylation of the Human Granulocyte-Macrophage Colony-stimulating Factor Receptor α Subunit Is Essential for Ligand Binding and Signal Transduction

1995 • 69 citations

Ascorbate modulation of chondrocyte gene expression is independent of its role in collagen secretion.

1994 • 67 citations

Inhibition of cyclophosphamide and mitomycin C-induced sister chromatid exchanges in mice by vitamin C.

1986 • 62 citations

Antimutagenic and promutagenic activity of ascorbic acid during oxidative stress

1997 • 61 citations

Micronutrients and Their Influence on Mutagenicity and Malignant Transformationa

1993 • 44 citations

Mutagenic activity of ascorbate in mammalian cell cultures

1980 • 43 citations

Mutagenesis of AS52 cells by low concentrations of lead(II) and mercury(II)

1996 • 41 citations

Sites and Mechanisms of Low-Level Oxidative Stress in Cultured Cells

1995 • 29 citations

Ascorbic acid enhances forskolin-induced cyclic AMP production and pro-ANF mRNA expression of hypothalamic neurons in culture.

1993 • 20 citations

Cell cycle constraints on peroxide- and radiation-induced inhibitory checkpoints.

1995 • 12 citations