Insulin Binding and Glucose Transport

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN

1960 • 2,983 citations

Nuclei from Rat Liver: Isolation Method That Combines Purity with High Yield

1966 • 1,687 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Control of proliferation in animal cells

1974 • 1,177 citations

Isolation of pure and unaltered liver nuclei morphology and biochemical composition

1956 • 1,119 citations

The Syndromes of Insulin Resistance and Acanthosis Nigricans

1976 • 1,086 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Insulin interactions with its receptors: Experimental evidence for negative cooperativity

1973 • 717 citations

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

1966 • 680 citations

Development of 3T3‐like lines from Balb/c mouse embryo cultures: Transformation susceptibility to SV40

1968 • 662 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Membrane receptors for hormones and neurotransmitters.

1976 • 573 citations

A procedure for the isolation of enzymically active rat-liver nuclei

1964 • 549 citations

The concept of carrier transport and its corollaries in pharmacology.

1961 • 541 citations

Monoiodoinsulin: Demonstration of its biological activity and binding to fat cells and liver membranes

1971 • 521 citations

Insulin Receptors in the Liver: Specific Binding of [ ¹²⁵ I]Insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity

1971 • 494 citations

The regulation of amino acid transport in animal cells

1978 • 467 citations

The Relationship between the Insulin-binding Capacity of Fat Cells and the Cellular Response to Insulin

1971 • 464 citations

Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance

1975 • 434 citations

Inability of diffusion to account for placental glucose transfer in the sheep and consideration of the kinetics of a possible carrier transfer

1952 • 425 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

1973 • 408 citations

The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes.

1980 • 388 citations

INTERACTION OF INSULIN WITH THE CELL MEMBRANE: THE PRIMARY ACTION OF INSULIN

1969 • 381 citations

Studies on Rat Adipose Tissue in Vitro

1958 • 371 citations

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.

1977 • 371 citations

Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake.

1975 • 367 citations

An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase

1970 • 346 citations

Transport of nucleosides, nucleic acid bases, choline and glucose by animal cells in culture

1974 • 338 citations

Mechanism of insulin action on glucose transport in the isolated rat adipose cell. Enhancement of the number of functional transport systems.

1978 • 330 citations

Reduction of disulfides by thioredoxin. Exceptional reactivity of insulin and suggested functions of thioredoxin in mechanism of hormone action.

1979 • 324 citations

Characteristics of the Human Lymphocyte Insulin Receptor

1973 • 320 citations

Methods in receptor research

1976 • 317 citations

Sugar transport in the red blood cell: structure-activity relationships in substrates and antagonists.

1961 • 301 citations

Characterization of the Insulin and Somatomedin-C Receptors in Human Placental Cell Membranes

1974 • 301 citations

Properties of the Insulin Receptor Isolated from Liver and Fat Cell Membranes

1972 • 299 citations

Peptide hormone binding to receptors: A review of direct studies in vitro

1973 • 286 citations

A Unifying Hypothesis Concerning the Nature of Malignant Growth

1972 • 282 citations

Hexose Transport in Normal and in Rous Sarcoma Virus-transformed Cells

1973 • 281 citations

Increased Uptake of Amino Acids and 2-Deoxy-D-Glucose by Virus-Transformed Cells in Culture

1972 • 277 citations

Insulin Receptor Deficiency in Genetic and Acquired Obesity

1975 • 262 citations

Prolactin Receptors in Rat Liver: Possible Induction by Prolactin

1975 • 261 citations

Biochemical Studies on the Mode of Action of Cytochalasin B

1974 • 256 citations

Alterations in Insulin Binding Induced by Changes in Vivo in the Levels of Glucocorticoids and Growth Hormone*

1978 • 246 citations

Studies of Tissue Permeability

1963 • 245 citations

Effects of Autoantibodies to the Insulin Receptor on Isolated Adipocytes

1977 • 244 citations

Insulin receptor: covalent labeling and identification of subunits.

1979 • 243 citations

Biochemistry of Membrane Transport

1977 • 235 citations

Biological Activities of Steroids in Relation to Cancer

1961 • 232 citations

Guanosine 3′:5′-Cyclic Monophosphate and the Action of Insulin and Acetylcholine

1973 • 232 citations

Properties of the Insulin Receptor of Isolated Fat Cell Membranes

1971 • 227 citations

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

1978 • 223 citations

Intracellular Translocation of Iodine-125-Labeled Insulin: Direct Demonstration in Isolated Hepatocytes

1978 • 220 citations

Affinity Chromatography and Purification of the Insulin Receptor of Liver Cell Membranes

1972 • 219 citations

Photoaffinity labeling of insulin receptor of rat adiopocyte plasma membrane.

