Vulnerability of the Neuronal Cytoskeleton in Aging and Alzheimer Disease: Widespread Involvement of All Three Major Filament Systems

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

LABORATORY INVESTIGATION

1956 • 1,491 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Uber eine eigenartige Erkrankung der Hirnrinde

1907 • 1,332 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants

1982 • 541 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Presence of both odor identification and detection deficits in alzheimer's disease

1987 • 477 citations

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

1986 • 419 citations

Identification of the major multiphosphorylation site in mammalian neurofilaments.

1988 • 394 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

Aberrant neurofilament phosphorylation in Alzheimer disease.

1985 • 339 citations

Archives of pathology & laboratory medicine

2016 • 337 citations

A Textbook of Neuropathology

1950 • 325 citations

THE SIGNIFICANCE OF THE LEWY BODY IN THE DIAGNOSIS OF IDIOPATHIC PARKINSON'S DISEASE

1989 • 310 citations

Pathological changes in olfactory neurons in patients with Alzheimer's disease

1989 • 310 citations

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

1988 • 308 citations

Senile Dementia of the Alzheimer Type Without Neocortical Neurofibrillary Tangles

1987 • 269 citations

Biochemistry of Altered Brain Proteins in Alzheimer's Disease

1989 • 261 citations

Lewy Bodies of Parkinson's Disease Contain Neurofilament Antigens

1983 • 256 citations

Alz-50, Ubiquitin and Tau Immunoreactivity of Neurofibrillary Tangles, Pick Bodies and Lewy Bodies

1988 • 238 citations

Paired helical filaments from Alzheimer disease patients contain cytoskeletal components.

1985 • 220 citations

Textbook of neuropathology

1986 • 215 citations

Diffuse Lewy body disease

1987 • 203 citations

Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein.

1987 • 200 citations

Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques

1989 • 199 citations

Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.

1989 • 184 citations

Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles.

1987 • 181 citations

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

1990 • 154 citations

Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2.

1987 • 147 citations

Neuropil Threads Occur in Dendrites of Tangle—Bearing Nerve Cells

1988 • 147 citations

Hirano Body Filaments Contain Actin and Actin-Associated Proteins

1987 • 140 citations

An Antigenic Profile of Lewy Bodies: Immunocytochemical Indication for Protein Phosphorylation and Ubiquitination

1989 • 138 citations

The olfactory and cognitive deficits of parkinson's disease: Evidence for independence

1989 • 136 citations

Alzheimer's paired helical filaments share epitopes with neurofilament side arms.

1986 • 132 citations

Senile dementia of Alzheimer type: Astroglial reaction to extracellular neurofibrillary tangles in the hippocampus

1982 • 126 citations

Dementia

1989 • 125 citations

Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins.

1988 • 125 citations

Lewy Bodies Contain Epitopes Both Shared and Distinct from Alzheimer Neurofibrillary Tangles

1988 • 124 citations

The Association of Actin with Hirano Bodies

1983 • 112 citations

Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum

1982 • 97 citations

Hirano bodies contain tau protein

1987 • 95 citations

Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads.

1991 • 82 citations

The neurobiology of Alzheimer's disease

1989 • 67 citations

Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer's disease hippocampus.

1989 • 67 citations

Immunohistochemical localization of neurofilament protein in neuronal degenerations

1984 • 66 citations

Immunocytochemical properties of Alzheimer straight filaments

1987 • 65 citations

Intraneuronal and extracellular neurofibrillary tangles exhibit mutually exclusive cytoskeletal antigens

1988 • 63 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (?)

1987 • 63 citations

Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles.

1990 • 60 citations

Antibodies to neurofibrillary tangles of Alzheimer's disease raised from human and animal neurofilament fractions.

1983 • 57 citations

The presence of tau distinguishes Lewy bodies of diffuse Lewy body disease from those of idiopathic Parkinson disease

1989 • 56 citations

Lewy bodies of Parkinson's disease. Immune electron microscopic demonstration of neurofilament antigens in constituent filaments.

1986 • 52 citations

Isolation and chemical characterization of Alzheimer's disease paired helical filament cytoskeletons: differentiation from amyloid plaque core protein.

1988 • 45 citations

Properties of antigenic determinants that distinguish neurofibrillary tangles in progressive supranuclear palsy and Alzheimer's disease.

1988 • 45 citations

Cellular and molecular biology of alzheimer's disease

1989 • 25 citations

Alterations in neuronal cytoskeleton in Alzheimer disease

1990 • 15 citations

Monoclonal Antibodies Show Cross-Reactivity of Alzheimer Neurofibrillary Tangles and Heat-Stable Microtubule-Associated Proteins

1987 • 5 citations

Cytoskeletal Abnormalities in Parkinson’s Disease

1987 • 5 citations

Microfilament Involvement in Hirano Body Formation

1987 • 3 citations