The effect of nicotine on developing brain catecholamine systems

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1964 • 5,110 citations

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

1993 • 1,455 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

1996 • 1,083 citations

Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat

1989 • 1,049 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin

1985 • 1,037 citations

Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons

1995 • 1,017 citations

Hippocampal synaptic transmission enhanced by low concentrations of nicotine

1996 • 955 citations

Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat.

1993 • 914 citations

α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

1994 • 869 citations

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

1992 • 858 citations

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

1992 • 827 citations

Nicotine activates and desensitizes midbrain dopamine neurons

1997 • 762 citations

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats

1986 • 693 citations

Late prenatal ontogeny of central monoamine neurons in the rat: Fluorescence histochemical observations

1973 • 651 citations

Nicotine maintains robust self-administration in rats on a limited-access schedule

1989 • 586 citations

Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors

1991 • 552 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.

1993 • 543 citations

Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons

1985 • 527 citations

Neurotransmitters in the regulation of neuronal cytoarchitecture

1988 • 525 citations

The pre- and postnatal development of the dopaminergic cell groups in the ventral mesencephalon and the dopaminergic innervation of the striatum of the rat

1988 • 499 citations

Light‐microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. II. Late ontogeny

1981 • 497 citations

Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens

1973 • 477 citations

Smoking in Pregnancy and Subsequent Child Development

1973 • 451 citations

Extent of Nicotine and Cotinine Transfer to the Human Fetus, Placenta and Amniotic Fluid of Smoking Mothers

1985 • 426 citations

Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat.

1978 • 421 citations

Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat

1975 • 411 citations

Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes.

1997 • 387 citations

Developmental Regulation of Nicotinic Acetylcholine Receptors

1987 • 354 citations

Characterization of Nicotinic Receptor‐Mediated [³H]Dopamine Release from Synaptosomes Prepared from Mouse Striatum

1992 • 352 citations

Maternal Smoking During Pregnancy and Psychopathology in Offspring Followed to Adulthood

1999 • 350 citations

Efferent projections of nucleus locus coeruleus: Topographic organization of cells of origin demonstrated by three-dimensional reconstruction

1986 • 345 citations

Persistent Behavior at High Rates Maintained by Intravenous Self-Administration of Nicotine

1981 • 341 citations

Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems

1995 • 338 citations

A functional effect of dopamine in the nucleus accumbens and in some other dopamine-rich parts of the rat brain

1975 • 323 citations

Brain nicotinic receptors: structure and regulation, role in learning and reinforcement

1998 • 314 citations

Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats.

1988 • 313 citations

Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes

1993 • 303 citations

Decreased Muscarinic Receptor Binding in the Arcuate Nucleus in Sudden Infant Death Syndrome

1995 • 301 citations

Nicotinic excitation of rat ventral tegmental neurones in vitro studied by intracellular recording

1989 • 291 citations

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine‐Treated Rats

1997 • 288 citations

Selective dopamine antagonists reduce nicotine self-administration

1991 • 279 citations

Prenatal adverse effects of nicotine on the developing brain

1988 • 271 citations

Release of [³H]‐noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [³H]‐dopamine release

1996 • 263 citations

Diversity of neuronal nicotinic acetylcholine receptors: Lessons from behavior and implications for cns therapeutics

1995 • 258 citations

Neuronal nicotinic receptors: Molecular organization and regulations

1995 • 254 citations

The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (α5) in the rat central nervous system

1990 • 254 citations

Regulation of dopamine release by presynaptic nicotinic receptors in rat striatal slices: Effect of nicotine in a low concentration

1979 • 250 citations

Nicotine administration to rats: Methodological considerations

1987 • 239 citations

Stimulation of nigrostriatal dopamine neurones by nicotine

1982 • 232 citations

β3: A New Member of Nicotinic Acetylcholine Receptor Gene Family Is Expressed in Brain

1989 • 229 citations

New frontiers in basal ganglia research

1990 • 223 citations

Immunocytochemical localization of a neuronal nicotinic receptor: the beta 2-subunit

1993 • 222 citations

Hyperactivity and hypoactivity produced by lesions to the mesolimbic dopamine system

1981 • 216 citations

N-methyl-d-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens

1997 • 211 citations

Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties.

