An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

1988 • 2,903 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

2013 • 2,504 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.

1979 • 1,504 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters

1993 • 1,175 citations

Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria.

1982 • 1,152 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site

1983 • 667 citations

Guide to Yeast Genetics and Molecular Biology

1991 • 607 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

IMPORT OF PROTEINS INTO MITOCHONDRIA

1991 • 583 citations

Nucleotide sequence of an Escherichia coli chromosomal hemolysin

1985 • 572 citations

Two nuclear mutations that block mitochondrial protein import in yeast.

1984 • 490 citations

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.

1989 • 443 citations

PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.

1994 • 439 citations

A molecular model of MHC class-I-restricted antigen processing

1992 • 438 citations

Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism

1992 • 422 citations

RTG1 and RTG2: Two yeast genes required for a novel path of communication from mitochondria to the nucleus

1993 • 414 citations

Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter.

1992 • 410 citations

The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily.

1990 • 395 citations

Complete DNA sequence of yeast chromosome XI

1994 • 377 citations

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.

1992 • 352 citations

Homozygous Human TAP Peptide Transporter Mutation in HLA Class I Deficiency

1994 • 348 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Maternally transmitted histocompatibility antigen of mice: A hydrophobic peptide of a mitochondrially encoded protein

1990 • 324 citations

Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium

1982 • 322 citations

[13] Immunochemical identification of membrane proteins after sodium dodecyl sulfate—polyacrylamide gel electrophoresis

1983 • 309 citations

DNA sequence of the white locus of Drosophila melanogaster

1984 • 282 citations

Complete Nucleotide Sequence of Saccharomyces cerevisiae Chromosome VIII

1994 • 279 citations

Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria

1991 • 278 citations

The Simultaneous Symbiotic Origin of Mitochondria, Chloroplasts, and Microbodies

1987 • 274 citations

Molecular characterization of the oligopeptide permease of Salmonella typhimurium

1987 • 263 citations

Cloning of Two Novel ABC Transporters Mapping on Human Chromosome 9

1994 • 262 citations

Porin from Bacterial and Mitochondrial Outer Membrane

1985 • 246 citations

Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance.

1994 • 231 citations

Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene.

1977 • 231 citations

Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome

1992 • 228 citations

Determinants for glycophospholipid anchoring of the Saccharomyces cerevisiae GAS1 protein to the plasma membrane.

1991 • 222 citations

Phosphate-specific transport system of Escherichia coli: nucleotide sequence and gene-polypeptide relationships

1985 • 219 citations

Artificial mitochondrial presequences.

1986 • 203 citations

Guide to molecular cloning techniques

1988 • 198 citations

Gene SNQ2 of Saccharomyces cerevislae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases

1993 • 198 citations

Bacterial cytochromes c biogenesis.

1992 • 179 citations

Communication Between Mitochondria and the Nucleus in Regulation of Cytochrome Genes in the Yeast Saccharomyces cerevisiae

1989 • 178 citations

Bacterial periplasmic permeases belong to a family of transport proteins operating fromEscherichia colito human: Traffic ATPases

1990 • 174 citations

MPI1, an essential gene encoding a mitochondrial membrane protein, is possibly involved in protein import into yeast mitochondria.

1992 • 173 citations

The Mitochondrial Targeting function of Randomly Generated Peptide Sequences Correlates with Predicted Helical Amphiphilicity

1989 • 164 citations

Discovery and sequence analysis of bacterial genes involved in the biogenesis of c-type cytochromes.

1991 • 163 citations

The carboxyl-terminal two-thirds of the ADP/ATP carrier polypeptide contains sufficient information to direct translocation into mitochondria.

1987 • 160 citations

Import of proteins into mitochondria: a 70 kilodalton outer membrane protein with a large carboxy-terminal deletion is still transported to the outer membrane.

1983 • 160 citations

Sequence of themalKgene inE.coliK12

1982 • 157 citations

Signals guiding proteins to their correct locations in mitochondria

1987 • 145 citations

Sequences of Escherichia coli uvrA gene and protein reveal two potential ATP binding sites.

1986 • 137 citations

Identification of a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane.

1992 • 123 citations

Citrate synthase encoded by the CIT2 gene of Saccharomyces cerevisiae is peroxisomal.

1990 • 120 citations

The cleavable presequence is not essential for import and assembly of the phosphate carrier of mammalian mitochondria but enhances the specificity and efficiency of import.

1992 • 88 citations

Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal.

1990 • 87 citations

Sequence analysis of the translational elongation factor 3 from Saccharomyces cerevisiae.

1990 • 86 citations

Protein import into yeast mitochondria: the inner membrane import site protein ISP45 is the MPI1 gene product.

1993 • 83 citations

Determinants for Glycophospholipid Anchoring of the Saccharomyces cerevisiae GAS1 Protein to the Plasma Membrane

1991 • 74 citations

Mitochondrial import of the ADP/ATP carrier protein in Saccharomyces cerevisiae. Sequences required for receptor binding and membrane translocation.

1988 • 73 citations

Porphyrin mutants of : Correlated lesions in sterol and fatty acid biosynthesis

1974 • 73 citations

<scp>XII</scp><scp>XVI</scp>. Yeast sequencing reports. Mapping and sequencing of two yeast genes belonging to the ATP‐binding cassette superfamily

1994 • 69 citations

Chapter 20 Protein Import into Isolated Yeast Mitochondria

1991 • 53 citations

Protein translocation across mitochondrial membranes

1992 • 43 citations

The product of the YCR105 gene located on the chromosome III from Saccharomyces cerevisiae presents homologies to ATP‐dependent permeases

1991 • 39 citations

Citrate Synthase Encoded by the CIT2 Gene of Saccharomyces cerevisiae Is Peroxisomal

1990 • 35 citations

Isolation and characterization of the structural gene encoding elongation factor 3

1990 • 24 citations

Dedicated Transporters for Peptide Export and Intercompartmental Traffic in the Yeast Saccharomyces cerevisiae

1992 • 22 citations