1978 • 216 citations

Permeation of Glucose by Simple and Facilitated Diffusion by Novikoff Rat Hepatoma Cells in Suspension Culture and Its Relationship to Glucose Metabolism

1972 • 215 citations

Comparison of Plasma Insulin Levels Following Administration of Tolbutamide and Glucose

1960 • 212 citations

Evidence for the Involvement of Sulfhydryl Oxidation in the Regulation of Fat Cell Hexose Transport by Insulin

1974 • 209 citations

Insulin binding to the human lymphocyte receptor. Evaluation of the negative cooperativity model.

1977 • 205 citations

Regulation of glucose uptake by muscle. 3. The effects of insulin, anoxia, salicylate and 2:4-dinitrophenol on membrane transport and intracellular phosphorylation of glucose in the isolated rat heart

1959 • 203 citations

Central role for magnesium in coordinate control of metabolism and growth in animal cells.

1975 • 202 citations

Adenylate cyclase activation by the .beta.-adrenergic receptors as a diffusion-controlled process

1979 • 199 citations

The Inhibition of Sugar Transport in Chick Embryo Fibroblasts by Cytochalasin B

1973 • 196 citations

Intracellular polypeptide hormone receptors. The demonstration of specific binding sites for insulin and human growth hormone in Golgi fractions isolated from the liver of female rats.

1978 • 196 citations

Photoaffinity labeling of insulin receptor proteins of liver plasma membrane preparations

1980 • 195 citations

Sugar and Amino Acid Transport by Cells in Culture — Differences between Normal and Malignant Cells

1972 • 192 citations

Purification and properties of insulin receptors from rat liver membranes

1977 • 188 citations

Stimulation of Glucose Transport in Cultures of Density-Inhibited Chick Embryo Cells

1971 • 177 citations

Cuprammonium-Glycoside Complexes

1951 • 175 citations

Studies on Rat Adipose Tissue in Vitro

1958 • 174 citations

Regulation of glucose uptake by muscle. 2. The effects of insulin, anaerobiosis and cell poisons on the penetration of isolated rat diaphragm by sugars

1958 • 173 citations

Inhibition of glucose transport in the human erythrocyte by cytochalasin B

1973 • 172 citations

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography.

1978 • 171 citations

Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action.

1977 • 171 citations

Perturbation of the Insulin Receptor of Isolated Fat Cells with Proteolytic Enzymes

1971 • 171 citations

Reversible association of cytochalasin B with the human erythrocyte membrane. Inhibition of glucose transport and the stoichiometry of cytochalasin binding

1973 • 171 citations

Effect of Phytohemagglutinin on Lymphocyte Membrane Transport

1971 • 169 citations

ROLE OF CYCLIC-3′,5′-AMP IN THE RESPONSE OF ADIPOSE TISSUE TO INSULIN

1966 • 165 citations

The Insulin Receptor in Vertebrates Is Functionally More Conserved during Evolution than Insulin Itself

1979 • 164 citations

Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients

1976 • 162 citations

Destruction and Restoration of the Insulin Effector System of Isolated Fat Cells

1969 • 161 citations

Effect of pressure development on membrane transport of glucose in isolated rat heart

1967 • 160 citations

Sugar Transport in Chick Embryo Fibroblasts

1974 • 160 citations

Hexose Transport in Isolated Brown Fat Cells

1974 • 159 citations

Enhanced Permeability to Sugar Associated with Muscle Contraction

1967 • 158 citations

Biochemical Studies on the Mode of Action of Cytochalasin B

1974 • 157 citations

Insulin Receptors in Human and Animal Placental Tissue

1974 • 155 citations

Impairment of insulin binding to the fat cell plasma membrane in the obese hyperglycemic mouse

1972 • 155 citations

ACTION OF CYTOCHALASIN D ON CELLS OF ESTABLISHED LINES

1974 • 154 citations

Emergence of Insulin Receptors on Human Lymphocytes During In Vitro Transformation

1972 • 153 citations

Insulin binding to liver plasm membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors.

1975 • 152 citations

The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes

1975 • 150 citations

The Role of Membranes in Metabolic Regulation

1972 • 148 citations

Binding of insulin to isolated nuclei.

1976 • 146 citations

Membrane Sialic Acid and the Mechanism of Insulin Action in Adipose Tissue Cells

1971 • 144 citations

Effects of Age and Obesity on Insulin Binding to Isolated Adipocytes12¹²

1975 • 144 citations

Asymmetry of the hexose transfer system in human erythrocytes. Comparison of the effects of cytochalasin B, phloretin and maltose as competitive inhibitors.