1994 • 207 citations

The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain

1992 • 205 citations

Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H]acetylcholine to nicotinic receptors

1985 • 205 citations

Enduring Changes in Dopamine Receptor Cells of Pups from Drug Administration to Pregnant and Nursing Rats

1979 • 203 citations

Nicotinic Modulation of [³H]Dopamine Release from Striatal Synaptosomes: Pharmacological Characterisation

1990 • 198 citations

Gene transcripts for the nicotinic acetylcholine receptor subunit, beta4, are distributed in multiple areas of the rat central nervous system

1992 • 195 citations

Effect of nicotine on extracellular levels of neurotransmitters assessed by microdialysis in various brain regions: Role of glutamic acid

1992 • 193 citations

Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system

1991 • 193 citations

Behavioral consequences of abnormal cortical development: insights into developmental disabilities

1997 • 192 citations

Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: Implications for sudden infant death syndrome

1995 • 188 citations

Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens

1989 • 174 citations

Actions of acetylcholine and nicotine on rat locus coeruleus neurons in vitro

1986 • 169 citations

Pattern formation in the striatum: developmental changes in the distribution of striatonigral neurons

1987 • 161 citations

Condition-independent sensitization of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat

1996 • 157 citations

Cigarette smokers self-administer intravenous nicotine

1983 • 157 citations

Stimulation of [³H]Dopamine Release by Nicotine in Rat Nucleus Accumbens

1987 • 154 citations

Development of the catecholamine neurons in human embryos and fetuses, with special emphasis on the innervaton of the cerebral cortex

1995 • 145 citations

SMOKING DURING PREGNANCY AND ITS EFFECTS ON THE FETUS

1972 • 143 citations

Prenatal exposure to nicotine via maternal infusions: effects on development of catecholamine systems.

1988 • 142 citations

Prenatal nicotine effects on memory in rats: pharmacological and behavioral challenges

1996 • 138 citations

Response of the hypothalamo-pituitary-adrenal axis to nicotine

1998 • 136 citations

Neuronal nicotinic acetylcholine receptor β‐subunit is coded for by the cDNA clone α₄

1987 • 134 citations

Prenatal nicotine exposure affects the development of the central serotonergic system as well as the dopaminergic system in rat offspring: involvement of route of drug administrations

1997 • 132 citations

Codistribution of nicotinic acetylcholine receptor subunit ?3 and ?4 mRNAs during rat brain development

1997 • 131 citations

Developmental expression ofα7 neuronal nicotinic receptor messenger RNA in rat sensory cortex and thalamus

1995 • 130 citations

Lateralization and functional organization of the locus coeruleus projection to the trigeminal somatosensory pathway in rat

1997 • 129 citations

Prenatal development of the biogenic amine systems of the mouse brain

1973 • 128 citations

Pharmacological characterization of neuronal acetylcholine gated ion channel receptor-mediated hippocampal norepinephrine and striatal dopamine release from rat brain slices.

1995 • 126 citations

Prenatal Nicotine Exposure Modifies Behavior of Mice Through Early Development

1998 • 124 citations

Effects of prenatal nicotine exposure on neuronal development: Selective actions on central and peripheral catecholaminergic pathways

1987 • 124 citations

Effects of acute and chronic prenatal nicotine treatment on central catecholamine systems of male and female rat fetuses and offspring.

1989 • 121 citations

Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists

1994 • 120 citations

Nicotine and Cotinine Concentrations in the Nursing Mother and Her Infant

1990 • 118 citations

Nicotinic receptor function determined by stimulation of rubidium efflux from mouse brain synaptosomes.

1993 • 112 citations

Pre- and postnatal development of high-affinity [3H]nicotine binding sites in rat brain regions: an autoradiographic study

1992 • 111 citations

Tyrosine hydroxylase and serotonin containing cells in embryonic rat rhombencephalon: A whole‐mount immunocytochemical study

1988 • 110 citations

Functional and developmental studies of the peripheral arterial chemoreceptors in rat: effects of nicotine and possible relation to sudden infant death syndrome.

1995 • 105 citations

The Consequences of Prenatal Substance Use for the Developing Fetus, Newborn, and Young Child

1993 • 105 citations

Nicotine Exposure During a Critical Period of Development Leads to Persistent Changes in Nicotinic Acetylcholine Receptors of Adult Rat Brain

1998 • 102 citations

Nicotine and morphine differentially activate brain dopamine in prefrontocortical and subcortical terminal fields: effects of acute and repeated injections.

