Cyclic Adenosine Monophosphate-dependent Phosphorylation of Specific Fat Cell Membrane Proteins by an Endogenous Membrane-bound Protein Kinase

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis

1969 • 20,498 citations

Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane

1971 • 8,619 citations

A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter

1960 • 7,610 citations

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

A simple method for the preparation of 32P-labelled adenosine triphosphate of high specific activity

1964 • 1,880 citations

Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells

1971 • 838 citations

CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES, IV. WIDESPREAD OCCURRENCE OF ADENOSINE 3′,5′-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE IN VARIOUS TISSUES AND PHYLA OF THE ANIMAL KINGDOM

1969 • 775 citations

Effects of Lipolytic and Antilipolytic Substances on Adenosine 3′,5′-Monophosphate Levels in Isolated Fat Cells

1968 • 555 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 519 citations

Protein Kinases* *Support of the National Institutes of Arthritis and Metabolic Diseases, NIH, U. S. Public Health Service (AM 12842), the Muscular Dystrophy Association of America, and the American Heart Association is acknowledged.

1972 • 416 citations

A procedure for measurement of distribution spaces in isolated fat cells

1972 • 366 citations

An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase

1970 • 346 citations

Regulation of Endogenous Phosphorylation of Specific Proteins in Synaptic Membrane Fractions from Rat Brain by Adenosine 3′:5′-Monophosphate

1973 • 341 citations

Effect of Insulin on Adenosine 3‘,5‘-Monophosphate in the Rat Epididymal Fat Pad

1966 • 340 citations

Role of Adenosine 3′,5′-Monophosphate in the Effects of Insulin and Anti-insulin Serum on Liver Metabolism

1968 • 328 citations

An Adenosine 3′,5′-Monophosphate-dependent Protein Kinase from Escherichia coli

1969 • 266 citations

Cyclic Adenosine 3′,5′-Monophosphate-dependent Protein Kinase of Human Erythrocyte Membranes

1972 • 249 citations

An Effect of Insulin on Cyclic Adenosine 3′:5′-Monophosphate Phosphodiesterase Activity in Fat Cells

1973 • 245 citations

Studies on Rat Adipose Tissue in Vitro

1960 • 244 citations

Modulation of Adenylate Cyclase Activity in Liver and Fat Cell Membranes by Insulin

1972 • 243 citations

Interaction of wheat germ agglutinin and concanavalin A with isolated fat cells

1973 • 235 citations

Guanosine 3′:5′-Cyclic Monophosphate and the Action of Insulin and Acetylcholine

1973 • 232 citations

Properties of the Insulin Receptor of Isolated Fat Cell Membranes

1971 • 227 citations

Phosphorylation of an Endogenous Membrane Protein by an Endogenous, Membrane-associated Cyclic Adenosine 3′,5′-Monophosphate-dependent Protein Kinase in Human Erythrocyte Ghosts

1972 • 224 citations

Adipose Tissue. Regulation and Metabolic Functions.

1971 • 217 citations

Subcellular Distribution of Adenosine 3',5'-Monophosphate-dependent Protein Kinase in Rat Brain

1971 • 208 citations

THE ROLE OF CYCLIC AMP IN THE INTERACTION OF GLUCAGON AND INSULIN IN THE CONTROL OF LIVER METABOLISM*

1971 • 205 citations

Effects of Lipolytic and Antilipolytic Agents on Cyclic 3',5'-Adenosine Monophosphate in Fat Cells

1971 • 199 citations

The effect of insulin upon glucose metabolism by adipose cells of different size

1971 • 185 citations

Adenylate Cyclase in Islets of Langerhans

1973 • 178 citations

Adenosine 3′,5-Monophosphatedependent Phosphorylation of a Specific Protein in Synaptic Membrane Fractions from Rat Cerebrum

1972 • 177 citations

ROLE OF CYCLIC-3′,5′-AMP IN THE RESPONSE OF ADIPOSE TISSUE TO INSULIN

1966 • 165 citations

Adenosine Triphosphate-dependent Inhibition of Insulin-stimulated Glucose Transport in Fat Cells

1974 • 135 citations

Protein Kinases: Aspects of Their Regulation and Diversity

1973 • 129 citations

Cyclic Adenosine 3′,5′-Monophosphate-stimulated Protein Kinase and a Substrate Associated with Cardiac Sarcoplasmic Reticulum

1973 • 128 citations

Regulation of Phosphorylation of a Specific Protein in Toad-Bladder Membrane by Antidiuretic Hormone and Cyclic AMP, and Its Possible Relationship to Membrane Permeability Changes

1973 • 125 citations

Erythrocyte Protein Phosphorylation

1973 • 122 citations

The role of cyclic AMP in the phosphorylation of proteins in human erythrocyte membranes