1978 • 144 citations

Induction of sugar transport in chick embryo fibroblasts by hexose starvation. Evidence for transcriptional regulation of transport

1975 • 142 citations

Studies of the glucose-transport system in the rabbit erythrocyte

1964 • 140 citations

Cytochalasin B and the kinetics of inhibition of biological transport. A case of asymmetric binding to the glucose carrier

1978 • 137 citations

pH AND POPULATION DENSITY IN THE REGULATION OF ANIMAL CELL MULTIPLICATION

1971 • 136 citations

Adenosine Triphosphate-dependent Inhibition of Insulin-stimulated Glucose Transport in Fat Cells

1974 • 135 citations

Cyclic Adenosine Monophosphate-dependent Phosphorylation of Specific Fat Cell Membrane Proteins by an Endogenous Membrane-bound Protein Kinase

1974 • 135 citations

Entry of Insulin Into Human Cultured Lymphocytes: Electron Microscope Autoradiographic Analysis

1978 • 135 citations

Effects of epinephrine and insulin on phosphopeptide metabolism in adipocytes.

1976 • 133 citations

Characterization of the insulin receptor in its membrane environment by radiation inactivation.

1980 • 131 citations

Coordinate modulation of D-glucose transport activity and bilayer fluidity in plasma membranes derived from control and insulin-treated adipocytes.

1980 • 128 citations

Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin.

1978 • 126 citations

Sulphonylureas increase the number of insulin receptors

1978 • 125 citations

Intracellular polypeptide hormone receptors. Characterization of insulin binding sites in Golgi fractions from the liver of female rats.

1978 • 123 citations

Interactions of polypeptide hormones with cell membrane specific receptors: Studies with insulin and glucagon

1976 • 122 citations

Enhancement of Hexose Entry into Chick Fibroblasts by Starvation: Differential Effect on Galactose and Glucose

1972 • 120 citations

Stimulation of Division of Density Inhibited Fibroblasts Glucocorticoids

1973 • 118 citations

Detection of Endogenous Immunoreactive Prolactin in Rat Mammary Epithelial Cells During Lactation1¹

1976 • 118 citations

Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation

1976 • 117 citations

INSULIN BINDING TO RAT LIVER GOLGI FRACTIONS

1973 • 117 citations

Increased insulin binding by hepatic plasma membranes from diabetic rats: normalization by insulin therapy.

1977 • 115 citations

Characterization of the glucose transporter from human erythrocytes

1978 • 115 citations

Alterations in the Characteristics of Sugar Uptake by Mouse Cells Transformed by Murine Sarcoma Viruses<xref ref-type="fn" rid="FN2">2</xref>

1969 • 115 citations

Isolation of a Plasma‐Membrane Subfraction from Rat Liver Containing an Insulin‐Sensitive Cyclic‐AMP Phosphodiesterase

1972 • 113 citations

The nuclear envelope. The major site of insulin binding in rat liver nuclei.

1978 • 112 citations

The relationship between the transport of glucose and cations across cell membranes in isolated tissues. VI. The effect of insulin, ouabain, and metabolic inhibitors on the transport of 3-O-methylglucose and glucose in rat soleus muscles

1971 • 110 citations

Studies on the Metabolism of Adipose Tissue. XIII. The Effect of Anaerobic Conditions and Dietary Regime on the Response to Insulin and Epinephrine^*

1963 • 110 citations

Tunicamycin‐mediated depletion of insulin receptors in 3T3‐L1 adipocytes

1979 • 110 citations

The Kinetics of Selective Biological Transport

1968 • 110 citations

Water-Soluble Insulin Receptors from Human Lymphocytes

1972 • 108 citations

Appraisal of the extrapancreatic actions of sulfonylureas.

1969 • 107 citations

The Effect of Solubilization on the Properties of the Insulin Receptor of Human Placental Membranes*

1978 • 106 citations

Specificity of the effects of cytochalasin B on transport and motile processes.

