Onset and reversibility of changes in secretory function and composition of isolated rat pancreatic islets following long-term administration of high or low tolbutamide doses

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1967 • 2,783 citations

Über die radioimmunologische Bestimmung von Insulin im Blut

1965 • 180 citations

Adenylate Cyclase in Islets of Langerhans

1973 • 178 citations

Effect of Chlorpropamide on Serum Glucose and Immunoreactive Insulin Concentrations in Patients with Maturity-onset Diabetes Mellitus

1967 • 150 citations

EFFECTS OF PREGNANCY IN THE RAT ON THE SIZE AND INSULIN SECRETORY RESPONSE OF THE ISLETS OF LANGERHANS

1972 • 146 citations

Glucagon Receptors in β-Cells

1972 • 145 citations

Effect of Chronic Sulfonylurea Therapy on Plasma Insulin and Proinsulin Levels

1972 • 119 citations

Appraisal of the extrapancreatic actions of sulfonylureas.

1969 • 107 citations

Effects of L‐leucine and α‐ketoisocaproic acid upon insulin secretion and metabolism of isolated pancreatic islets

1972 • 86 citations

The Dual Function of Glucose in Islets of Langerhans

1971 • 83 citations

The Pattern of Response of Plasma Insulin and Glucose to Meals and Fasting During Chlorpropamide Therapy

1968 • 81 citations

In vitro stimulation of insulin release by non-metabolizable, transport-specific amino acids

1971 • 75 citations

THE STIMULATION OF INSULIN RELEASE BY ESSENTIAL AMINO ACIDS FROM RABBIT PANCREAS IN VITRO

1970 • 69 citations

The effect of glucose on insulin biosynthesis by isolated islets of langerhans of the rat

1970 • 68 citations

The role of adenosine 3′:5′-cyclic monophosphate in the regulation of insulin release. Properties of islet-cell adenosine 3′:5′-cyclic monophosphate phosphodiesterase

1972 • 66 citations

Behavior in the Rat of a Transport-specific, Bicyclic Amino Acid

1969 • 65 citations

Inhibition of Cyclic 3′,5′-AMP Phosphodiesterase in Islet Cells and Other Tissues by Tolbutamide

1971 • 61 citations

An inhibitory effect of tolbutamide and glibenclamide (glyburide) on the pancreatic islets of normal animals

1974 • 58 citations

The effects of long-term acetohexamide treatment on pancreatic islet cell function in maturity-onset diabetes

1966 • 53 citations

A Comparison of Leucine- and Acetoacetate-induced Hypoglycemia in Man*

1964 • 52 citations

Morphologic Changes Associated with Sulfonylurea Therapy

1963 • 50 citations

Some effects of BZ-55 (carbutamide) on the growth of the islets of Langerhans.

1956 • 34 citations

Further Characterization of os Mutation of Mouse β-Glucuronidase Locus

1971 • 31 citations

The effect of tolbutamide and glibenclamide on the incorporation of [³H]leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets

1972 • 30 citations

Appraisal of the extrapancreatic actions of sulfonylureas

1969 • 26 citations

Ultrastructure of ?-cells during the dynamic response to glucose and tolbutamide in vitro

1970 • 23 citations

Reduction in the Activity of the Pancreatic Islets Induced in Normal Rodents by Prolonged Treatment with Derivatives of Sulfonylurea

1970 • 23 citations

Cytochalasin B: Inhibition of glucose-induced insulin release from isolated rat pancreatic islets

1974 • 21 citations

Glucose-mediated Insulin Release: 3′,5′ cAMP Phosphodiesterase

1973 • 21 citations

[Morphological findings on the mode of action of oral antidiabetics].

1957 • 19 citations

Zur Isolierung Langerhansscher Inseln aus Rattenpankreas

1970 • 17 citations

B CELL HYPERFUNCTION AFTER LONG-TERM SULFONYLUREA TREATMENT.

1964 • 17 citations

Tolbutamide-induced changes of the DNA, protein and insulin content and the secretory activity of isolated rat pancreatic islets

1975 • 16 citations

[Pharmacological comparison between tolbutamide and two second generation hypoglycemic sulfonylureas (glibenclamide and glisoxepide)].

1973 • 14 citations

Pharmacological comparison between tolbutamide and two second generation hypoglycemic sulfonylureas (Glibenclamide and glisoxepide)

1973 • 14 citations

[Physiological and pharmacological aspects of the central role of the pancreas in the mode of action of hypoglycemic sulfonamides].

1969 • 13 citations

5′-Guanylylimidodiphosphate: A modulator of glucagon-induced insulin release from isolated rat pancreatic islets

1975 • 12 citations

THE STIMULATORY EFFECT ON INSULIN SECRETION IN LONG-TERM TOLBUTAMIDE TREATMENT

1972 • 7 citations

[Current views on the mode of action of hypoglycemic sulfonamides].

1969 • 6 citations

Effect of the daily injection of tolbutamide into pregnant rats on the pancreatic insulin content of their offspring

1973 • 4 citations