1973 • 118 citations

Effects of insulin treatment on muscle 3′,5′-cyclic adenylate levels in vivo and in vitro

1967 • 110 citations

Insulin action on the adenyl cyclase system: Antagonism to activation by lipolytic hormones

1972 • 109 citations

The Uptake and Inactivation of Native Insulin by Isolated Fat Cells

1968 • 99 citations

Insulin Insensitivity of Large Fat Cells

1972 • 95 citations

Protein kinase activity in membrane preparations from ox brain. Stimulation of intrinsic activity by adenosine 3′:5′-cyclic monophosphate

1973 • 93 citations

Phosphorylation of myelin basic protein by an adenosine 3′:5′-cyclic monophosphate-dependent protein kinase (Short Communication)

1973 • 90 citations

Activation by Adenosine 3′:5′-Monophosphate of a Membrane-Bound Phosphoprotein Phosphatase from Toad Bladder

1973 • 87 citations

Hormone-dependent Phosphorylation of Ribosomal and Plasma Membrane Proteins in Mouse Mammary Gland in Vitro

1972 • 85 citations

Adenyl cyclase activity in particles from fat cells

1969 • 84 citations

Cyclic AMP—Dependent Reversible Phosphorylation of Renal Medullary Plasma Membrane Protein

1972 • 77 citations

Effect of insulin and growth hormone on rat liver cyclic nucleotide phosphodiesterase

1973 • 76 citations

Nucleotide inhibition of adenyl cyclase activity in fat cell membranes

1969 • 75 citations

Basal and hormone-stimulated adenylate cyclase in liver plasma membranes: Measurement by radioimmunoassay of cyclic AMP

1973 • 75 citations

Activation of guanyl cyclase and adenyl cyclase by secretin

1973 • 73 citations

Effect of Insulin on the Growth Pattern and Adenylate Cyclase Activity of BHK Fibroblasts

1973 • 72 citations

Adenylate Cyclase and Insulin Action

1972 • 72 citations

Studies on the metabolism of the protozoa. 4. Metabolism of the parasitic flagellate Strigomonas oncopelti

1955 • 71 citations

Comparative studies on the physiology of adipose tissue.

1967 • 68 citations

Adenylate Cyclase Activity in Neurospora crassa

1973 • 67 citations

The Involvement of Cyclic AMP in the Hormonal Regulation of Protein Synthesis in Rat Adipocytes1

1972 • 64 citations

Independence of the Effects of Epinephrine, Glucagon, and Adrenocorticotropin on Glucose Utilization from Those on Lipolysis in Isolated Rat Adipose Cells

1969 • 62 citations

Evidence for the involvement of cyclic-3′,5′-adenosine monophosphate in glucose utilization by isolated rat epididymal adipose cells

1967 • 62 citations

Adenosine 3',5'-monophosphate and protein kinase dependent phosphorylation of ribosomal protein

1973 • 61 citations

Adenosine 3′,5′-Monophosphate-dependent Protein Kinase from Bovine Anterior Pituitary Gland

1971 • 58 citations

Cyclic adenosine 3',5'-monophosphate dependent phosphorylation of ribosomal proteins from bovine anterior pituitary gland

1973 • 54 citations

Species differences in glucose metabolism and insulin responsiveness of adipose tissue

1966 • 46 citations

Divergent Biological Effects of Adenosine and Dibutyryl Adenosine 3′,5′-Monophosphate on the Isolated Fat Cell

1970 • 43 citations

The Plasma Membrane of Isolated Fat Cells

1973 • 42 citations

SDS-polyacrylamide gel electrophoresis of membrane proteins: Effect of phospholipids

1973 • 38 citations

Comparative Studies on the Physiology of Adipose Tissue1 1Investigations conducted in the authors' laboratory which are discussed in this review were supported by research grants AM 06056, AM 10715 and HE 05741 from the USPHS, and U-1820 and U-1562 from the Health Research Council of New York City.

1967 • 38 citations

The insulin-like activity of cyclic nucleotides and their inhibition by caffeine on the isolated fat cells

1970 • 35 citations

Phosphorylation of Muscle Membranes: Identification of a Membrane-Bound Protein Kinase

1973 • 33 citations

Effects of dibutyryl cyclic adenosine 3′,5′-monophosphate on glucose transport and metabolism in rat adipose tissue

1971 • 16 citations

Effects of Insulin on the Lipolytic System of Rat Fat Cells

1972 • 15 citations

DISTRIBUTION OF ADRENOCORTICOTROPHIC HORMONE-STIMULATED ADENYLATE CYCLASE IN THE ADRENAL CORTEX

1973 • 8 citations

Similar and opposite effects of dibutyryl cyclic AMP and insulin on glucose metabolism in adipose tissue

1973 • 7 citations