1978 • 106 citations

Endocrine control in neoplasia

1978 • 106 citations

Insulin receptor defect in insulin resistance: Studies in the obese-hyperglycemic mouse

1972 • 105 citations

Thymic Lymphocytes in Obese (ob/ob) Mice

1974 • 104 citations

Gross structural changes in isolated liver cell plasma membranes upon binding of insulin

1979 • 102 citations

Insulin receptor: Interaction with nonreceptor glycoprotein from liver cell membranes

1978 • 100 citations

Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance

1973 • 99 citations

Evidence for a carrier conformational change associated with sugar transport in erythrocytes

1971 • 99 citations

Immunoprecipitation of the Insulin Receptor: A Sensitive Assay for Receptor Antibodies and a Specific Technique for Receptor Purification*

1979 • 97 citations

Insulin-induced dissociation of its receptor into subunits: Possible molecular concomitant of negative cooperativity

1976 • 96 citations

Insulin binding and insulin response of adipocytes from rats adapted to fat feeding

1976 • 95 citations

Membrane effects of tumor promoters: Stimulation of sugar uptake in mammalian cell cultures

1979 • 95 citations

Sugar Transport in Chick Embryo Fibroblasts

1974 • 95 citations

Cellular binding sites for insulin in rat liver

1975 • 94 citations

The relationship between the transport of glucose and cations across cell membranes in isolated tissues. IX. The role of cellular calcium in the activation of the glucose transport system in rat soleus muscle

1975 • 94 citations

Relationship between Degree of Iodination of Insulin and Its Biological, Electrophoretic, and Immunochemical Properties

1964 • 93 citations

Site of action of adrenocorticotropic hormone (ACTH) in adrenal cell cultures

1968 • 93 citations

Electron Microscopic Demonstration of Insulin Receptors on Adipocyte Plasma Membranes Utilizing a Ferritin-Insulin Conjugate

1974 • 90 citations

Eigenschaften eines asymmetrischen carrier-modells für den zuckertransport am menschlichen erythrozyten

1971 • 89 citations

Phytohaemagglutinin stimulation of rat thymus lymphocyte glycolysis

1976 • 88 citations

Stimulation of RNA synthesis in isolated mammary cells by insulin and prolactin bound to Sepharose

1970 • 85 citations

Intracellular localization of 125I-labeled insulin in hepatocytes from intact rat liver.

1979 • 84 citations

Calcium Binding by Skeletal Muscle Sarcolemma

1973 • 83 citations

Association of cell surface receptors for melanotropin with the Golgi region in mouse melanoma cells.

1976 • 82 citations

Mechanism of Action of Insulin

1974 • 81 citations

Twenty-four-hour preoperative endocrine profiles in women with benign and malignant breast disease.

1977 • 81 citations

Magnesium deprivation reproduces the coordinate effects of serum removal or cortisol addition on transport and metabolism in chick embryo fibroblasts

1976 • 81 citations

Ultrastructural localization of insulin receptors on adipocytes.

1975 • 81 citations

Mediated (Nonactive) Transport of Glucose in Mammalian Cells and its Regulation

1968 • 78 citations

NATIONAL POLICIES AND NATIONAL EXPERTS Basic Requirements in Developing Countries

1981 • 77 citations

Sugar Transport in Chick Embryo Fibroblasts

1974 • 77 citations

MODE OF INSULIN ACTION

1975 • 76 citations

Ability of insulin to increase calcium binding by adipocyte plasma membranes.

1976 • 76 citations

The Kinetics of Selective Biological Transport

1968 • 76 citations

Insulin binding to solubilized material from fat cell membranes: Evidence for two binding species

1978 • 75 citations

Receptors for insulin and epidermal growth factor: Relation to synthesis of DNA in cultured rabbit lens epithelium

1975 • 75 citations

Intracellular binding sites for insulin are immunologically distinct from those on the plasma membrane

1977 • 75 citations

POTENTIATION OF INSULIN ACTION: A PROBABLE MECHANISM FOR THE ANTI-DIABETIC ACTION OF SULFONYLUREA DRUGS

1977 • 75 citations

Membrane bound and cellular cationic changes associated with insulin stimulation of cultured cells

1978 • 74 citations

The Role of Calcium in Insulin Action

1975 • 74 citations

THE EFFECT OF A HIGH-FAT DIET ON GLUCOSE, INSULIN SENSITIVITY AND PLASMA INSULIN IN RATS

1968 • 74 citations

Appraisal of the Extrapancreatic Actions of Sulfonylureas

1969 • 73 citations

Stimulation of 2-deoxyglucose uptake in growth-inhibited BALB/c 3T3 and revertant SV40-transformed 3T3 cells

1974 • 73 citations

Biological potency and binding affinity of monoiodoinsulin with iodine in tyrosine A14 or tyrosine A19

1979 • 71 citations

Transport of sugars in chick-embryo fibroblasts. Evidence for a low-affinity system and a high-affinity system for glucose transport

1976 • 70 citations

The relationship between the transport of glucose and cations across cell membranes in isolated tissues

1969 • 70 citations

Autoantibodies to the Insulin Receptor

1977 • 69 citations

[127-I]- or carrier-free [125-I]monoiodoinsulin

1975 • 69 citations

THE INTRACELLULAR LOCALIZATION OF LABELED THYROXINE AND LABELED INSULIN IN MAMMALIAN LIVER¹

1954 • 69 citations

A Medical Treatment for Gallstones?

