Evidence Supporting a Two-Receptor Model for Insulin Binding by Cultured Embryonic Heart Cells*

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

A graphic method for the determination and presentation of binding parameters in a complex system

1967 • 1,524 citations

Insulin interactions with its receptors: Experimental evidence for negative cooperativity

1973 • 717 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Principles of enzyme kinetics

1976 • 468 citations

Isolation and characterization of a new pancreatic polypeptide hormone.

1975 • 441 citations

ANTIBODY-SUPPRESSIBLE AND NONSUPPRESSIBLE INSULIN-LIKE ACTIVITIES IN HUMAN SERUM AND THEIR PHYSIOLOGIC SIGNIFICANCE. AN INSULIN ASSAY WITH ADIPOSE TISSUE OF INCREASED PRECISION AND SPECIFICITY*

1963 • 399 citations

Quantitative Aspects of the Insulin-Receptor Interaction in Liver Plasma Membranes

1974 • 378 citations

Insulin-like growth factor: a model for tertiary structure accounting for immunoreactivity and receptor binding.

1978 • 282 citations

Regulation of spontaneous activity and growth of embryonic chick heart cells in tissue culture

1967 • 280 citations

Isolation and Characterization of Chicken Insulin

1968 • 278 citations

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

1978 • 223 citations

Intracellular Translocation of Iodine-125-Labeled Insulin: Direct Demonstration in Isolated Hepatocytes

1978 • 220 citations

Insulin binding to the human lymphocyte receptor. Evaluation of the negative cooperativity model.

1977 • 205 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Determination of DNA and RNA in homogenized cells and tissues by surface fluorometry

1972 • 182 citations

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography.

1978 • 171 citations

Purification and Characterization of Multiplication‐Stimulating Activity

1980 • 171 citations

The Insulin Receptor in Vertebrates Is Functionally More Conserved during Evolution than Insulin Itself

1979 • 164 citations

Characterization of the binding of multiplication-stimulating activity to a receptor for growth polypeptides in chick embryo fibroblasts.

1977 • 153 citations

Entry of Insulin Into Human Cultured Lymphocytes: Electron Microscope Autoradiographic Analysis

1978 • 135 citations

The potassium-sensitivity of isolated embryonic heart cells increases with development

1970 • 107 citations

On the development of amino acid transport systems.

1973 • 100 citations

Insulin binding and insulin response of adipocytes from rats adapted to fat feeding

1976 • 95 citations

Decreased Binding of Insulin to Its Receptor in Patients with Congenital Generalized Lipodystrophy

1977 • 93 citations

Purified Human Somatomedin A and Rat Multiplication Stimulating Activity

1978 • 83 citations

The natural occurrence of insulin receptors in groups on adipocyte plasma membranes as demonstrated with monomeric ferritin‐insulin

1977 • 69 citations

Amino acid transport by aggregates of cultured chicken heart cells. Effect of insulin.

1975 • 64 citations

Insulin Binding to Adipocytes: Evidence for Functionally Distinct Receptors

1978 • 63 citations

Effects of multiplication stimulating activity (MSA) on AIB transport into myoblast and myotube cultures

1977 • 46 citations

Effect of Cytochalasin B and D on Groups of Insulin Receptors and on Insulin Action in Rat Adipocytes

1979 • 44 citations

Proinsulin Binds to a Growth Peptide Receptor and Stimulates DNA Synthesis in Chick Embryo Fibroblasts¹

1977 • 44 citations

Measurement of DNA in isolated granulocytes by the ethidium technique

1973 • 36 citations

Somatomedins and related growth factors

1977 • 30 citations

Involvement of glycoconjugates in insulin-receptor interactions Studies in liver plasma membranes of control and diabetic mice

1978 • 30 citations

Relationship of Insulin Binding to Amino Acid Transport by Cultured 14-Day Embryonic Chick Heart Cells*

1979 • 28 citations

Co-operative response of oligomeric protein receptors coupled to non-co-operative ligand binding

1975 • 25 citations

Further Evidence for Functional Heterogeneity of Adipocyte Insulin Receptors*

1979 • 22 citations

Effect of calcium on [125I]insulin binding to rat adipocytes

1978 • 20 citations

Developmental control of 2-aminoisobutyric acid transport by 7- and 14-day chick heart cell aggregates

1978 • 14 citations

Insulin receptors in fat cells: relationship between binding and activation.

1975 • 5 citations