Huntingtin interacts with a family of WW domain proteins

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

1993 • 3,080 citations

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

1997 • 2,762 citations

Neuropathological Classification of Huntingtonʼs Disease

1985 • 2,517 citations

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

1993 • 1,531 citations

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

1995 • 843 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1995 • 774 citations

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

1994 • 771 citations

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1995 • 736 citations

Inactivation of the Mouse Huntington's Disease Gene Homolog Hdh

1995 • 705 citations

The two-hybrid system: an assay for protein-protein interactions

1994 • 649 citations

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

1995 • 646 citations

A huntingtin-associated protein enriched in brain with implications for pathology

1995 • 597 citations

Huntingtons Disease

1986 • 551 citations

Correlation of Two-Hybrid Affinity Data with In Vitro Measurements

1995 • 536 citations

Widespread expression of Huntington's disease gene (IT15) protein product

1995 • 516 citations

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

1997 • 513 citations

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

1995 • 445 citations

Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide

1996 • 426 citations

Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.

1996 • 424 citations

Intranuclear Neuronal Inclusions: A Common Pathogenic Mechanism for Glutamine-Repeat Neurodegenerative Diseases?

1997 • 392 citations

Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product.

1994 • 390 citations

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

1997 • 384 citations

Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating Enzyme

1996 • 365 citations

HIP-I: A huntingtin interacting protein isolated by the yeast two-hybrid system

1997 • 335 citations

Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators.

1994 • 306 citations

The Regions of the Fe65 Protein Homologous to the Phosphotyrosine Interaction/Phosphotyrosine Binding Domain of Shc Bind the Intracellular Domain of the Alzheimer's Amyloid Precursor Protein

1995 • 295 citations

Structure and function of the WW domain

1996 • 290 citations

Symplekin, a novel type of tight junction plaque protein.

1996 • 286 citations

Interaction of Huntingtin-Associated Protein with Dynactin P150^Glued

1998 • 265 citations

The WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of DrosophilaEnabled

1997 • 243 citations

Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene.

1996 • 226 citations

Cloning of ligand targets: Systematic isolation of SH3 domain-containing proteins

1996 • 224 citations

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.

1996 • 213 citations

FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands

1997 • 208 citations

Characterization of the WW Domain of Human Yes-associated Protein and Its Polyproline-containing Ligands

1997 • 175 citations

Atrophin-1, the DRPLA Gene Product, Interacts with Two Families of WW Domain-Containing Proteins

1998 • 165 citations

Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).

1989 • 157 citations

Neurobiology of Huntington's Disease

1996 • 135 citations

Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain

1997 • 129 citations

SH3 Domain-dependent Association of Huntingtin with Epidermal Growth Factor Receptor Signaling Complexes

1997 • 112 citations

The WW module competes with the SH3 domain?

1996 • 112 citations

Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation

1996 • 112 citations

Identification of Prp40, a Novel Essential Yeast Splicing Factor Associated with the U1 Small Nuclear Ribonucleoprotein Particle

1996 • 99 citations

Huntington's disease: translating a CAG repeat into a pathogenic mechanism

1996 • 97 citations

Huntingtin interacts with cystathionine beta-synthase

1998 • 95 citations

Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae.

1995 • 94 citations

Differential Expression of Normal and Mutant Huntington's Disease Gene Alleles

1996 • 83 citations

Huntington's disease: CAG genetics expands neurobiology

1995 • 64 citations

The Genetic Defect Causing Huntington’s Disease: Repeated in Other Contexts?

1997 • 59 citations

Abnormal Gene Product Identified in Huntington′s Disease Lymphocytes and Brain

1995 • 43 citations

Studying Heterologous Transcription Factors in Yeast

1993 • 26 citations