1972 • 67 citations

Regulation of the Transport and Metabolism of Amino Acids in Isolated Fat Cells

1970 • 66 citations

Does Insulin Need a Second Messenger?

1977 • 66 citations

A diploid rat liver cell culture

1974 • 65 citations

The Involvement of Cyclic AMP in the Hormonal Regulation of Protein Synthesis in Rat Adipocytes1

1972 • 64 citations

Sensitivity of the adipocyte D-glucose transport system to membrane fluidity in reconstituted vesicles.

1979 • 64 citations

Cell shape and hexose transport in normal and virus‐transformed cells in culture

1977 • 64 citations

Insulin binding sites on rat liver nuclear membranes: Biochemical and immunofluorescent studies

1978 • 63 citations

Cell surface receptors for insulin and human growth hormone. Effect of microtubule and microfilament modifiers.

1976 • 63 citations

Studies on serum lipids, insulin, and glucagon and on muscle triglyceride in rats adapted to high-fat and high-carbohydrate diets.

1978 • 63 citations

Insulin receptors and the site of action of insulin

1978 • 62 citations

Molecular Structural Factors in Competitive Inhibition of Sugar Transport

1959 • 62 citations

Insulin Receptor of Fat Cells in Insulin-Resistant Metabolic States

1972 • 62 citations

Trypsin treatment of adipocytes: Effect on sensitivity to insulin

1972 • 62 citations

Subunit structure of the insulin receptor of the human lymphocyte

1980 • 61 citations

Receptors in pharmacology

1978 • 61 citations

A comparison of insulin binding by liver plasma membranes of rats fed a high glucose diet or a high fat diet

1977 • 61 citations

Uptake patterns and transport enhancements in cultures of hamster cells deprived of carbohydrates

1975 • 60 citations

Deoxyglucose and 3‐O‐methylglucose transport in untreated and ATP‐depleted novikoff rat hepatoma cells. Analysis by a rapid kinetic technique, relationship to phosphorylation and effects of inhibitors

1978 • 58 citations

Effect of 3':5'-cyclic AMP on glucose transport in rat adipocytes.

1976 • 57 citations

Regulation of Sugar Transport in Avian Erythrocytes

1969 • 56 citations

Polypeptides of the nuclear envelope

1976 • 56 citations

Growth- and Density-Dependent Inhibition of Deoxyglucose Transport in Balb 3T3 Cells and Its Absence in Cells Transformed by Murine Sarcoma Virus

1973 • 56 citations

Insulin and epidermal growth factor-urogastrone: Affinity crosslinking to specific binding sites in rat liver membranes

1978 • 55 citations

Deoxyglucose transport by uninfected, murihe sarcoma virus-transformed, and murine leukemia virus-infected mouse cells

1973 • 54 citations

Insulin-Sepharose and the Dynamics of Insulin Action

1971 • 54 citations

Effect of temperature and of cytochalasin B and persantin on the nonmediated permeation of non-electrolytes into cultured Novikoff rat hepatoma cells.

1977 • 54 citations

Characterization of (3H)cytochalasin B binding to the fat cell plasma membrane.

1976 • 53 citations

Effect of insulin on the phosphorylation of adipose tissue protein

1974 • 53 citations

Amelioration of insulin resistance in obese mice

1971 • 52 citations

Contact-inhibited revertant cell lines isolated from SV40-transformed cells

1973 • 52 citations

Effect of calcium, insulin and growth hormone on membrane fluidity. A spin label study of rat adipocyte and human erythrocyte ghosts

1980 • 51 citations

Inhibition of glucagon‐stimulated adenyl cyclase by insulin

1971 • 51 citations

Transport of D‐allose by isolated fat‐cells: An effect of adenosine triphosphate on insulin stimulated transport

1976 • 49 citations

Hormone receptors 7. Characteristics of insulin receptors in a new line of cloned neonatal rat hepatocytes

1978 • 49 citations

Structural Features of Steroids Which Initiate Proliferation of Density-inhibited 3T3 Mouse Fibroblasts

1974 • 49 citations

INHIBITION OF DNA SYNTHESIS IN CHICK EMBRYO CULTURES BY DEPRIVATION OF EITHER SERUM OR ZINC

1973 • 48 citations

Two Distinct Types of Enhancement of Galactose Uptake into Hamster Cells: Tumor-Virus Transformation and Hexose Starvation

1973 • 47 citations

In vivo regulation of cell surface and intracellular insulin binding sites by insulin.

