Amphiphilicity is essential for mitochondrial presequence function.

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Determination of the helix and β form of proteins in aqueous solution by circular dichroism

1974 • 2,040 citations

Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector

1986 • 1,053 citations

Mitochondrial targeting sequences may form amphiphilic helices.

1986 • 1,019 citations

Compilation of published signal sequences

1984 • 784 citations

A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers.

1986 • 493 citations

Import of proteins into mitochondria. Energy-dependent uptake of precursors by isolated mitochondria.

1982 • 351 citations

Interactions between membranes and cytolytic peptides

1986 • 304 citations

The first twelve amino acids (less than half of the pre-sequence) of an imported mitochondrial protein can direct mouse cytosolic dihydrofolate reductase into the yeast mitochondrial matrix.

1985 • 279 citations

A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences.

1984 • 251 citations

Transport of proteins into mitochondria: a potassium diffusion potential is able to drive the import of ADP/ATP carrier.

1985 • 245 citations

The amino-terminal region of an imported mitochondrial precursor polypeptide can direct cytoplasmic dihydrofolate reductase into the mitochondrial matrix.

1984 • 236 citations

Artificial mitochondrial presequences.

1986 • 203 citations

Targeting of pre-ornithine transcarbamylase to mitochondria: Definition of critical regions and residues in the leader peptide

1986 • 172 citations

Sequences from a prokaryotic genome or the mouse dihydrofolate reductase gene can restore the import of a truncated precursor protein into yeast mitochondria.

1987 • 160 citations

Voltage-dependent trans-bilayer orientation of melittin.

1982 • 135 citations

A cytosolic protein contains a cryptic mitochondrial targeting signal

1987 • 101 citations

Structural analysis and amphiphilic properties of a chemically synthesized mitochondrial signal peptide.

1986 • 83 citations

Arginine in the leader peptide is required for both import and proteolytic cleavage of a mitochondrial precursor.

1985 • 74 citations

Amino-terminal deletions in the presequence of an imported mitochondrial protein block the targeting function and proteolytic cleavage of the presequence at the carboxy terminus.

1987 • 62 citations

Targeting efficiency of a mitochondrial pre-sequence is dependent on the passenger protein.

1986 • 60 citations

Independent mutations at the amino terminus of a protein act as surrogate signals for mitochondrial import.

1987 • 59 citations

Thermodynamic characterization of interactions between ornithine transcarbamylase leader peptide and phospholipid bilayer membranes

1987 • 54 citations

The amino acid sequence of dihydrofolate reductase from the mouse lymphoma L1210.

1979 • 52 citations

Primary structure requirements for correct sorting of the yeast mitochondrial protein ADH III to the yeast mitochondrial matrix space.

1987 • 44 citations

Primary Structure Requirements for Correct Sorting of the Yeast Mitochondrial Protein ADH III to the Yeast Mitochondrial Matrix Space

1987 • 14 citations

[Surgical aid in the Soviet Union (on the 50th anniversary of the formation of the USSR)].

1972 • 2 citations