1992 • 101 citations

Alterations in hippocampal cholinergic receptors and hippocampal behaviors after early exposure to nicotine

1992 • 101 citations

Effects of maternal nicotine injections on brain development in the rat: Ornithine decarboxylase activity, nucleic acids and proteins in discrete brain regions

1986 • 100 citations

Maternal nicotine depresses eupneic ventilation of neonatal rats

1999 • 100 citations

The effects of prenatal nicotine on radial-arm maze performance in rats

1991 • 99 citations

Effect of maternal nicotine on the development of sites for [³H]nicotine binding in the fetal brain

1985 • 98 citations

Perinatal nicotine exposure impairs ability of newborn rats to autoresuscitate from apnea during hypoxia

1998 • 97 citations

Nicotine-induced release of noradrenaline from hypothalamic synaptosomes

1980 • 96 citations

Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions

1992 • 95 citations

Development and plasticity of the locus coeruleus: A review of recent physiological and pharmacological experimentation

1990 • 95 citations

Nicotine-induced release of catecholamines from rat hippocampus and striatum

1978 • 93 citations

Effects of prenatal nicotine exposure on rat striatal dopaminergic and nicotinic systems

1989 • 93 citations

Effect of acute administration of nicotine on in vivo release of noradrenaline in the hippocampus of freely moving rats: A dose-response and antagonist study

1991 • 91 citations

Chronic Nicotine Administration Differentially Affects Neurotransmitter Release from Rat Striatal Slices

1994 • 91 citations

Neonatal nicotine exposure induces permanent changes in brain nicotinic receptors and behaviour in adult mice

1991 • 91 citations

Regional variation in the effects of nicotine on catecholamine overflow in rat brain

1997 • 90 citations

Control of behavior by intravenous nicotine injections in laboratory animals

1983 • 90 citations

Sex differences in nicotine's effects on consummatory behavior and body weight in rats

1987 • 89 citations

Reinforcing effects of nicotine in humans and experimental animals responding under intermittent schedules of IV drug injection

1988 • 88 citations

Hyperactivity Induced by Prenatal Nicotine Exposure Is Associated with an Increase in Cortical Nicotinic Receptors

1997 • 88 citations

Nicotine-induced norepinephrine release in the rat amygdala and hippocampus is mediated through brainstem nicotinic cholinergic receptors.

1998 • 88 citations

Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D1 receptor and is dependent on NMDA stimulation

1994 • 84 citations

THE INTERRELATIONSHIP OF MATERNAL SMOKING AND INCREASED PERINATAL MORTALITY WITH OTHER RISK FACTORS. FURTHER ANALYSIS OF THE ONTARIO PERINATAL MORTALITY STUDY, 1960–1961

1974 • 83 citations

Neuronal bungarotoxin blocks the nicotinic stimulation of endogenous dopamine release from rat striatum

1989 • 82 citations

Role of the locus coeruleus in the noradrenergic response to a systemic administration of nicotine

1993 • 82 citations

Localization of nicotinic cholinergic receptors in rat brain: Autoradiographic studies with [3H]cytisine

1994 • 82 citations

Early evidence of catecholaminergic cell groups in 5- and 6-week-old human embryos using tyrosine hydroxylase and dopamine-β-hydroxylase immunocytochemistry

1991 • 80 citations

Chapter 7: Nicotinic receptors in mammalian brain: localization and relation to cholinergic innervation

1993 • 80 citations

Ontogeny of μ-, δ- and κ-opioid receptors mediating inhibition of neurotransmitter release and adenylate cyclase activity in rat brain

1990 • 79 citations

MK801 attenuates behavioural adaptation to chronic nicotine administration in rats

1992 • 72 citations

Nicotine Attenuates the Ventilatory Response to Hypoxia in the Developing Lamb

1995 • 69 citations

Characterization of Nicotine‐Induced Desensitization of Evoked Dopamine Release from Rat Striatal Synaptosomes

1994 • 68 citations

Maternal substance use and subsequent Sudden Infant Death Syndrome (SIDS) in offspring

1991 • 67 citations

Effect of nicotine on single cell activity in the noradrenergic nucleus locus coeruleus.

1980 • 67 citations

Nicotine-induced sensitization to ambulatory stimulant effect produced by daily administration into the ventral tegmental area and the nucleus accumbens in rats

1992 • 67 citations

Differential expression of the neuronal acetylcholine receptor α2 subunit gene during chick brain development

1990 • 64 citations

Locomotion induced by ventral tegmental microinjections of a nicotinic agonist

1990 • 64 citations

Nanomolar concentrations of nicotine increase the release of [3H]dopamine from rat striatal synaptosomes

1995 • 63 citations

Increases in tyrosine hydroxylase messenger RNA in the locus coeruleus after a single dose of nicotine are followed by time-dependent increases in enzyme activity and noradrenaline release

1993 • 61 citations

Prenatal Nicotine Sex-Dependently Alters Agonist-Induced Locomotion and Stereotypy

1997 • 61 citations

Deficits in spatial-memory tasks following lesions of septal dopaminergic terminals in the rat

1986 • 60 citations

Effects of nicotine on brain stem mechanisms of cardiovascular control.