1978 • 47 citations

Activation of 3-O-methyl-glucose transport in rat thymus lymphocytes by concanavalin A temperature and calcium ion dependence and sensitivity to puromycin but not to cycloheximide

1977 • 46 citations

Insulin and Sepharose-Insulin Effects on Tyrosine Transaminase Levels in Cultured Rat Liver Cells

1973 • 46 citations

Secretion of and Sensitivity to Insulin in Obese Rats Fed a High-Fat Diet

1969 • 46 citations

Regulation of Hepatic Glycogen Synthetase

1971 • 46 citations

Digestion of insulin receptors with proteolytic and glycosidic enzymes-effects on purified and membrane-associated receptor subunits

1980 • 46 citations

Insulin receptors in murine mammary cells: Comparison in pregnant and nonpregnant animals

1974 • 45 citations

Endocrine Function of the Pancreas

1974 • 45 citations

Changes in the uptake of 2‐deoxy‐D‐glucose in Balb/3T3 cells chemically transformed in culture

1974 • 44 citations

Current status of the thiol redox model for the regulation of hexose transport by insulin

1976 • 44 citations

Stimulation of hexose transport in cultured human skin fibroblasts by insulin

1979 • 44 citations

Effects of hypertonicity on resting and contracting frog skeletal muscles

1974 • 44 citations

REgulation of insulin binding to isolated hepatocytes: correction for bound hormone fragments linearizes Scatchard plots.

1980 • 43 citations

Degradation, receptor binding affinity, and potency of insulin from the Atlantic hagfish (Myxine glutinosa) determined in isolated rat fat cells.

1977 • 43 citations

Effect of Iodination on the Biological Activity of Insulin

1964 • 43 citations

The Role of Calcium in Insulin Action

1975 • 42 citations

Permeability of bimolecular membranes made from lipid extracts of human red cell ghosts to sugars

1971 • 42 citations

Different regulation of insulin receptors in intracellular (Golgi) and plasma membranes from livers of obese and lean mice.

1978 • 42 citations

Regulation of plasma membrane protein phosphorylation in two mammalian cell types

1976 • 41 citations

Characterization of the Insulin Receptor and Insulin-Degrading Activity from Human Lymphocytes by Quantitative Polyacrylamide Gel Electrophoresis*

1980 • 41 citations

Influence of dietary fat and carbohydrate on the metabolism of adipocytes of different size in the rat

1974 • 41 citations

Cell Membrane Receptors for Polypeptide Hormones: Applications to the Study of Disease States in Mice and Men

1975 • 40 citations

Density‐dependent and adaptive regulation of glucose transport in primary cell cultures of the R3230AC rat mammary adenocarcinoma

1980 • 40 citations

Preparation of inverted plasma membrane vesicles from isolated adipocytes

1973 • 40 citations

Rapid loss of ATP by tumor cells deprived of glucose: Contrast to normal cells

1978 • 39 citations

Studies on the mechanism of insulin action: Basic concepts and clinical implications

1977 • 39 citations

The stimulus-secretion coupling of glucose-induced insulin release—XVII

1975 • 39 citations

Paradoxical effects of cycloheximide and cytochalasin B on hamster cell hexose uptake.

1976 • 39 citations

Hexose transport regulation in cultured hamster cells

1977 • 37 citations

Kinetics of 2-deoxy-d-glucose transport into cultured mouse neuroblastoma cells

1976 • 37 citations

2‐Amino‐isobutyric acid and 3‐0‐methyl‐D‐glucose transport in 3T3, SV40‐transformed 3T3 and revertant cell lines

1978 • 37 citations

Saturable and nonsaturable hexose uptake in cultured human skin fibroblasts

1978 • 36 citations

Binding of Insulin to Thymocytes from Suckling and Hypophysectomized Rats: Evidence for Two Mechanisms Regulating Insulin Sensitivity

1975 • 36 citations

Binding of [3H]cytochalasin B and its relationship to inhibition of hexose transport in Novkoff rat hepatoma cells.

