Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

The periodic association of MAP2 with brain microtubules in vitro.

1979 • 510 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

[37] Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle

1988 • 418 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

1990 • 256 citations

Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669

1991 • 215 citations

Interleukin 1 and tumor necrosis factor activate common multiple protein kinases in human fibroblasts

1991 • 160 citations

Heterogeneous expression of four MAP kinase isoforms in human tissues

1992 • 143 citations

Tyrosine Phosphorylation of Actin in Dictyostelium Associated with Cell-Shape Changes

1993 • 118 citations

Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein

1989 • 117 citations

IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism.

1989 • 116 citations

Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.

1991 • 100 citations

Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.

1990 • 96 citations

Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins

1988 • 86 citations

γ‐Phosphate‐linked ATP‐Sepharose for the affinity purification of protein kinases

1993 • 76 citations

Interleukin 1 and tumour necrosis factor activate the mitogen‐activated protein (MAP) kinase kinase in cultured cells

1993 • 73 citations

Accelerated high‐sensitivity microsequencing of proteins and peptides using a miniature reaction cartridge

1992 • 72 citations

Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.

1993 • 72 citations

Signal transduction pathway for IL-1. Involvement of a pertussis toxin-sensitive GTP-binding protein in the activation of adenylate cyclase.

1989 • 65 citations

Enhanced phosphorylation of 65 and 74 kDa proteins by tumor necrosis factor and interleukin-1 in human peripheral blood mononuclear cells

1990 • 41 citations

Interleukin-1-induced signaling in T-cells. Evidence for the involvement of phosphatases PP1 and PP2A in regulating protein kinase C-mediated protein phosphorylation and interleukin-2 synthesis.

1993 • 28 citations

Evidence for phosphorylation of actin by the insulin receptor‐associated protein kinase from human placenta

1983 • 28 citations

Molecular Cloning, Expression, and Characterization of the Human Mitogen-Activated Protein Kinase p44^erk1

1993 • 16 citations