1993 • 60 citations

Nicotine treatment counteracts perinatal asphyxia-induced changes in the mesostriatal/limbic dopamine systems and in motor behaviour in the four-week-old male rat

1995 • 59 citations

Effects of environmental conditioning on the development of nicotine sensitization: behavioral and neurochemical analysis

1996 • 58 citations

Effects of prenatal administration of nicotine on amino acid pools, protein metabolism, and nicotine binding in the brain

1982 • 56 citations

Nicotine-induced cFos expression in the hypothalamic paraventricular nucleus is dependent on brainstem effects: correlations with cFos in catecholaminergic and noncatecholaminergic neurons in the nucleus tractus solitarius.

1996 • 56 citations

Maternal passive smoking during pregnancy and fetal developmental toxicity. Part 1: gross morphological effects

1999 • 55 citations

Adolescent Substance Use: Epidemiology and Implications for Public Policy 241

1995 • 54 citations

Peripheral induction of burst firing in locus coeruleus neurons by nicotine mediated via excitatory amino acids

1989 • 53 citations

Nicotine‐Stimulated Release of [³H]Norepinephrine from Fetal Rat Locus Coeruleus Cells in Culture

1998 • 52 citations

The effects of nicotine administration in utero upon activity in the rat

1970 • 51 citations

First Trimester Development of the Human Nigrostriatal Dopamine System

1996 • 46 citations

Postnatal behavioural effects of maternal nicotine exposure in rats

1988 • 44 citations

Perinatal administration of nicotine alters subsequent sexual behavior and testosterone levels of male rats

1989 • 44 citations

Neurotransmitters as Neurotrophic Factors

1993 • 40 citations

Prenatal Exposure to Nicotine: Effects on Prepulse Inhibition and Central Nicotinic Receptors

1997 • 40 citations

Prenatal haloperidol alters striatal dopamine and opiate receptors

1984 • 39 citations

Postnatal development of two nicotinic cholinergic receptors in seven mouse brain regions

1990 • 38 citations

Abuse of alcohol, drugs and tobacco during pregnancy--consequences for the child.

1979 • 37 citations

Nicotinic Agonists Administered into the Fourth Ventricle Stimulate Norepinephrine Secretion in the Hypothalamic Paraventricular Nucleus: An in vivo Microdialysis Study

1995 • 37 citations

Nicotine- or epinephrine-induced uteroplacental vasoconstriction and fetal growth in the rat

1994 • 36 citations

Chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats

1993 • 36 citations

Developmental regulation of multiple nicotinic AChR channel subtypes in embryonic chick habenula neurons: contributions of both theα2 andα4 subunit genes

1994 • 36 citations

Chapter 17 Regulation by nicotine of midbrain dopamine neurons

1989 • 35 citations

N-type calcium channels are involved in the dopamine releasing effect of nicotine

1992 • 33 citations

A new device for monitoring early motor development: Prenatal nicotine-induced changes

1988 • 32 citations

Chronic prenatal nicotine exposure sensitizes rat brain to acute postnatal nicotine challenge as assessed with ornithine decarboxylase

1991 • 31 citations

Effects of nicotine on dopaminergic nigrostriatal axons requires stimulation of presynaptic glutamatergic receptors.

1996 • 30 citations

Chapter 9 Nicotinic acetylcholine receptors on hippocampal neurons: cell compartment-specific expression and modulatory control of channel activity

1996 • 27 citations

In search of a mechanism for receptor-mediated neurobehavioral teratogenesis by nicotine: catecholamine release by nicotine in immature rat brain regions

1994 • 26 citations

Dopaminergic neuron development in rats: Biochemical study from prenatal life to adulthood

1992 • 25 citations

Biochemical changes, early brain growth suppression and impaired detour learning in nicotine-treated chicks

1994 • 23 citations

Tyrosine administration to pregnant rats induces persistent behavioral modifications in the male offspring

1987 • 21 citations

Catecholamine mechanisms in medio-basal hypothalamus influence prolactin but not growth hormone secretion

1982 • 20 citations

Adrenoceptors in the preoptic-anterior hypothalamic area stimulate secretion of prolactin but not growth hormone in the male rat

1986 • 18 citations

Trends in Teenage Smoking During Pregnancy

1990 • 16 citations

Exposure to threshold doses of nicotine in utero: II. Neuroendocrine response to nicotine in adult male offspring

1994 • 10 citations

Spontaneous and Drug-Induced Locomotor Activity after Partial Dopamine Denervation of the Ventral Striatum

1986 • 9 citations

Catecholamines and Nicotine in Early Neuroendocrine Organization1

2015 • 6 citations

Deleted Work

1955 • 0 citations