1977 • 36 citations

Preparation of solubilized insulin receptors from human lymphocytes

1972 • 35 citations

“Carrier activation” and glucose transport in Chinese hamster fibroblasts

1978 • 35 citations

A diploid rat liver cell culture

1975 • 35 citations

Membrane effects of cytochalasin B. Competitive inhibition of facilitated diffusion processes in rat hepatoma cells and other cell lines and effect on formation of functional transport sites

1975 • 34 citations

Virus-Specified Changes in the Sugar-Transport Kinetics of Rat Embryo Cells Infected With Murine Sarcoma Virus<xref ref-type="fn" rid="FN2">2</xref>

1970 • 33 citations

Evidence Supporting a Two-Receptor Model for Insulin Binding by Cultured Embryonic Heart Cells*

1980 • 33 citations

Biological Activity of Insulin-Sepharose?

1973 • 32 citations

Dissociation by cytochalasin B of movement, DNA synthesis and transport in 3T3 cells

1975 • 32 citations

Density-dependent regulation of growth of BSC-1 cells in cell culture: Control of growth by low molecular weight nutrients

1978 • 32 citations

A new approach in the kinetics of biological transport the potential of reversible inhibition studies

1978 • 32 citations

Effect of externally added ATP on glucose uptake by isolated rat soleus muscle

1970 • 31 citations

New Theory for Glucose Transport Across Membranes

1971 • 31 citations

Transport Alterations in Virus-Transformed Cells1

2015 • 31 citations

Does insulin need a second messenger?

1977 • 30 citations

A Soluble Super-Active Form of Insulin

1974 • 30 citations

Hormone receptor interactions at the cell membrane.

1978 • 30 citations

Insulin Action at the Molecular Level: Facts and Speculations

1972 • 29 citations

Insulin receptors in 3T3 fibroblasts

1977 • 29 citations

Subcellular distribution of intraportally injected 125I-labeled insulin in rat liver

1979 • 28 citations

Properties and partial purification of the detergent-solubilized insulin receptor A demonstration of negative cooperativity in micellar solution

1978 • 28 citations

Identity of nuclear membrane and non-histone nuclear proteins

1976 • 28 citations

Proliferation of endoplasmic reticulum with its enzyme, UDP-glucuronyltransferase, in chick embryo liver during culture. Effects of phenobarbital.

1976 • 27 citations

Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic amp levels and rate of transport of nucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells

1975 • 27 citations

Regulatory interrelationships for insulin and estrogen action in mammary tumors.

1978 • 27 citations

Action of insulin analogues on cultured human fibroblasts reflects biological potency

1976 • 26 citations

Modulation of 125I-insulin degradation by receptors in liver plasma membranes

1977 • 26 citations

Effects of insulin on insulin-binding components extracted from rat fat cell membranes

1979 • 26 citations

Glucose transport by trypsin-treated red blood cell ghosts

1973 • 26 citations

Identification and characterization of the insulin receptor in the R3230AC mammary adenocarcinoma of the rat.

1976 • 26 citations

Hormone control of plasma membrane oxidation—reduction reactions

1978 • 25 citations

Regulation of sugar transport in chick embryo fibroblasts and in fibroblasts transformed by a temperature‐sensitive mutant of the rous sarcoma virus

1976 • 25 citations

Glucose transport characteristics of quiescent thymocytes.

1978 • 25 citations

Effects of Carbohydrate-free Diets on the Insulin-Carbohydrate Relationships in Rats

1975 • 25 citations

PREPARATION AND CHARACTERIZATION OF MONOIODOINSULIN

1974 • 25 citations

Relationship between insulin and estrogen binding to growth response in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.

1978 • 25 citations

Hexose uptake and control of fibroblast proliferation

1977 • 25 citations

Dynamics of Insulin Action on Mammary Epithelium

1972 • 25 citations

Influence of hormones on NADH-dehydrogenase in mouse liver plasma membrane

1978 • 25 citations

The action of the cytochalasins at the subcellular level. I. Effects and binding of cytochalasin B in cells of a line derived from a rat mammary adenocarcinoma and in rat erythrocytes

1975 • 24 citations

Transport enhancement and reversal: Glucose and 3‐O‐methyl glucose

1977 • 24 citations

The uptake and degradation of growth hormone fragments by isolated rat hepatocytes.

1978 • 24 citations

Induction of tyrosine aminotransferase by Sepharose-insulin

1974 • 23 citations

Regulation of glucose carriers in chick fibroblasts

1977 • 22 citations

THE MECHANISM OF SUGAR TRANSFER ACROSS ERYTHROCYTE MEMBRANES

1972 • 22 citations

Regulation of glucose uptake in muscle. IV. The effect of hypophysectomy on glucose transport, phosphorylation, and insulin sensitivity in the isolated, perfused heart.

