Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

1997 • 2,762 citations

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

Neuropathological Classification of Huntingtonʼs Disease

1985 • 2,517 citations

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

1997 • 2,184 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

Huntington Disease

1998 • 1,255 citations

Risk of Alzheimer's disease and duration of NSAID use

1997 • 1,113 citations

Differential loss of striatal projection neurons in Huntington disease.

1988 • 976 citations

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

1999 • 967 citations

Complement activation by beta-amyloid in Alzheimer disease.

1992 • 804 citations

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1995 • 736 citations

Evidence for Degenerative and Regenerative Changes in Neostriatal Spiny Neurons in Huntington's Disease

1985 • 614 citations

Activated Macrophages and Microglia Induce Dopaminergic Sprouting in the Injured Striatum and Express Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor

1999 • 569 citations

HISTOPATHOLOGIE DES NERVENSYSTEMS

1923 • 542 citations

Neuronal and Glial Somal Size in the Prefrontal Cortex

1998 • 530 citations

Morphometric Demonstration of Atrophic Changes in the Cerebral Cortex, White Matter, and Neostriatum in Huntington's Disease

1988 • 414 citations

Huntingtin interacts with a family of WW domain proteins

1998 • 386 citations

Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid Stimulation

1999 • 356 citations

Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins

1999 • 353 citations

Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNSIn Vivo

1998 • 353 citations

Thymosin β4 and Fx, an actin-sequestering peptide, are indistinguishable

1991 • 352 citations

Huntingtin localization in brains of normal and Huntington's disease patients

1997 • 338 citations

Increase in HLA-DR Immunoreactive Microglia in Frontal and Temporal Cortex of Chronic Schizophrenics

2000 • 332 citations

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

1987 • 267 citations

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging

1998 • 246 citations

Decreased Neuronal and Increased Oligodendroglial Densities in Huntington's Disease Caudate Nucleus

1991 • 225 citations

Morphometric analysis of the prefrontal cortex in Huntington's disease

1991 • 204 citations

Differential Macrophage Responses in the Peripheral and Central Nervous System during Wallerian Degeneration of Axons

1995 • 184 citations

Axonal Transport of N-terminal Huntingtin Suggests Early Pathology of Corticostriatal Projections in Huntington Disease

1999 • 169 citations

Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis

1995 • 159 citations

Thymosin beta 4 sequesters the majority of G-actin in resting human polymorphonuclear leukocytes.

1992 • 158 citations

Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells.

1992 • 153 citations

Aspartate residue 7 in amyloid β-protein is critical for classical complement pathway activation: Implications for Alzheimer's disease pathogenesis

1997 • 143 citations

Lesion of the rat entorhinal cortex leads to a rapid microglial reaction in the dentate gyrus

1991 • 142 citations

Neuronal Control of the Immune Response in the Central Nervous System

1998 • 122 citations

Thymosin β₄ Binds Actin in an Extended Conformation and Contacts both the Barbed and Pointed Ends

1997 • 111 citations

Evidence for neuronal degeneration and dendritic plasticity in cortical pyramidal neurons of Huntington's disease

1993 • 102 citations

Reactive microgIia in Creutzfeldt‐Jakob disease

1995 • 98 citations

Generation of Neuronal Intranuclear Inclusions by Polyglutamine-GFP: Analysis of Inclusion Clearance and Toxicity as a Function of Polyglutamine Length

1999 • 95 citations

The adrenoleukomyeloneuropathy complex

1981 • 90 citations

The cortical neuritic pathology of Huntington's disease

1995 • 89 citations

Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes.

1987 • 78 citations

Developmental expression of mRNAs encoding thymosins β4 and β10 in rat brain and other tissues

1990 • 78 citations

PATHOLOGIC CHANGES IN HUNTINGTON'S CHOREA

1927 • 72 citations

Microglial and Astrocytic Cell Responses in the Rat Hippocampus after an Intracerebroventricular Kainic Acid Injection

1993 • 68 citations

The CNS acute inflammatory response to excitotoxic neuronal cell death

1991 • 55 citations

Extensive and long‐lasting changes of glial cells following transection of the poscommissural fornix in the adult rat

1994 • 53 citations

Importance of Immunological and Inflammatory Processes in the Pathogenesis and THERAPY of Alzheimer's Disease

1998 • 52 citations

Expression of thymosin β4 messenger RNA in normal and kainate-treated rat forebrain

1999 • 43 citations

Microglial reaction in Pick's disease

1993 • 40 citations

Complement interactions with amyloid β1–42: A nidus for inflammation in AD brains

1997 • 39 citations

Inflammatory mechanisms and anti-inflammatory therapy in Alzheimer's disease

1996 • 35 citations

Mapping the binding site of thymosin β4 on actin by competition with G-actin binding proteins indicates negative co-operativity between binding sites located on opposite subdomains of actin

1997 • 25 citations

Localization of thymosin β4 to the neural tissues during the development of Xenopus laevis, as studied by in situ hybridization and immunohistochemistry

1994 • 20 citations

Change of phosphotyrosine immunoreactivity on microglia in the rat substantia nigra following striatal ischemic injury

1995 • 16 citations

Expression of thymosin β4 gene during Xenopus laevis embryogenesis

1992 • 13 citations

Neuroglia

1922 • 1 citations