1961 • 21 citations

The Binding and Degradation of Insulin by Rat Liver Membranes: Demonstration of Three Distinct Insulin-Binding Components in Detergent-Solubilized Material from Liver Plasma Membrane*

1980 • 21 citations

Effect of insulin to decrease glucose transport in dissociated cells from the R3230AC mammary adenocarcinoma of diabetic rats

1976 • 20 citations

Saturable and nonsaturable process of sugar uptake: Effect of oncogenic transformation in transport and uptake of nutrients

1976 • 20 citations

Characteristics of the solubilized insulin receptor of human placenta

1978 • 20 citations

On the stimulation of rat thymocyte 3‐0‐methyl‐glucose transport by mitogenic stimuli

1978 • 20 citations

A study of the biological activity of iodinated insulin

1961 • 20 citations

Identification of photoaffinity labeled insulin receptor proteins by linear polyacrylamide gradient gel electrophoresis under non‐denaturing conditions

1980 • 20 citations

Insulin-stimulated plasma membranes from rat adipocytes: their physiological and physicochemical properties

1972 • 20 citations

Insulin and glucose 6-phosphate stimulation of Ca2+ uptake by skinned muscle fibers.

1980 • 20 citations

Regulation of Glucose Uptake in Muscle

1961 • 19 citations

Stereospecific hexose transport by membrane vesicles from mouse fibroblasts: Membrane vesicles retain increased hexose transport associated with viral transformation

1979 • 19 citations

Control of glucose transport in adipose tissue of the rat: Role of insulin, ATP, and intracellular metabolites

1978 • 19 citations

Involvement of membrane sulfhydryls in the activation and maintenance of nutrient transport in chick embryo fibroblasts

1977 • 19 citations

The Role of Calcium Ion in Epinephrine Activation of Lipolysis

1976 • 19 citations

Distribution of insulin receptors among mouse liver endomembranes

1979 • 18 citations

Effects in adipocytes of diamide on GSH levels, glucose uptake and cell integrity

1978 • 17 citations

In vitro bioactivity of insulin analogues: Lipogenic and anti-lipolytic potency and their interaction with the effect of native insulin

1978 • 16 citations

Comparative studies of glucose‐fed and glucose‐starved hamster cell cultures: Responses in galactose metabolism

1977 • 16 citations

Isolation from normal and Rous sarcoma virus-transformed chicken fibroblasts of a factor that binds glucose and stimulates its transport.

1977 • 16 citations

An Effect of Fluorescent Probes and of Insulin on the Structure of Adipocyte Membranes

1978 • 15 citations

Retention of insulin-stimulated D-glucose transport activity by adipocyte plasma membranes following extraction of extrinsic proteins

1978 • 14 citations

Glucose-regulated membrane properties of untransformed and virus-transformed BHK21 cells

1979 • 13 citations

Preparation and properties of (monoiodotyrosine)-insulin

1972 • 13 citations

Insulin receptors and functions in normal and spontaneously transformed cloned rat hepatocytes

1979 • 12 citations

Insulin binding and glucose transport in the R3230AC mammary adenocarcinoma

1976 • 12 citations

Onset and reversibility of changes in secretory function and composition of isolated rat pancreatic islets following long-term administration of high or low tolbutamide doses

1977 • 11 citations

Insulin receptors in transformed fibroblasts and in adipocytes: a comparative study

1979 • 10 citations

Ribonucleotide depletion in glucose-deprived tumor cells — The role of RNA synthesis

1979 • 8 citations

Glucose binding and transport proteins extracted from fast-growing chicken fibroblasts

1978 • 8 citations

Resistance of the intact and reconstituted adipocyte hexose transport system to irreversible inhibition by sulfhydryl and amino reagents

1978 • 8 citations

Alteration of hexose transport in avian erythrocytes by vinblastine and colchicine

1978 • 8 citations

Effects of Glucose Starvation on Normal and Rous Sarcoma Virus-Transformed Chick Cells<xref ref-type="fn" rid="fn2">2</xref>

1975 • 7 citations

Hexose uptake enhancing factor released from rous sarcoma cells

1980 • 7 citations

Paradoxical effects of 17β-estradiol on glucose transport in primary cell cultures of a rat mammary tumor

1980 • 7 citations

Degradation, Receptor Binding Affinity and Biological Potency of Monoiodoinsulin in Isolated Rat Fat Cells

1977 • 6 citations

Pathophysiology of the insulin receptor

1979 • 4 citations